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035 a| (Sirsi) o857589077;

035 a| (OCoLC)857589077;

049 a| EREE;

090 a| RM666.S714;

100 1 a| Mayo, William Joseph,e| author.?| UNAUTHORIZED;

245 14 a| The effects of statins on mitochondrial function /c| by William Joseph Mayo.;

264 1 a| [Greenville, N.C.] :b| [East Carolina University],c| 2013.;

300 a| 68 pages :b| illustrations (some color);

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

347 a| text fileb| PDFc| 4.13Mb2| rda;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| M.S.c| East Carolina Universityd| 2013.;

500 a| Presented to the faculty of the Department of Kinesiology.;

500 a| Advisor: P. Darrell Neufer.;

500 a| Title from PDF t.p. (viewed October 1, 2013).;

520 3 a| Statins, or 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are among the most commonly prescribed medications in the United States. They are commonly used to treat hypercholesterolemia, a condition in which blood cholesterol is elevated above normal levels. Statins serve as an effective means of lowering blood cholesterol, which is associated with a decreased risk for cardiovascular disease. Patients diagnosed with or at risk of coronary artery disease are therefore commonly prescribed statins in order to prevent the development of plaque induced narrowing of coronary arteries. While well tolerated by most patients, reports indicate that approximately 10.5% of patients suffer from statin induced myopathies. Commonly reported side effects include muscular cramps, stiffness, heaviness, weakness, tendonitis, and decreased power during physical activity. Reports have also emerged of statin induced changes in the function of skeletal muscle mitochondria. These reports provided the impetus for an examination of the possibility that statin induced mitochondrial abnormalities play a role in the etiology of the myopathies reported by patients. This study was therefore designed to test the hypothesis that statins interfere with normal mitochondrial function. Specifically, the purpose was to determine whether seven days of in vivo administration of simvastatin or atorvastatin reduces mitochondrial respiratory capacity, decreases mitochondrial calcium retention capacity, and/or increases mitochondrial H₂O₂ emission potential. Twelve female subjects participated in this study. Subjects underwent a 7-day treatment with either 40-mg simvastatin or 80-mg atorvastatin, administered orally. Muscle biopsies were obtained from the rectus femoris muscle at four time points: pre-/post-statin consumption on day one of the study, and pre-/post-statin consumption one week later. Skeletal muscle samples were permeabilized and measurements of mitochondrial respiratory capacity, calcium retention capacity, and H₂O₂ emission potential were performed. The results of this study provide little evidence to support the hypothesis that statins administered in vivo over the course of a seven day treatment interfere with normal mitochondrial function. No significant treatment effect emerged either acutely (2-3 hours following statin treatment) or chronically (after a seven day treatment). Statins seemed to have little to no effect on mitochondrial respiratory capacity, calcium retention capacity, and H₂O₂ emission potential during the seven day treatment. The results of this study suggest that the deleterious effects of statin exposure reported in the literature are not a consequence of acute or short term (7d) changes in mitochondrial function with commencement of statin therapy. However, in vitro studies demonstrate that acute statin exposure can indeed negatively affect mitochondrial respiratory capacity, calcium retention capacity, and H₂O₂ emission potential (C-T Lin & PD Neufer, unpublished data). Further studies will be required to elucidate the exact nature of statin induced mitochondrial abnormalities in humans and their role in the etiology of statin induced myopathies.;

504 a| Includes bibliographical references.;

650 0 a| Statins (Cardiovascular agents)=| ^A719564;

650 0 a| Mitochondrial pathology.=| ^A576127;

653 a| Physiology;

700 1 a| Neufer, P. Darrell,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Kinesiology.?| UNAUTHORIZED;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/4201;

949 o| jgml;

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998 a| 3361972;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 3361972-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 9/4/2013x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 3361972-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 9/4/2013x| ETDz| HERESOURCE;

The effects of statins on mitochondrial function / by William Joseph Mayo.

Author/creator	Mayo, William Joseph author.
Other author	Neufer, P. Darrell, degree supervisor.
Other author	East Carolina University. Department of Kinesiology.
Format	Theses and dissertations
Publication	[Greenville, N.C.] : [East Carolina University], 2013.
Description	68 pages : illustrations (some color)
Supplemental Content	Access via ScholarShip
Subjects	Statins (Cardiovascular agents) Mitochondrial pathology.

Summary	Statins, or 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are among the most commonly prescribed medications in the United States. They are commonly used to treat hypercholesterolemia, a condition in which blood cholesterol is elevated above normal levels. Statins serve as an effective means of lowering blood cholesterol, which is associated with a decreased risk for cardiovascular disease. Patients diagnosed with or at risk of coronary artery disease are therefore commonly prescribed statins in order to prevent the development of plaque induced narrowing of coronary arteries. While well tolerated by most patients, reports indicate that approximately 10.5% of patients suffer from statin induced myopathies. Commonly reported side effects include muscular cramps, stiffness, heaviness, weakness, tendonitis, and decreased power during physical activity. Reports have also emerged of statin induced changes in the function of skeletal muscle mitochondria. These reports provided the impetus for an examination of the possibility that statin induced mitochondrial abnormalities play a role in the etiology of the myopathies reported by patients. This study was therefore designed to test the hypothesis that statins interfere with normal mitochondrial function. Specifically, the purpose was to determine whether seven days of in vivo administration of simvastatin or atorvastatin reduces mitochondrial respiratory capacity, decreases mitochondrial calcium retention capacity, and/or increases mitochondrial H₂O₂ emission potential. Twelve female subjects participated in this study. Subjects underwent a 7-day treatment with either 40-mg simvastatin or 80-mg atorvastatin, administered orally. Muscle biopsies were obtained from the rectus femoris muscle at four time points: pre-/post-statin consumption on day one of the study, and pre-/post-statin consumption one week later. Skeletal muscle samples were permeabilized and measurements of mitochondrial respiratory capacity, calcium retention capacity, and H₂O₂ emission potential were performed. The results of this study provide little evidence to support the hypothesis that statins administered in vivo over the course of a seven day treatment interfere with normal mitochondrial function. No significant treatment effect emerged either acutely (2-3 hours following statin treatment) or chronically (after a seven day treatment). Statins seemed to have little to no effect on mitochondrial respiratory capacity, calcium retention capacity, and H₂O₂ emission potential during the seven day treatment. The results of this study suggest that the deleterious effects of statin exposure reported in the literature are not a consequence of acute or short term (7d) changes in mitochondrial function with commencement of statin therapy. However, in vitro studies demonstrate that acute statin exposure can indeed negatively affect mitochondrial respiratory capacity, calcium retention capacity, and H₂O₂ emission potential (C-T Lin & PD Neufer, unpublished data). Further studies will be required to elucidate the exact nature of statin induced mitochondrial abnormalities in humans and their role in the etiology of statin induced myopathies.
General note	Presented to the faculty of the Department of Kinesiology.
General note	Advisor: P. Darrell Neufer.
General note	Title from PDF t.p. (viewed October 1, 2013).
Dissertation note	M.S. East Carolina University 2013.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

The effects of statins on mitochondrial function / by William Joseph Mayo.

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