Effects of seven days of training on NOS-dependent nutritive exchange in young and aged men / by Christopher Evans.
| Author/creator | Evans, Christopher author. |
| Other author | Hickner, Robert C., degree supervisor. |
| Other author | East Carolina University. Department of Exercise and Sport Science. |
| Format | Theses and dissertations |
| Production | 2004. |
| Description | xi, 87 leaves : illustrations, forms ; 28 cm |
| Supplemental Content | Access via ScholarShip |
| Subjects |
| Summary | Aging is the leading cause of cardiovascular disease. Impaired nutritive exchange is associated with factors that contribute to cardiovascular disease. Aging is also associated with impaired nutritive exchange. Past research indicates that training may improve nutritive exchange. The purpose of this study was to determine if aged males are responsive to short-term aerobic training with respect to the nitric oxide synthase (NOS)- dependent vasodilation pathway. Nutritive exchange, measured by the microdialysis technique, was examined in the vastus lateralis of sedentary aged men (n=8) and sedentary young men (n=8) before and after 7 days of endurance training. Analysis showed that both groups are responsive to the NO donor sodium nitroprusside (P[less-than].001) and inhibition of nitric oxide synthase by L-NMMA (P=.016). A main effect for age existed in response to sodium nitroprusside, with the aged group being more responsive than the young group to this NO donor (P[less-than].05). A trend toward a training effect existed in response to NOS stimulation by acetylcholine (P=.07). The response of the ethanol outflow/inflow ratio (inversely related to nutritive exchange) to L-NMMA was increased after seven days of training in the aged, but not the young, group. The NO signaling pathway downstream of NOS appears to be upregulated in aged males in comparison to young males. Seven days of aerobic cycle ergometry training improves response to NOS inhibition in aged, but not young, males. |
| General note | Presented to the faculty of the Department of Exercise and Sport Science. |
| General note | Advisor: Robert C. Hickner |
| Dissertation note | M.A. East Carolina University 2004 |
| Bibliography note | Includes bibliographical references (leaves 48-50). |
| Genre/form | Academic theses. |
| Genre/form | Academic theses. |
| Genre/form | Thèses et écrits académiques. |
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|---|---|---|---|---|
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