Tools

LEADER 03535cam 2200517Ia 4500

001 ocn794394397;

003 OCoLC;

005 20141212030015.0;

006 m d ;

007 cr bn|||||||||;

008 120529s2012 ncua ob 000 0 eng d;

035 a| (Sirsi) o794394397;

035 a| (OCoLC)794394397;

040 a| EREc| EREd| EREd| UtOrBLW;

049 a| EREE;

090 a| QP601;

100 1 a| Raymer, Dustin K.?| UNAUTHORIZED;

245 10 a| Regulation of lipolysis by [beta]-adrenergic activation and exercise in obese African-American and Caucasian women /c| by Dustin K. Raymer.;

260 a| [Greenville, N.C.] :b| East Carolina University,c| 2012.;

300 a| 62 pages :b| illustrations, digital, PDF file;

336 a| text2| rdacontent;

337 a| computer2| rdamedia;

338 a| online resource2| rdacarrier;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| M.S.c| East Carolina Universityd| 2012.;

500 a| Presented to the faculty of the Department of Kinesiology.;

500 a| Advisor: Robert Hickner.;

500 a| Title from PDF t.p. (viewed July 23, 2012).;

520 3 a| African-American women (AAW) are twice as likely to be obese as Caucasian women (CW); however, previous in-vitro studies have shown that AAW have higher densities of beta-adrenergic receptors (B-AR) in the subcutaneous (SC) adipose tissue and an increased lipolytic response to B-AR stimulation when compared to CW. There are no in-vivo studies to help resolve this apparent contradiction between in-vitro lipolytic response and the incidence of obesity. The purpose of this study is therefore to determine if AAW, as compared to CW, have a larger lipolytic response to pharmacological (isoproterenol) and physiological (exercise) stimulation. Methods: 33 obese women (16 AAW; 17 CW) participated in the microdialysis (MD) study. MD consisted of two probes placed in SC abdominal adipose tissue and perfused with either isoproterenol (ISO) or a control solution. Dialysate glycerol (index of lipolysis) was measured from probes at rest and, from the control probe, during exercise. Results: Dialysate glycerol increased 384.9% in AAW and 191.2% in CW in response to ISO (p=0.046 AAW vs CW). Dialysate glycerol increased 66 [mu]mol/L in AAW and 84 [mu]mol/L in CW in response to exercise (p=0.94 AAW vs CW). Conclusion: AAW have a higher lipolytic response to pharmacological B-AR stimulation, but have a similar lipolytic response to exercise, as compared to CW. These findings suggest that lipolytic response to B-AR stimulation and exercise are likely not contributing factors to the higher incidence of obesity in AAW as compared to CW.;

504 a| Includes bibliographical references.;

650 0 a| Lipolysisx| Research.=| ^A263433;

650 0 a| Beta adrenoceptors.=| ^A1122775;

650 0 a| Exercisex| Physiological aspects.=| ^A5960;

650 0 a| Obesity in women.=| ^A466827;

653 a| Health sciences;

653 a| Demography;

700 1 a| Hickner, Robert C.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Kinesiology.?| UNAUTHORIZED;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/3880;

949 o| jgml;

994 a| C0b| ERE;

596 a| 1 4;

998 a| 3063814;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 3063814-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 5/29/2012x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 3063814-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 5/29/2012x| ETDz| HERESOURCE;

Regulation of lipolysis by [beta]-adrenergic activation and exercise in obese African-American and Caucasian women / by Dustin K. Raymer.

Author/creator	Raymer, Dustin K.
Other author	Hickner, Robert C.
Other author	East Carolina University. Department of Kinesiology.
Format	Theses and dissertations
Publication Info	[Greenville, N.C.] : East Carolina University, 2012.
Description	62 pages : illustrations, digital, PDF file
Supplemental Content	Access via ScholarShip
Subjects	Lipolysis--Research. Beta adrenoceptors. Exercise--Physiological aspects. Obesity in women.

Summary	African-American women (AAW) are twice as likely to be obese as Caucasian women (CW); however, previous in-vitro studies have shown that AAW have higher densities of beta-adrenergic receptors (B-AR) in the subcutaneous (SC) adipose tissue and an increased lipolytic response to B-AR stimulation when compared to CW. There are no in-vivo studies to help resolve this apparent contradiction between in-vitro lipolytic response and the incidence of obesity. The purpose of this study is therefore to determine if AAW, as compared to CW, have a larger lipolytic response to pharmacological (isoproterenol) and physiological (exercise) stimulation. Methods: 33 obese women (16 AAW; 17 CW) participated in the microdialysis (MD) study. MD consisted of two probes placed in SC abdominal adipose tissue and perfused with either isoproterenol (ISO) or a control solution. Dialysate glycerol (index of lipolysis) was measured from probes at rest and, from the control probe, during exercise. Results: Dialysate glycerol increased 384.9% in AAW and 191.2% in CW in response to ISO (p=0.046 AAW vs CW). Dialysate glycerol increased 66 [mu]mol/L in AAW and 84 [mu]mol/L in CW in response to exercise (p=0.94 AAW vs CW). Conclusion: AAW have a higher lipolytic response to pharmacological B-AR stimulation, but have a similar lipolytic response to exercise, as compared to CW. These findings suggest that lipolytic response to B-AR stimulation and exercise are likely not contributing factors to the higher incidence of obesity in AAW as compared to CW.
General note	Presented to the faculty of the Department of Kinesiology.
General note	Advisor: Robert Hickner.
General note	Title from PDF t.p. (viewed July 23, 2012).
Dissertation note	M.S. East Carolina University 2012.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

Availability

Library	Location	Call Number	Status	Item Actions
	Electronic Resources	Access Content Online	✔ Available

Regulation of lipolysis by [beta]-adrenergic activation and exercise in obese African-American and Caucasian women / by Dustin K. Raymer.

Click here for more information about this title

Availability