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LEADER 03801ctm 2200565 i 4500

001 ocm22146623;

003 OCoLC;

005 20230725092800.0;

008 900726s1974 xx a bm 000 0 eng d;

035 a| (Sirsi) o22146623;

035 a| (OCoLC)22146623;

049 a| EREE;

050 4 a| QK898.G45b| B37x 1974;

100 1 a| Barnes, James Nixon,e| author.?| UNAUTHORIZED;

245 10 a| Gibberellie acid mediated changes in cholesterol levels in the albino rat /c| by James Nixon Barnes.;

264 0 c| 1974.;

300 a| iv, 34 leaves :b| illustrations ;c| 28 cm;

336 a| textb| txt2| rdacontent;

337 a| unmediatedb| n2| rdamedia;

338 a| volumeb| nc2| rdacarrier;

500 a| Title on abstract: Gibberellic acid-mediate changes in cholesterol in albino rats.;

500 a| Thesis received May 1990.;

502 b| M.A.c| East Carolina Universityd| 1974;

500 a| Submitted to the faculty of the Department of Biology.;

500 a| Advisor: Graham J. Davis;

520 3 a| Gibberellic acid (GA) is a plant hormone that affects stem elongation and often flowering, germination, and leaf shape change. Indirect evidence from the work of others led us to suspect that GA may affect sterol metabolism. Cycocel, a plant growth řgulant, blocks production of GA in plants and synthesis of cholesterol in rat liver extracts. Smith, Kline, and French compound 7997, an animal steroid inhibitor, has been found to block floral induction and elongation from exogenous GA. The albino rat was chosen for these studies because of simple and well-established analytical procedures and similarities in sterol metabolic pathways to those of higher plants. Total serum cholesterol levels were assayed colorimetrically 2, 4, and 6 hours after IP injections of citric acid-phosphate buffer, pH 6.9. Dosages of GA were 1, 2, and 3 mg GA/500 gm body weight; control buffer solutions were injected at a volume equal to the volume that would be required for GA treatments. Buffer alone resulted in increased cholesterol levels while all GA treatments depressed these high levels to below normal. Results from the treatments were significant at the 0.05 level, no significance with time or interaction of time and treatment were found.;

504 a| Includes bibliographical references (leaves 28-30).;

650 0 a| Gibberellins.=| ^A48235;

650 0 a| Plant hormonesx| Research.=| ^A50314;

650 2 a| Gibberellins0| (DNLM)D005875=| ^A1458943;

655 2 a| Academic Dissertation.0| (DNLM)D019478?| UNAUTHORIZED;

650 7 a| Gibberellins.2| fast0| (OCoLC)fst00942523;

650 7 a| Plant hormonesx| Research.2| fast0| (OCoLC)fst01065483;

655 7 a| Academic theses.2| fast0| (OCoLC)fst01726453;

655 7 a| Academic theses.2| lcgft;

655 7 a| Thèses et écrits académiques.2| rvmgf0| (CaQQLa)RVMGF-000001173;

700 1 a| Davis, Graham J.,e| degree supervisor.=| ^A86589;

710 2 a| East Carolina University.b| Department of Biology.=| ^A637467;

856 41 z| Access via ScholarShipu| http://hdl.handle.net/10342/11155;

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949 a| Click on web addressw| asish| hsl111;

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998 a| 356540;

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Gibberellie acid mediated changes in cholesterol levels in the albino rat / by James Nixon Barnes.

Author/creator	Barnes, James Nixon author.
Other author	Davis, Graham J., degree supervisor.
Other author	East Carolina University. Department of Biology.
Format	Theses and dissertations
Production	1974.
Description	iv, 34 leaves : illustrations ; 28 cm
Supplemental Content	Access via ScholarShip
Subjects	Gibberellins. Plant hormones--Research. Gibberellins

Summary	Gibberellic acid (GA) is a plant hormone that affects stem elongation and often flowering, germination, and leaf shape change. Indirect evidence from the work of others led us to suspect that GA may affect sterol metabolism. Cycocel, a plant growth řgulant, blocks production of GA in plants and synthesis of cholesterol in rat liver extracts. Smith, Kline, and French compound 7997, an animal steroid inhibitor, has been found to block floral induction and elongation from exogenous GA. The albino rat was chosen for these studies because of simple and well-established analytical procedures and similarities in sterol metabolic pathways to those of higher plants. Total serum cholesterol levels were assayed colorimetrically 2, 4, and 6 hours after IP injections of citric acid-phosphate buffer, pH 6.9. Dosages of GA were 1, 2, and 3 mg GA/500 gm body weight; control buffer solutions were injected at a volume equal to the volume that would be required for GA treatments. Buffer alone resulted in increased cholesterol levels while all GA treatments depressed these high levels to below normal. Results from the treatments were significant at the 0.05 level, no significance with time or interaction of time and treatment were found.
General note	Title on abstract: Gibberellic acid-mediate changes in cholesterol in albino rats.
General note	Thesis received May 1990.
General note	Submitted to the faculty of the Department of Biology.
General note	Advisor: Graham J. Davis
Dissertation note	M.A. East Carolina University 1974
Bibliography note	Includes bibliographical references (leaves 28-30).
Genre/form	Academic theses.
Genre/form	Academic theses.
Genre/form	Thèses et écrits académiques.

Gibberellie acid mediated changes in cholesterol levels in the albino rat / by James Nixon Barnes.

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