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001 ocm10898587;

003 OCoLC;

005 20230725092754.0;

008 840629s1984 xx a bm 000 0 eng d;

035 a| (Sirsi) o10898587;

035 a| (OCoLC)10898587;

049 a| EREE;

050 4 a| RG629.F45b| B37x 1984;

100 1 a| Barrow, Richard Dowell,c| II,e| author.?| UNAUTHORIZED;

245 10 a| Effect of ethanol on thymidine incorporation in chick neural tissue /c| by Richard Dowell Barrow, II.;

264 0 c| [1984];

300 a| vi, 32 leaves :b| illustrations ;c| 28 cm;

336 a| textb| txt2| rdacontent;

337 a| unmediatedb| n2| rdamedia;

338 a| volumeb| nc2| rdacarrier;

502 b| M.S.c| East Carolina Universityd| 1984;

500 a| "Presented to the faculty of the Department of Biology ... in partial fulfillment of the requirements for the degree Master of Science in Biology.";

500 a| Advisor: Gerhard W. Kalmus;

520 3 a| Maternal ethanol consumption during pregnancy has been demonstrated to result in deformity of the developing fetus. This condition has been labeled Fetal Alcohol Syndrome (FAS) and is characterized by facial deformity, neural defects, small birth size, and other malformations. Ethanol has been shown to be highly teratogenic in most of the animal models (rat, mouse, sheep and chick embryo) that have been studied. The current research was an attempt to establish the effect of ethanol on the processes of DNA replication by studying thymidine incorporation into chick neural tissue. Firstly, it was determined if ethanol effected the rate of thymidine incorporation into DNA and if so, was it dose related? Secondaly, if ethanol did effect thymidine incorporation into DNA, which step of incorporation was affected? Results demonstrate that ethanol adversely influences chick embryo development. Ethanol exposure in-ovo resulted in a reduction in viability, embryo weight and brain weight. A reduction in the amount of thymidine incorporated into DNA has also been demonstrated. Further study is required to determine at which step in the DNA synthesis does ethanol exhibit its influence.;

504 a| Includes bibliographical references (leaves 30-32).;

650 0 a| Fetal alcohol spectrum disorders.=| ^A9833;

650 0 a| Thymidine.=| ^A187750;

650 2 a| Fetal Alcohol Spectrum Disorders0| (DNLM)D063647=| ^A1205587;

650 2 a| Thymidine0| (DNLM)D013936=| ^A1345696;

655 2 a| Academic Dissertation.0| (DNLM)D019478?| UNAUTHORIZED;

650 7 a| Fetal alcohol spectrum disorders.2| fast0| (OCoLC)fst00923356;

650 7 a| Thymidine.2| fast0| (OCoLC)fst01150531;

655 7 a| Academic theses.2| fast0| (OCoLC)fst01726453;

655 7 a| Academic theses.2| lcgft;

655 7 a| Thèses et écrits académiques.2| rvmgf0| (CaQQLa)RVMGF-000001173;

700 1 a| Kalmus, Gerhard W.,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Biology.=| ^A637467;

856 41 z| Access via ScholarShipu| http://hdl.handle.net/10342/11375;

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Effect of ethanol on thymidine incorporation in chick neural tissue / by Richard Dowell Barrow, II.

Author/creator	Barrow, Richard Dowell author.
Other author	Kalmus, Gerhard W., degree supervisor.
Other author	East Carolina University. Department of Biology.
Format	Theses and dissertations
Production	[1984]
Description	vi, 32 leaves : illustrations ; 28 cm
Supplemental Content	Access via ScholarShip
Subjects	Fetal alcohol spectrum disorders. Thymidine. Fetal Alcohol Spectrum Disorders Thymidine

Summary	Maternal ethanol consumption during pregnancy has been demonstrated to result in deformity of the developing fetus. This condition has been labeled Fetal Alcohol Syndrome (FAS) and is characterized by facial deformity, neural defects, small birth size, and other malformations. Ethanol has been shown to be highly teratogenic in most of the animal models (rat, mouse, sheep and chick embryo) that have been studied. The current research was an attempt to establish the effect of ethanol on the processes of DNA replication by studying thymidine incorporation into chick neural tissue. Firstly, it was determined if ethanol effected the rate of thymidine incorporation into DNA and if so, was it dose related? Secondaly, if ethanol did effect thymidine incorporation into DNA, which step of incorporation was affected? Results demonstrate that ethanol adversely influences chick embryo development. Ethanol exposure in-ovo resulted in a reduction in viability, embryo weight and brain weight. A reduction in the amount of thymidine incorporated into DNA has also been demonstrated. Further study is required to determine at which step in the DNA synthesis does ethanol exhibit its influence.
General note	"Presented to the faculty of the Department of Biology ... in partial fulfillment of the requirements for the degree Master of Science in Biology."
General note	Advisor: Gerhard W. Kalmus
Dissertation note	M.S. East Carolina University 1984
Bibliography note	Includes bibliographical references (leaves 30-32).
Genre/form	Academic theses.
Genre/form	Academic theses.
Genre/form	Thèses et écrits académiques.

Effect of ethanol on thymidine incorporation in chick neural tissue / by Richard Dowell Barrow, II.

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