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035 a| (Sirsi) o810191444;

035 a| (OCoLC)810191444;

049 a| EREE;

090 a| RC661.I6;

100 1 a| Ernst, Jacob Matthew.?| UNAUTHORIZED;

245 10 a| Skeletal muscle insulin sensitivity and duration of type 2 diabetes mellitus /c| by Jacob Matthew Ernst.;

260 a| [Greenville, N.C.] :b| East Carolina University,c| 2012.;

300 a| 60 pages :b| illustrations, digital, PDF file;

336 a| text2| rdacontent;

337 a| computer2| rdamedia;

338 a| online resource2| rdacarrier;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| M.S.c| East Carolina Universityd| 2012.;

500 a| Presented to the faculty of the Department of Exercise Physiology.;

500 a| Advisor: Timothy Gavin.;

500 a| Title from PDF t.p. (viewed Sept. 19, 2012).;

520 3 a| Type 2 Diabetes Mellitus (T2DM) resolution following Roux-en Y gastric bypass (RYGB) surgery is reduced in patients with longer duration of T2DM and preliminary data suggest this may be mechanistically linked to lower pre-RYGB insulin sensitivity. Insulin sensitivity is reduced in T2DM. Skeletal muscle accounts for 60-80% of insulin mediated glucose disposal. PURPOSE: It was hypothesized that insulin sensitivity would be lowest in T2DM patients with long-duration (LD; [greater than or equal to] 8 y) compared to short-duration (SD; < 8 y). METHODS: Insulin sensitivity (Si) and the acute response to glucose (AIRg) were measured following an insulin modified intravenous glucose tolerance test (IVGTT) using Minimal Model analysis in T2DM patients (N = 14). RESULTS: There was a significant (p = 0.010) difference in Si between short and long T2DM duration (LD: 0.47 ± 0.7; SD: 1.94 ± 0.96 min/mU/ml) and a significant correlation between Si and duration of T2DM (r = -0.70; p = 0.010). There was a significant difference in AIRg between groups. There was a significant correlation between HbA1c (an index of glycemic control) and Si (r = -0.76; p = 0.002), but not between HbA1c and AIRg (r = -0.36; p = 0.204). CONCLUSIONS: Insulin sensitivity is lower in T2DM patients with longer duration of T2DM. Clinically, poor glycemic control in long duration T2DM may be partially explained by reduced skeletal muscle insulin sensitivity.;

504 a| Includes bibliographical references.;

650 0 a| Diabetesx| Research.=| ^A125962;

650 0 a| Insulin.=| ^A3807;

650 0 a| Musculoskeletal system.=| ^A4330;

650 0 a| Gastric bypass.=| ^A879542;

653 a| Kinesiology;

653 a| Physiology;

700 1 a| Gavin, Timothy P.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Kinesiology.?| UNAUTHORIZED;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/3950;

949 o| jgml;

994 a| C0b| ERE;

596 a| 1 4;

998 a| 3108474;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 3108474-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 9/18/2012x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 3108474-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 9/18/2012x| ETDz| HERESOURCE;

Skeletal muscle insulin sensitivity and duration of type 2 diabetes mellitus / by Jacob Matthew Ernst.

Author/creator	Ernst, Jacob Matthew
Other author	Gavin, Timothy P.
Other author	East Carolina University. Department of Kinesiology.
Format	Theses and dissertations
Publication Info	[Greenville, N.C.] : East Carolina University, 2012.
Description	60 pages : illustrations, digital, PDF file
Supplemental Content	Access via ScholarShip
Subjects	Diabetes--Research. Insulin. Musculoskeletal system. Gastric bypass.

Summary	Type 2 Diabetes Mellitus (T2DM) resolution following Roux-en Y gastric bypass (RYGB) surgery is reduced in patients with longer duration of T2DM and preliminary data suggest this may be mechanistically linked to lower pre-RYGB insulin sensitivity. Insulin sensitivity is reduced in T2DM. Skeletal muscle accounts for 60-80% of insulin mediated glucose disposal. PURPOSE: It was hypothesized that insulin sensitivity would be lowest in T2DM patients with long-duration (LD; [greater than or equal to] 8 y) compared to short-duration (SD; < 8 y). METHODS: Insulin sensitivity (Si) and the acute response to glucose (AIRg) were measured following an insulin modified intravenous glucose tolerance test (IVGTT) using Minimal Model analysis in T2DM patients (N = 14). RESULTS: There was a significant (p = 0.010) difference in Si between short and long T2DM duration (LD: 0.47 ± 0.7; SD: 1.94 ± 0.96 min/mU/ml) and a significant correlation between Si and duration of T2DM (r = -0.70; p = 0.010). There was a significant difference in AIRg between groups. There was a significant correlation between HbA1c (an index of glycemic control) and Si (r = -0.76; p = 0.002), but not between HbA1c and AIRg (r = -0.36; p = 0.204). CONCLUSIONS: Insulin sensitivity is lower in T2DM patients with longer duration of T2DM. Clinically, poor glycemic control in long duration T2DM may be partially explained by reduced skeletal muscle insulin sensitivity.
General note	Presented to the faculty of the Department of Exercise Physiology.
General note	Advisor: Timothy Gavin.
General note	Title from PDF t.p. (viewed Sept. 19, 2012).
Dissertation note	M.S. East Carolina University 2012.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

Skeletal muscle insulin sensitivity and duration of type 2 diabetes mellitus / by Jacob Matthew Ernst.

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