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001 ocn810178227;

003 OCoLC;

005 20141212032703.0;

006 m d ;

007 cr bn|||||||||;

008 120918s2012 ncu ob 000 0 eng d;

035 a| (Sirsi) o810178227;

035 a| (OCoLC)810178227;

049 a| EREE;

090 a| QP624.5.R48;

100 1 a| Chmielewski, Jeffrey Patrick.?| UNAUTHORIZED;

245 10 a| Drosophila Psf2 has a role in chromosome condensation /c| by Jeffrey Patrick Chmielewski.;

260 a| [Greenville, N.C.] :b| East Carolina University,c| 2012.;

300 a| 90 pages :b| illustrations (some color), digital, PDF file;

336 a| text2| rdacontent;

337 a| computer2| rdamedia;

338 a| online resource2| rdacarrier;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| M.S.c| East Carolina Universityd| 2012.;

500 a| Presented to the faculty of the Department of Biology.;

500 a| Advisor: Tim Christensen.;

500 a| Title from PDF t.p. (viewed Sept. 26, 2012).;

520 3 a| The condensation state of chromosomes is a critical parameter in multiple processes within the cell. Failures in the maintenance of appropriate condensation states may lead to genomic instability, mis-expression of genes, and a number of disease states. During cell proliferation, replication of DNA represents an ongoing challenge for chromosome packaging as DNA must be unpackaged for replication and then faithfully repackaged. An integral member of the DNA replication machinery is the GINS complex which has been shown to stabilize the CMG complex which is required for processivity of the Mcm2-7 helicase complex during S phase. Through examination of the phenotypes associated with a null mutation in Psf2, a member of the evolutionarily conserved GINS complex, we find that Drosophila Psf2 likely has a role in establishing chromosome condensation and that the defects associated with this mis-condensation impact M phase progression, genomic stability, and transcriptional regulation.;

504 a| Includes bibliographical references.;

650 0 a| DNA replication.=| ^A825742;

650 0 a| Chromosome replication.=| ^A112835;

650 0 a| Drosophila.=| ^A54199;

653 a| Biology;

653 a| Genetics;

700 1 a| Christensen, Tim.=| ^A1389912;

710 2 a| East Carolina University.b| Department of Biology.=| ^A637467;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/3965;

949 o| jgml;

994 a| C0b| ERE;

596 a| 1 4;

998 a| 3108462;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 3108462-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 9/18/2012x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 3108462-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 9/18/2012x| ETDz| HERESOURCE;

Drosophila Psf2 has a role in chromosome condensation / by Jeffrey Patrick Chmielewski.

Author/creator	Chmielewski, Jeffrey Patrick
Other author	Christensen, Tim.
Other author	East Carolina University. Department of Biology.
Format	Theses and dissertations
Publication Info	[Greenville, N.C.] : East Carolina University, 2012.
Description	90 pages : illustrations (some color), digital, PDF file
Supplemental Content	Access via ScholarShip
Subjects	DNA replication. Chromosome replication. Drosophila.

Summary	The condensation state of chromosomes is a critical parameter in multiple processes within the cell. Failures in the maintenance of appropriate condensation states may lead to genomic instability, mis-expression of genes, and a number of disease states. During cell proliferation, replication of DNA represents an ongoing challenge for chromosome packaging as DNA must be unpackaged for replication and then faithfully repackaged. An integral member of the DNA replication machinery is the GINS complex which has been shown to stabilize the CMG complex which is required for processivity of the Mcm2-7 helicase complex during S phase. Through examination of the phenotypes associated with a null mutation in Psf2, a member of the evolutionarily conserved GINS complex, we find that Drosophila Psf2 likely has a role in establishing chromosome condensation and that the defects associated with this mis-condensation impact M phase progression, genomic stability, and transcriptional regulation.
General note	Presented to the faculty of the Department of Biology.
General note	Advisor: Tim Christensen.
General note	Title from PDF t.p. (viewed Sept. 26, 2012).
Dissertation note	M.S. East Carolina University 2012.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

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Drosophila Psf2 has a role in chromosome condensation / by Jeffrey Patrick Chmielewski.

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