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035 a| (Sirsi) o755098534;

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040 a| NEHc| NEHd| UtOrBLW;

049 a| NEHH;

100 1 a| Amato, Christina I.?| UNAUTHORIZED;

245 14 a| The role of the proximal small Intestine in improvements in diabetes resolution and Insulin sensitivity following bariatric surgery in type 2 diabetes /c| by Christina I. Amato.;

260 a| [Greenville, N.C.] :b| East Carolina University,c| 2011.;

300 a| 49 pages :b| digital, PDF file;

336 a| text2| rdacontent;

337 a| computer2| rdamedia;

338 a| online resource2| rdacarrier;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| M.S.c| East Carolina Universityd| 2011.;

500 a| Presented to the faculty of the College of Health and Human Performance.;

500 a| Advisor: Timothy P. Gavin.;

500 a| Title from PDF t.p. (viewed September 12, 2011).;

520 3 a| Bariatric surgery is an effective, rapid, and durable treatment for obesity and type 2 diabetes mellitus (T2DM). Roux-en Y Gastric Bypass (RYGB) resolves T2DM in 80% of cases, while gastric banding (LAGB) resolves T2DM in only 45%. One significant difference between RYGB and LAGB is the bypassing of the proximal small intestine in RYGB. Inadequate insulin secretion and insulin resistance are well known contributors to T2DM and both improve following RYGB. To determine if RYGB produces greater improvements in insulin secretion and insulin sensitivity than LAGB in T2DM, we studied obese, T2DM, Caucasian women who underwent RYGB (N=9) or LAGB (N=3). Insulin secretion (AIRg) and insulin sensitivity (Si) were measured pre- and 1-wk post-surgery by Minimal Model analysis following an insulin modified intravenous glucose tolerance test (IVGTT). Post-surgery analysis at 1-wk eliminates the potential contribution of differences in weight loss or food consumption as these are rigorously controlled for 1 wk following these surgical procedures. There was a trend (p = 0.053) for an increase in Si from pre-surgery to 1-wk post-surgery, but there was no difference in Si between surgical groups (RYGB, Pre: 0.85 ± 0.15 and 1-wk: 2.30 ± 0.43) and (LAGB, Pre: 1.32 ± 0.26 and 1-wk: 1.67± 0.60). There was a trend for an Interaction (p = 0.056) in AIRg with an increase in RYGB (Pre: 42.0±23.3 and 1-wk: 94.7 ± 52.6), but decrease among LAGB (Pre: 519.7 ± 392.9 and 1-wk: 391.8 ± 291.6) with surgery. There was also a trend (p = 0.067) for a greater AIRg in LAGB compared to RYGB regardless of surgery status. These results in obese, T2DM, Caucasian women suggest that insulin sensitivity may be increased similarly in RYGB and LAGB questioning the role of the proximal small intestine bypass in the reversal of insulin sensitivity following bariatric surgery. In contrast, improvements in insulin secretion may be greater in RYGB than LAGB. Additional gastric banding patients are required to provide adequate power for statistical analysis.;

504 a| Includes bibliographical references.;

650 2 a| Bariatric Surgery.=| ^A1058112;

650 2 a| Obesityx| surgery.=| ^A944603;

650 2 a| Diabetes Mellitus, Type 2.=| ^A942040;

650 2 a| Gastric Bypassx| methods.=| ^A939351;

650 2 a| Intestine, Small.=| ^A922158;

650 2 a| Insulin.=| ^A918866;

650 2 a| Female.=| ^A1058014;

650 2 a| Postoperative Carex| methods.=| ^A925495;

650 2 a| Preoperative Carex| methods.=| ^A925496;

653 a| Health Sciences;

653 a| Physiology;

700 1 a| Gavin, Timothy P.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Physiology.?| UNAUTHORIZED;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/3629;

949 a| Click on web addressw| ASISh| JOYNER101;

949 a| Click on web addressw| ASISh| HSL111;

994 a| C0b| NEH;

096 a| WD 210;

596 a| 1 4;

998 a| 2580624;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 2580624-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 9/30/2011x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 2580624-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 9/30/2011x| ETDz| HERESOURCE;

The role of the proximal small Intestine in improvements in diabetes resolution and Insulin sensitivity following bariatric surgery in type 2 diabetes / by Christina I. Amato.

Author/creator	Amato, Christina I.
Other author	Gavin, Timothy P.
Other author	East Carolina University. Department of Physiology.
Format	Theses and dissertations
Publication Info	[Greenville, N.C.] : East Carolina University, 2011.
Description	49 pages : digital, PDF file
Supplemental Content	Access via ScholarShip
Subjects	Bariatric Surgery. Obesity--surgery. Diabetes Mellitus, Type 2. Gastric Bypass--methods. Intestine, Small. Insulin. Female. Postoperative Care--methods. Preoperative Care--methods.

Summary	Bariatric surgery is an effective, rapid, and durable treatment for obesity and type 2 diabetes mellitus (T2DM). Roux-en Y Gastric Bypass (RYGB) resolves T2DM in 80% of cases, while gastric banding (LAGB) resolves T2DM in only 45%. One significant difference between RYGB and LAGB is the bypassing of the proximal small intestine in RYGB. Inadequate insulin secretion and insulin resistance are well known contributors to T2DM and both improve following RYGB. To determine if RYGB produces greater improvements in insulin secretion and insulin sensitivity than LAGB in T2DM, we studied obese, T2DM, Caucasian women who underwent RYGB (N=9) or LAGB (N=3). Insulin secretion (AIRg) and insulin sensitivity (Si) were measured pre- and 1-wk post-surgery by Minimal Model analysis following an insulin modified intravenous glucose tolerance test (IVGTT). Post-surgery analysis at 1-wk eliminates the potential contribution of differences in weight loss or food consumption as these are rigorously controlled for 1 wk following these surgical procedures. There was a trend (p = 0.053) for an increase in Si from pre-surgery to 1-wk post-surgery, but there was no difference in Si between surgical groups (RYGB, Pre: 0.85 ± 0.15 and 1-wk: 2.30 ± 0.43) and (LAGB, Pre: 1.32 ± 0.26 and 1-wk: 1.67± 0.60). There was a trend for an Interaction (p = 0.056) in AIRg with an increase in RYGB (Pre: 42.0±23.3 and 1-wk: 94.7 ± 52.6), but decrease among LAGB (Pre: 519.7 ± 392.9 and 1-wk: 391.8 ± 291.6) with surgery. There was also a trend (p = 0.067) for a greater AIRg in LAGB compared to RYGB regardless of surgery status. These results in obese, T2DM, Caucasian women suggest that insulin sensitivity may be increased similarly in RYGB and LAGB questioning the role of the proximal small intestine bypass in the reversal of insulin sensitivity following bariatric surgery. In contrast, improvements in insulin secretion may be greater in RYGB than LAGB. Additional gastric banding patients are required to provide adequate power for statistical analysis.
General note	Presented to the faculty of the College of Health and Human Performance.
General note	Advisor: Timothy P. Gavin.
General note	Title from PDF t.p. (viewed September 12, 2011).
Dissertation note	M.S. East Carolina University 2011.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

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The role of the proximal small Intestine in improvements in diabetes resolution and Insulin sensitivity following bariatric surgery in type 2 diabetes / by Christina I. Amato.

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