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001 ocm20611765;

003 OCoLC;

005 20241021155018.0;

008 891108s1987 xx a bm 000 0 eng d;

035 a| (Sirsi) o20611765;

035 a| (OCoLC)20611765;

049 a| EREE;

050 4 a| QP801.P68b| G73x 1987;

100 1 a| Gravelle-Camelo, Sheryl L.,e| author.?| UNAUTHORIZED;

245 14 a| The effect of hypo and hypercapnia on thromboxane and prostacyclin levels in piglets /c| by Sheryl L. Gravelle-Camelo.;

264 0 c| 1987.;

300 a| iv, 40 leaves :b| illustrations ;c| 28 cm;

336 a| textb| txt2| rdacontent;

337 a| unmediatedb| n2| rdamedia;

338 a| volumeb| nc2| rdacarrier;

502 b| M.S.c| East Carolina Universityd| 1987;

500 a| Submitted to the faculty of the Department of Biology.;

500 a| Advisor: Gerard W. Kalmus;

520 3 a| The purpose of this study was to investigate the effects of typo and hypercapnic induced changes in cerebral bloodflow on the levels of thromboxane B₂ prostacyclin in piglets. Cerebral circulation was measured with a bloodflow probe while the animal was exposed to hypo and hypercapnic conditions. Blood samples were withdrawn from the sagittal sinus of the piglet, and assayed for thromboxane B₂ and prostacyclin by radioimmunoassay. Results demonstrated that CO₂ does affect cerebral bloodflow in the piglet. Hypocapnia results in a decrease in cerebral bloodflow, while hypercapnia causes an Increase. It was also demonstrated that plasma prostaoyolin levels increase under hypercapnic conditions. These results, while not conclusive, are comparable to studies indicating that prostaglandins affect cerebral bloodflow in neonates to a much greater extent than in adults. The more complete understanding of cerebral bloodflow in infants may be Important in developing a treatment to prevent intraventricular hemorrhage, which results in fatality or neurological Impairments in preterm or low birth weight infants.;

504 a| Includes bibliographical references (leaves 37-40).;

650 0 a| Prostaglandinsx| Physiological effect.=| ^A2696;

650 0 a| Prostacyclinx| Physiological effect.=| ^A254706;

650 0 a| Thromboxanesx| Physiological effect.=| ^A13439;

650 0 a| Hypercapnia.=| ^A234752;

650 0 a| Cerebral circulation.=| ^A234753;

650 2 a| Hypercapnia.0| (DNLM)D006935=| ^A1473683;

650 2 a| Cerebrovascular Circulation.0| (DNLM)D002560=| ^A920245;

655 2 a| Academic Dissertation.0| (DNLM)D019478?| UNAUTHORIZED;

650 7 a| Cerebral circulation.2| fast0| (OCoLC)fst00851270;

650 7 a| Hypercapnia.2| fast0| (OCoLC)fst00965729;

650 7 a| Prostacyclinx| Physiological effect.2| fast0| (OCoLC)fst01079459;

650 7 a| Prostaglandinsx| Physiological effect.2| fast0| (OCoLC)fst01079466;

650 7 a| Thromboxanesx| Physiological effect.2| fast0| (OCoLC)fst01150441;

655 7 a| Academic theses.2| fast0| (OCoLC)fst01726453;

655 7 a| Academic theses.2| lcgft;

655 7 a| Thèses et écrits académiques.2| rvmgf0| (CaQQLa)RVMGF-000001173;

700 1 a| Kalmus, Gerhard W.,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Biology.=| ^A637467;

856 41 z| Access via ScholarShipu| http://hdl.handle.net/10342/11166;

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949 a| Click on web addressw| asish| hsl111;

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The effect of hypo and hypercapnia on thromboxane and prostacyclin levels in piglets / by Sheryl L. Gravelle-Camelo.

Author/creator	Gravelle-Camelo, Sheryl L. author.
Other author	Kalmus, Gerhard W., degree supervisor.
Other author	East Carolina University. Department of Biology.
Format	Theses and dissertations
Production	1987.
Description	iv, 40 leaves : illustrations ; 28 cm
Supplemental Content	Access via ScholarShip
Subjects	Prostaglandins--Physiological effect. Prostacyclin--Physiological effect. Thromboxanes--Physiological effect. Hypercapnia. Cerebral circulation. Hypercapnia. Cerebrovascular Circulation.

Summary	The purpose of this study was to investigate the effects of typo and hypercapnic induced changes in cerebral bloodflow on the levels of thromboxane B₂ prostacyclin in piglets. Cerebral circulation was measured with a bloodflow probe while the animal was exposed to hypo and hypercapnic conditions. Blood samples were withdrawn from the sagittal sinus of the piglet, and assayed for thromboxane B₂ and prostacyclin by radioimmunoassay. Results demonstrated that CO₂ does affect cerebral bloodflow in the piglet. Hypocapnia results in a decrease in cerebral bloodflow, while hypercapnia causes an Increase. It was also demonstrated that plasma prostaoyolin levels increase under hypercapnic conditions. These results, while not conclusive, are comparable to studies indicating that prostaglandins affect cerebral bloodflow in neonates to a much greater extent than in adults. The more complete understanding of cerebral bloodflow in infants may be Important in developing a treatment to prevent intraventricular hemorrhage, which results in fatality or neurological Impairments in preterm or low birth weight infants.
General note	Submitted to the faculty of the Department of Biology.
General note	Advisor: Gerard W. Kalmus
Dissertation note	M.S. East Carolina University 1987
Bibliography note	Includes bibliographical references (leaves 37-40).
Genre/form	Academic theses.
Genre/form	Academic theses.
Genre/form	Thèses et écrits académiques.

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The effect of hypo and hypercapnia on thromboxane and prostacyclin levels in piglets / by Sheryl L. Gravelle-Camelo.

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