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049 a| EREE;

050 4 a| QP752.F35b| B37 2004;

100 1 a| Basilio, Jessica L.,e| author.?| UNAUTHORIZED;

245 14 a| The effects of 10 days of endurance exercise training on skeletal muscle fatty acid oxidation in lean African-American and Caucasian women /c| by Jessica L. Basilio.;

264 0 c| 2004.;

300 a| 100 leaves :b| illustrations, forms ;c| 28 cm;

336 a| textb| txt2| rdacontent;

337 a| unmediatedb| n2| rdamedia;

338 a| volumeb| nc2| rdacarrier;

502 b| M.A.c| East Carolina Universityd| 2004;

500 a| Presented to the faculty of the School of Health and Human Performance.;

500 a| Advisor: Ronald N. Cortright;

520 3 a| BACKGROUND: The incidence of obesity and diabetes is greater among African-American (AAW) vs. Caucasian women (CW). Recent data demonstrate that skeletal muscle defects may exist in the ability of pre-obese AAW to oxidize fatty acids. predisposing them to obesity and diabetes. In lean CW, endurance exercise training (EET) increases the oxidative capacity of skeletal muscle, but its effects are unknown in lean AAW. PURPOSE: To determine the effects of EET on skeletal muscle fatty acid oxidation in lean AAW and CW. HYPOTHESIS: Ten days of EET will improve skeletal muscle fatty acid oxidation in lean AAW and CW. METHODS: Seven sedentary, lean CW (BMI = 23.6 ± 0.74 kg/m², % Fat = 24.0 ± 0.81, age = 27.9 ± 2.54 y; mean ± SEM) and six sedentary, lean AAW (BMI = 21.9 ± 0.91, % Fat = 19.7 ± 1.58, age = 25.2 ± 1.4) participated. Subjects exercised on a stationary cycle ergometer for ten consecutive days at 75% of their V02peak for sixty minutes. Fatty acid oxidation was measured as captured ¹⁴C02 in whole muscle homogenates from muscle biopsies ofthe vastus lateralis using 1-¹⁴C palmitate. RESULTS: Rates of skeletal muscle palmitate oxidation increased similarly (P = .05) in lean AAW (37.4 ± 9.3 to 58.2 ± 14.7 nmol/g protein/min) vs. lean CW (52.5 + 10.4 to 74.0 ± 10.7, nmol/g protein/min) in response to ten days of EET. CONCLUSION: Ten days of EET increases the capacity of skeletal muscle to oxidize fatty acids similarly in AAW vs. CW. These data suggest the use of EET as an effective treatment against obesity in AAW. Supported in part by NIH DK56112 and NIH 1 R21 DK065183;

504 a| Includes bibliographical references (leaves 61-65).;

650 0 a| Fatty acidsx| Synthesis.=| ^A708989;

650 0 a| Exercise for women.=| ^A501;

650 0 a| Obesity in women.=| ^A466827;

650 0 a| African American womenx| Physiology.=| ^A23816;

650 0 a| Women, Whitex| Physiology.=| ^A524111;

650 7 a| Exercise for women.2| fast0| (OCoLC)fst00918045;

650 7 a| Fatty acidsx| Synthesis.2| fast0| (OCoLC)fst00921969;

650 7 a| Obesity in women.2| fast0| (OCoLC)fst01042775;

655 7 a| Academic theses.2| fast0| (OCoLC)fst01726453;

655 7 a| Academic theses.2| lcgft;

655 7 a| Thèses et écrits académiques.2| rvmgf0| (CaQQLa)RVMGF-000001173;

655 2 a| Academic Dissertation.0| (DNLM)D019478?| UNAUTHORIZED;

700 1 a| Cortright, Ronald N.,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| School of Health and Human Performance.?| UNAUTHORIZED;

856 41 z| Access via ScholarShipu| http://hdl.handle.net/10342/10194;

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The effects of 10 days of endurance exercise training on skeletal muscle fatty acid oxidation in lean African-American and Caucasian women / by Jessica L. Basilio.

Author/creator	Basilio, Jessica L. author.
Other author	Cortright, Ronald N., degree supervisor.
Other author	East Carolina University. School of Health and Human Performance.
Format	Theses and dissertations
Production	2004.
Description	100 leaves : illustrations, forms ; 28 cm
Supplemental Content	Access via ScholarShip
Subjects	Fatty acids--Synthesis. Exercise for women. Obesity in women. African American women--Physiology. Women, White--Physiology.

Summary	BACKGROUND: The incidence of obesity and diabetes is greater among African-American (AAW) vs. Caucasian women (CW). Recent data demonstrate that skeletal muscle defects may exist in the ability of pre-obese AAW to oxidize fatty acids. predisposing them to obesity and diabetes. In lean CW, endurance exercise training (EET) increases the oxidative capacity of skeletal muscle, but its effects are unknown in lean AAW. PURPOSE: To determine the effects of EET on skeletal muscle fatty acid oxidation in lean AAW and CW. HYPOTHESIS: Ten days of EET will improve skeletal muscle fatty acid oxidation in lean AAW and CW. METHODS: Seven sedentary, lean CW (BMI = 23.6 ± 0.74 kg/m², % Fat = 24.0 ± 0.81, age = 27.9 ± 2.54 y; mean ± SEM) and six sedentary, lean AAW (BMI = 21.9 ± 0.91, % Fat = 19.7 ± 1.58, age = 25.2 ± 1.4) participated. Subjects exercised on a stationary cycle ergometer for ten consecutive days at 75% of their V02peak for sixty minutes. Fatty acid oxidation was measured as captured ¹⁴C02 in whole muscle homogenates from muscle biopsies ofthe vastus lateralis using 1-¹⁴C palmitate. RESULTS: Rates of skeletal muscle palmitate oxidation increased similarly (P = .05) in lean AAW (37.4 ± 9.3 to 58.2 ± 14.7 nmol/g protein/min) vs. lean CW (52.5 + 10.4 to 74.0 ± 10.7, nmol/g protein/min) in response to ten days of EET. CONCLUSION: Ten days of EET increases the capacity of skeletal muscle to oxidize fatty acids similarly in AAW vs. CW. These data suggest the use of EET as an effective treatment against obesity in AAW. Supported in part by NIH DK56112 and NIH 1 R21 DK065183
General note	Presented to the faculty of the School of Health and Human Performance.
General note	Advisor: Ronald N. Cortright
Dissertation note	M.A. East Carolina University 2004
Bibliography note	Includes bibliographical references (leaves 61-65).
Genre/form	Academic theses.
Genre/form	Academic theses.
Genre/form	Thèses et écrits académiques.

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