Effect of 5-thio-D-glucose on reproduction in male mice : histological, histochemical and fertility studies / by Kenneth Burgwin Fick.
| Author/creator | Fick, Kenneth Burgwin author. |
| Other author | Simpson, Everett C., degree supervisor. |
| Other author | East Carolina University. Department of Biology. |
| Format | Theses and dissertations |
| Production | 1978. |
| Description | viii, 52 leaves : plates ; 28 cm |
| Supplemental Content | Access via ScholarShip |
| Subjects |
| Summary | Sexually mature male ICR strain mice were fed 5-thio-D-glucose daily by gavage and the effects of this treatment on testis and sex accessory gland histology, androgen biosynthesis, and breeding performance were determined. Histological observations of the testes showed multinucleated cells in peripheral seminiferous tubules as early as four weeks. Testes taken from animals treated for six weeks showed multinucleated cells in seminiferous tubules located throughout the entire organ. Histological examination of sex accessory glands from experimental animals were identical to controls. Androgen biosynthesis within the testis of treated animals was unaffected by the drug. Breeding performance was impaired in animals receiving the drug for six weeks, and normal fecundity was not regained until nine weeks following the end of drug administration. |
| Local note | Joyner-"Presented to the faculty of the Department of Biology ... in partial fulfillment of the requirements for the degree Master of Science in Biology." |
| General note | Presented to the Faculty of the Department of Biology. |
| General note | Advisor: Everett C. Simpson |
| Dissertation note | M.S. East Carolina University |
| Bibliography note | Includes bibliographical references (leaves 47-52). |
| Genre/form | Academic theses. |
| Genre/form | Academic theses. |
| Genre/form | Thèses et écrits académiques. |
Availability
| Library | Location | Call Number | Status | Item Actions |
|---|---|---|---|---|
| Joyner | University Archives | ASK AT SPECIAL COLLECTIONS DESK | ✔ Available | Request Material |
| Electronic Resources | Access Content Online | ✔ Available |