Tools

LEADER 03782cam 2200589Ii 4500

001 ocn910852196;

003 OCoLC;

005 20151103143354.0;

006 m o d ;

007 cr bn|||||||||;

008 150608s2015 ncua ob 000 0 eng d;

035 a| (Sirsi) o910852196;

035 a| (OCoLC)910852196;

049 a| EREE;

100 1 a| Fender, Alexander W.,e| author.?| UNAUTHORIZED;

245 10 a| Role of Notch signaling in tumorigenesis, stemness, and epithelial to mesenchymal transtion in colorectal cancer /c| by Alexander W. Fender.;

264 1 a| [Greenville, N.C.] :b| [East Carolina University],c| 2015.;

300 a| 75 pages :b| illustrations (some color);

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

347 a| text fileb| PDFc| 1.01Mb2| rda;

490 1 a| ECU Brody School of Medicine thesis;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| M.S.c| East Carolina Universityd| 2015.;

500 a| Presented to the faculty of the Department of Biomedical Sciences.;

500 a| Advisor: George Sigounas.;

500 a| Title from PDF t.p. (viewed June 08, 2015).;

520 3 a| Colorectal cancer is the third most commonly diagnosed cancer in both men and women in the United States. Surgical resection and combination chemotherapy are often used for treatment, but in later stages of the disease, these therapies are often unsuccessful. Previous studies have revealed that circulating cancer cells with stem-cell like properties are associated with disease progression and metastatic potential. The Notch signaling pathway has been found to be critical for proliferation and proper functioning in the stem cell compartment of the colon. Preliminary studies from our lab have shown a marked increase in Notch-1 levels from colon tumor tissue as compared to normal colon tissue. This study hypothesizes that overexpression of Notch-1 signaling in colon cancer results in enhanced Epithelial to Mesenchymal Transition (EMT) and stemness mediated by other Notch family members via the Jagged-1 ligand. Overexpression of Notch-1 resulted in a cell phenotype which resembles that of a cancer stem cell, with a slower dividing time, and enhanced aggressiveness. Furthermore, cells with constitutively active Notch-1 overexpressed proteins associated with stemness and EMT such as CD44 and Slug. The results which we obtained provide an indication that Notch signaling plays a significant role in the upregulation of EMT and stemness in colon cancer.;

504 a| Includes bibliographical references.;

650 2 a| Colorectal Neoplasmsx| metabolism.=| ^A1273099;

650 2 a| Receptors, Notchx| metabolism.=| ^A1273119;

650 2 a| Signal Transduction.=| ^A925743;

650 2 a| Transforming Growth Factor betax| metabolism.=| ^A936065;

653 a| Biology;

653 a| Biochemistry;

653 a| Molecular biology;

700 1 a| Sigounas, George,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| Brody School of Medicine.b| Office of Research and Graduate Studies.b| Biomedical Sciences. ?| UNAUTHORIZED;

830 0 a| ECU Brody School of Medicine thesis.=| ^A964744;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/4948;

949 a| Click on web addressw| ASISh| JOYNER101;

949 a| Click on web addressw| ASISh| HSL111;

949 o| jdjr;

994 a| C0b| ERE;

096 a| WI 529;

596 a| 1 4;

998 a| 3766647;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 3766647-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 6/8/2015x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 3766647-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 6/8/2015x| ETDz| HERESOURCE;

Role of Notch signaling in tumorigenesis, stemness, and epithelial to mesenchymal transtion in colorectal cancer / by Alexander W. Fender.

Author/creator	Fender, Alexander W. author.
Other author	Sigounas, George, degree supervisor.
Other author	Brody School of Medicine. Office of Research and Graduate Studies. Biomedical Sciences.
Format	Theses and dissertations
Publication	[Greenville, N.C.] : [East Carolina University], 2015.
Description	75 pages : illustrations (some color)
Supplemental Content	Access via ScholarShip
Subjects	Colorectal Neoplasms--metabolism. Receptors, Notch--metabolism. Signal Transduction. Transforming Growth Factor beta--metabolism.

Series	ECU Brody School of Medicine thesis ECU Brody School of Medicine thesis. ^A964744
Summary	Colorectal cancer is the third most commonly diagnosed cancer in both men and women in the United States. Surgical resection and combination chemotherapy are often used for treatment, but in later stages of the disease, these therapies are often unsuccessful. Previous studies have revealed that circulating cancer cells with stem-cell like properties are associated with disease progression and metastatic potential. The Notch signaling pathway has been found to be critical for proliferation and proper functioning in the stem cell compartment of the colon. Preliminary studies from our lab have shown a marked increase in Notch-1 levels from colon tumor tissue as compared to normal colon tissue. This study hypothesizes that overexpression of Notch-1 signaling in colon cancer results in enhanced Epithelial to Mesenchymal Transition (EMT) and stemness mediated by other Notch family members via the Jagged-1 ligand. Overexpression of Notch-1 resulted in a cell phenotype which resembles that of a cancer stem cell, with a slower dividing time, and enhanced aggressiveness. Furthermore, cells with constitutively active Notch-1 overexpressed proteins associated with stemness and EMT such as CD44 and Slug. The results which we obtained provide an indication that Notch signaling plays a significant role in the upregulation of EMT and stemness in colon cancer.
General note	Presented to the faculty of the Department of Biomedical Sciences.
General note	Advisor: George Sigounas.
General note	Title from PDF t.p. (viewed June 08, 2015).
Dissertation note	M.S. East Carolina University 2015.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

Availability

Library	Location	Call Number	Status	Item Actions
	Electronic Resources	Access Content Online	✔ Available

Role of Notch signaling in tumorigenesis, stemness, and epithelial to mesenchymal transtion in colorectal cancer / by Alexander W. Fender.

Click here for more information about this title

Availability