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035 a| (Sirsi) o648769791;

035 a| (OCoLC)648769791;

040 a| EREc| EREd| EREd| UtOrBLW;

049 a| EREE;

090 a| QP86;

100 1 a| Finch, Adria D.?| UNAUTHORIZED;

245 10 a| Neural mechanisms contribute to the age related increase in metabolic cost of gait /c| Adria D. Finch.;

260 a| [Greenville, N.C.] :b| East Carolina University,c| 2010.;

300 a| 99 pages :b| illustrations (color), digital, PDF file;

336 a| text2| rdacontent;

337 a| computer2| rdamedia;

338 a| online resource2| rdacarrier;

500 a| Presented to the faculty of the Department of Exercise and Sport Science.;

500 a| Advisor: Tibor Hortobagyi.;

500 a| Title from PDF t.p. (viewed Sep. 1, 2010).;

502 b| M.S.c| East Carolina Universityd| 2010.;

504 a| Includes bibliographical references.;

520 3 a| Aging is associated with biomechanical and physiological changes in several organ systems, including neural changes of voluntary movement. One manifestation of age-related changes in neural control of gait is the increased activation of muscles that are antagonist to the prim movers during the stance phase of gait. Another age-related adaptation is the increased metabolic cost of locomotion. Several studies have attempted to link gait mechanics to the increased cost of transport, but none of the mechanical gait variables accounted for the age-related increase in oxygen uptake. Here we hypothesized that the related increase in metabolic cost during gait is mediated by increased antagonist muscle coactivation. EMG and oxygen consumption data were collected during treadmill walking to determine the levels of antagonist muscle coactivation and metabolic cost. The data revealed that old subjects experienced significantly greater levels of both coactivation and metabolic cost. Old subjects had 4-17% greater levels of metabolic cost of gait than young subjects, and 53-61% greater levels of total antagonist muscle coactivation than young subjects. Regression analyses showed that there was a strong association between the level of antagonist muscle coactivation and metabolic cost of gait, suggesting that neural factors contribute to the age-related metabolic adaptations in gait.;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

650 0 a| Aging.=| ^A70;

650 0 a| Gait in humans.=| ^A231004;

650 0 a| Adaptation (Physiology)=| ^A931;

650 0 a| Biomechanics.=| ^A1125;

650 0 a| Gerontology.=| ^A2920;

653 a| Biomechanics;

653 a| Gerontology;

700 1 a| Hortobágyi, Tibor.=| ^A1026447;

710 2 a| East Carolina University.b| Department of Exercise and Sport Science.?| UNAUTHORIZED;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/2714;

949 o| jgml;

994 a| C0b| ERE;

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998 a| 2284733;

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999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 2284733-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 7/19/2010x| ETDz| HERESOURCE;

Neural mechanisms contribute to the age related increase in metabolic cost of gait / Adria D. Finch.

Author/creator	Finch, Adria D.
Other author	Hortobágyi, Tibor.
Other author	East Carolina University. Department of Exercise and Sport Science.
Format	Theses and dissertations
Publication Info	[Greenville, N.C.] : East Carolina University, 2010.
Description	99 pages : illustrations (color), digital, PDF file
Supplemental Content	Access via ScholarShip
Subjects	Aging. Gait in humans. Adaptation (Physiology) Biomechanics. Gerontology.

Summary	Aging is associated with biomechanical and physiological changes in several organ systems, including neural changes of voluntary movement. One manifestation of age-related changes in neural control of gait is the increased activation of muscles that are antagonist to the prim movers during the stance phase of gait. Another age-related adaptation is the increased metabolic cost of locomotion. Several studies have attempted to link gait mechanics to the increased cost of transport, but none of the mechanical gait variables accounted for the age-related increase in oxygen uptake. Here we hypothesized that the related increase in metabolic cost during gait is mediated by increased antagonist muscle coactivation. EMG and oxygen consumption data were collected during treadmill walking to determine the levels of antagonist muscle coactivation and metabolic cost. The data revealed that old subjects experienced significantly greater levels of both coactivation and metabolic cost. Old subjects had 4-17% greater levels of metabolic cost of gait than young subjects, and 53-61% greater levels of total antagonist muscle coactivation than young subjects. Regression analyses showed that there was a strong association between the level of antagonist muscle coactivation and metabolic cost of gait, suggesting that neural factors contribute to the age-related metabolic adaptations in gait.
General note	Presented to the faculty of the Department of Exercise and Sport Science.
General note	Advisor: Tibor Hortobagyi.
General note	Title from PDF t.p. (viewed Sep. 1, 2010).
Dissertation note	M.S. East Carolina University 2010.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

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Neural mechanisms contribute to the age related increase in metabolic cost of gait / Adria D. Finch.

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