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LEADER 03009cam 2200457 a 4500

001 ocn436968376;

003 OCoLC;

005 20141212051321.0;

008 090904s2010 njuaf b 001 0 eng ;

010 a| 2009037093;

020 a| 9780470293423 (cloth);

020 a| 047029342X (cloth);

035 a| (Sirsi) o436968376;

035 a| (OCoLC)436968376;

042 a| pcc;

049 a| NEHH;

050 00 a| RC523b| .B24 2010;

060 10 a| WT 155b| B117 2010;

082 00 a| 618.97/68312| 22;

245 00 a| BACE :b| lead target for orchestrated therapy of Alzheimer's disease /c| edited by Varghese John.;

300 a| xvi, 250 pages, 16 unnumbered pages of plates :b| illustrations (some color) ;c| 25 cm;

336 a| text2| rdacontent;

337 a| unmediated2| rdamedia;

338 a| volume2| rdacarrier;

504 a| Includes bibliographical references and index.;

505 0 a| BACE : APP processing, and signal transduction in Alzheimer's disease / Dale E. Bredesen and Edward H. Koo -- Identification of BACE as a target in Alzheimer's disease / Robert L. Heinrikson and Sukanto Sinha -- BACE biological assays / Alfredo G. Tomasselli and Michael J. Bienkowski -- Peptidic, peptidomimetic, and HTS based BACE inhibitors / James P. Beck and Dustin J. Mergott -- Fragment-based approaches for identification of BACE inhibitors / Andreas Kuglstatter and Michael Hennig -- Structure-based drug design of BACE inhibitors : technical and practical aspects of preparation, 3-dimensional structure, and computational analysis / Felix F. Vajdos, Veerabahu Shanmugasundaram, and Alfredo G. Tomasselli -- Pharmacological models for preclinical testing : from mouse to dog to non-human primates / Jason L. Eriksen, Michael Paul Murphy, and Elizabeth Head -- Adsorption, distribution, metabolism, excretion (ADME), efficacy, and toxicology for BACE inhibitors / Ishrut Hussain and Emmanuel Demont -- Clinical trials for disease-modifying drugs such as BACE inhibitors / Henry H. Hsu -- Future strategies for development of novel BACE inhibitors : anti-APP B-site antibody and APP binding small molecule approaches for Alzheimer's disease / Beka Solomon ... [et al.].;

650 0 a| Alzheimer's diseasex| Chemotherapy.=| ^A12721;

650 0 a| Aspartic proteinasesx| Inhibitorsx| Therapeutic use.=| ^A1017260;

650 0 a| Amyloid beta-protein precursor.=| ^A867936;

650 12 a| Alzheimer Diseasex| drug therapy.=| ^A932641;

650 22 a| Amyloid Precursor Protein Secretasesx| pharmacology.=| ^A1018087;

650 22 a| Amyloid Precursor Protein Secretasesx| therapeutic use.=| ^A1018088;

700 1 a| John, Varghese,d| 1958-=| ^A1015674;

994 a| C0b| NEH;

590 a| Laupus-WCP;

096 a| WT 155 B117 2010;

596 a| 4;

998 a| 2264687;

999 a| WT 155 B117 2010w| NLMc| 1i| 31740007288651d| 6/30/2015f| 6/30/2015g| 2l| HSLBKm| HSLp| $99.95r| Ys| Yt| HBKu| 4/28/2010x| BOOKz| HSTACKSo| .STAFF. herc;

BACE : lead target for orchestrated therapy of Alzheimer's disease / edited by Varghese John.

Other author	John, Varghese, 1958-
Format	Book
Publication Info	Hoboken, N.J. : John Wiley & Sons, ©2010.
Description	xvi, 250 pages, 16 unnumbered pages of plates : illustrations (some color) ; 25 cm
Subjects	Alzheimer's disease--Chemotherapy. Aspartic proteinases--Inhibitors. --Therapeutic use. Amyloid beta-protein precursor. Alzheimer Disease--drug therapy. Amyloid Precursor Protein Secretases--pharmacology. Amyloid Precursor Protein Secretases--therapeutic use.

Contents	BACE : APP processing, and signal transduction in Alzheimer's disease / Dale E. Bredesen and Edward H. Koo -- Identification of BACE as a target in Alzheimer's disease / Robert L. Heinrikson and Sukanto Sinha -- BACE biological assays / Alfredo G. Tomasselli and Michael J. Bienkowski -- Peptidic, peptidomimetic, and HTS based BACE inhibitors / James P. Beck and Dustin J. Mergott -- Fragment-based approaches for identification of BACE inhibitors / Andreas Kuglstatter and Michael Hennig -- Structure-based drug design of BACE inhibitors : technical and practical aspects of preparation, 3-dimensional structure, and computational analysis / Felix F. Vajdos, Veerabahu Shanmugasundaram, and Alfredo G. Tomasselli -- Pharmacological models for preclinical testing : from mouse to dog to non-human primates / Jason L. Eriksen, Michael Paul Murphy, and Elizabeth Head -- Adsorption, distribution, metabolism, excretion (ADME), efficacy, and toxicology for BACE inhibitors / Ishrut Hussain and Emmanuel Demont -- Clinical trials for disease-modifying drugs such as BACE inhibitors / Henry H. Hsu -- Future strategies for development of novel BACE inhibitors : anti-APP B-site antibody and APP binding small molecule approaches for Alzheimer's disease / Beka Solomon ... [et al.].
Local note	Laupus-WCP
Bibliography note	Includes bibliographical references and index.
LCCN	2009037093
ISBN	9780470293423 (cloth)
ISBN	047029342X (cloth)

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Library	Location	Call Number	Status	Item Actions
Laupus	Books - Stacks	WT 155 B117 2010	✔ Available	Place Hold

BACE : lead target for orchestrated therapy of Alzheimer's disease / edited by Varghese John.

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