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035 a| (Sirsi) o180688750;

035 a| (OCoLC)180688750;

049 a| EREE;

050 4 a| QP601b| .J64 2006;

100 1 a| Johnson, Emily,e| author.=| ^A756810;

245 14 a| The effects of nitric oxide on lipolysis in obese women before and after 10 days of endurance training /c| by Emily Johnson.;

264 0 c| 2006.;

300 a| 87 leaves :b| illustrations, forms ;c| 28 cm;

336 a| textb| txt2| rdacontent;

337 a| unmediatedb| n2| rdamedia;

338 a| volumeb| nc2| rdacarrier;

502 b| M.A.c| East Carolina Universityd| 2006;

500 a| Presented to the faculty of the Department of Exercise and Sport Science.;

500 a| Advisor: Robert C. Hickner;

520 3 a| Obesity is a serious condition that leads to disorders such as hypertension, Type 2 diabetes, and hypercholesterolemia. Nitric oxide (NO) has been shown to inhibit lipolysis. In addition, obese individuals have more nitric oxide synthase (NOS) content compared to lean. It was the purpose of this study to evaluate the effects of NO on regional lipolysis in obese women before and after ten days of aerobic exercise training. Lipolysis was determined using the microdialysis technique. Three probes were inserted into the abdominal subcutaneous adipose tissue (AAT) and femoral subcutaneous adipose tissue (FAT). Lipolysis was evaluated under non-stimulated, (3-adrenergic stimulated, and NOS inhibited, and exercise conditions. Subjects exercised on a cycle ergometer for an hour per day 10 days. Non-stimulated resting lipolysis did not change in response to exercise training in either the AAT (105.5±16.0 [mu]M PRE; 143.8±27.9 [mu]M POST) (p=0.20) or FAT 109.5±12.4 [mu]M PRE; 133.9±25.0 [mu]M POST) (p=0.20). In AAT, dialysate glycerol concentration was higher with NOS inhibition than in the non-stimulated control probe before (168.6±29.3 [mu]M NOS; 103.9±8.7 [mu]M CON; p=0.04) and after (199.6±33.4 [mu]M NOS; 128.18 16.77 [mu]M CON; p=0.05) training. In FAT, NO only suppressed resting lipolysis before (180.49±36.39 [mu]M NOS; 122.15± 15.48 [mu]M CON; p=0.03), but not after (150.43±29.8 [mu]M NOS 115.32±12.9 [mu]M CON, p=0.26) training compared to the control probe. Under near maximal stimulation (IL: NOS inhibition and padrenergic stimulation), dialysate glycerol was higher than in the probe perfused with isopřnaline, a padrenergic stimulator, before (384.12±44.4 pM IL, 205.6±25.1 [mu]M CON, p[less-than]0.001) and after (371.5±25.8 [mu]M IL, 131.6±8.6 [mu]M CON, p[less-than]0.001) training in AAT. The same was true with FAT before (340.8±43.6 [mu]lM IL, 241.3±25.0 [mu]M CON, p[less-than]0.001) and after (324.3±27.23 [mu]M IL, 216.2±24.6 [mu]M CON, p[less-than]0.01) training. No training effect was observed in any ofthe conditions. These results indicate that 10 days of exercise does provide a great enough stimulus to alter lipolysis in obese premenopausal women.;

504 a| Includes bibliographical references (leaves 46-47).;

650 0 a| Lipolysis.=| ^A263433;

650 0 a| Nitric oxide.=| ^A437814;

650 0 a| Adipose tissues.=| ^A76060;

650 0 a| Obesity in women.=| ^A466827;

650 0 a| Exercise for women.=| ^A501;

650 0 a| Overweight womenx| Physiology.=| ^A295011;

650 7 a| Adipose tissues.2| fast0| (OCoLC)fst00796650;

650 7 a| Exercise for women.2| fast0| (OCoLC)fst00918045;

650 7 a| Lipolysis.2| fast0| (OCoLC)fst00999397;

650 7 a| Nitric oxide.2| fast0| (OCoLC)fst01037984;

650 7 a| Obesity in women.2| fast0| (OCoLC)fst01042775;

655 7 a| Academic theses.2| fast0| (OCoLC)fst01726453;

655 7 a| Academic theses.2| lcgft;

655 7 a| Thèses et écrits académiques.2| rvmgf0| (CaQQLa)RVMGF-000001173;

700 1 a| Hickner, Robert C.,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Exercise and Sport Science.?| UNAUTHORIZED;

856 41 z| Access via ScholarShipu| http://hdl.handle.net/10342/10065;

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999 a| ASK AT SPECIAL COLLECTIONS DESKw| ASISc| 1i| MQ2266392l| JSCJTHDm| JOYNERr| Ys| Yt| JSCJTHDu| 11/3/2007x| ETDz| JSPECCOLLo| .STAFF. 0;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 1271222-3001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 6/23/2023x| ETDz| JERESOURCE;

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The effects of nitric oxide on lipolysis in obese women before and after 10 days of endurance training / by Emily Johnson.

Author/creator	Johnson, Emily author.
Other author	Hickner, Robert C., degree supervisor.
Other author	East Carolina University. Department of Exercise and Sport Science.
Format	Theses and dissertations
Production	2006.
Description	87 leaves : illustrations, forms ; 28 cm
Supplemental Content	Access via ScholarShip
Subjects	Lipolysis. Nitric oxide. Adipose tissues. Obesity in women. Exercise for women. Overweight women--Physiology.

Summary	Obesity is a serious condition that leads to disorders such as hypertension, Type 2 diabetes, and hypercholesterolemia. Nitric oxide (NO) has been shown to inhibit lipolysis. In addition, obese individuals have more nitric oxide synthase (NOS) content compared to lean. It was the purpose of this study to evaluate the effects of NO on regional lipolysis in obese women before and after ten days of aerobic exercise training. Lipolysis was determined using the microdialysis technique. Three probes were inserted into the abdominal subcutaneous adipose tissue (AAT) and femoral subcutaneous adipose tissue (FAT). Lipolysis was evaluated under non-stimulated, (3-adrenergic stimulated, and NOS inhibited, and exercise conditions. Subjects exercised on a cycle ergometer for an hour per day 10 days. Non-stimulated resting lipolysis did not change in response to exercise training in either the AAT (105.5±16.0 [mu]M PRE; 143.8±27.9 [mu]M POST) (p=0.20) or FAT 109.5±12.4 [mu]M PRE; 133.9±25.0 [mu]M POST) (p=0.20). In AAT, dialysate glycerol concentration was higher with NOS inhibition than in the non-stimulated control probe before (168.6±29.3 [mu]M NOS; 103.9±8.7 [mu]M CON; p=0.04) and after (199.6±33.4 [mu]M NOS; 128.18 16.77 [mu]M CON; p=0.05) training. In FAT, NO only suppressed resting lipolysis before (180.49±36.39 [mu]M NOS; 122.15± 15.48 [mu]M CON; p=0.03), but not after (150.43±29.8 [mu]M NOS 115.32±12.9 [mu]M CON, p=0.26) training compared to the control probe. Under near maximal stimulation (IL: NOS inhibition and padrenergic stimulation), dialysate glycerol was higher than in the probe perfused with isopřnaline, a padrenergic stimulator, before (384.12±44.4 pM IL, 205.6±25.1 [mu]M CON, p[less-than]0.001) and after (371.5±25.8 [mu]M IL, 131.6±8.6 [mu]M CON, p[less-than]0.001) training in AAT. The same was true with FAT before (340.8±43.6 [mu]lM IL, 241.3±25.0 [mu]M CON, p[less-than]0.001) and after (324.3±27.23 [mu]M IL, 216.2±24.6 [mu]M CON, p[less-than]0.01) training. No training effect was observed in any ofthe conditions. These results indicate that 10 days of exercise does provide a great enough stimulus to alter lipolysis in obese premenopausal women.
General note	Presented to the faculty of the Department of Exercise and Sport Science.
General note	Advisor: Robert C. Hickner
Dissertation note	M.A. East Carolina University 2006
Bibliography note	Includes bibliographical references (leaves 46-47).
Genre/form	Academic theses.
Genre/form	Academic theses.
Genre/form	Thèses et écrits académiques.

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