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007 cr bn|||||||||;

008 150608s2015 ncua ob 000 0 eng d;

035 a| (Sirsi) o910850822;

035 a| (OCoLC)910850822;

049 a| EREE;

090 a| QD181.C4;

100 1 a| Swartz, Brian W.,e| author.?| UNAUTHORIZED;

245 10 a| Viability of cerium oxide nanoparticles as a radioprotector against proton radiation for non-malignant cells /c| by Brian W. Swartz.;

264 1 a| [Greenville, N.C.] :b| [East Carolina University],c| 2015.;

300 a| 91 pages :b| illustrations (some color);

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

347 a| text fileb| PDFc| 1.85Mb2| rda;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| Ph.D.c| East Carolina Universityd| 2015.;

500 a| Presented to the faculty of the Department of Physics.;

500 a| Advisor: Jefferson Shinpaugh.;

500 a| Title from PDF t.p. (viewed July 24, 2015).;

520 3 a| Radiation therapy is a prevalent cancer treatment therapy. The goal is to kill all tumor cells while minimizing damage to healthy cells and new methods that can accomplish this goal are continually being investigated. Cerium Oxide (CeO₂) or ceria nanoparticles have recently shown to act as a radioprotector for non-malignant cells while sensitizing tumor cells to x-rays. However, research is required to determine if the same benefits are present for heavy charged-particle radiation. This dissertation research investigates the efficacy of ceria nanoparticles (CNPs) as a radioprotector of normal cells irradiated with 3-4 MeV protons at doses of 1-6 Gy in the East Carolina University Accelerator Laboratory. The CNPs were synthesized at the University of Central Florida Nanoscience Technology Center and were transferred to ECU. Cell viability was measured with the Microculture Tetrazolium (MTT) assay 24 and 48 hours post irradiation. DNA damage was determined using the Terminal Uridine Nick-End Labeling (TUNEL) assay. While showing promise for potential radioprotection of non-malignant cells using both assays, the MTT assay results were less conclusive and require further research. The TUNEL assay results are preliminary but show that CNPs reduce DNA damage to non-malignant cells compared to those cells which were not treated.;

504 a| Includes bibliographical references.;

650 0 a| Cerium oxides.=| ^A1272705;

650 0 a| Cancerx| Radiotherapy.=| ^A139;

650 0 a| Heavy particles (Nuclear physics)=| ^A320311;

653 a| Biophysics;

653 a| Physics;

700 1 a| Shinpaugh, Jefferson L.,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Physics.?| UNAUTHORIZED;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/4964;

949 o| jgml;

994 a| C0b| ERE;

596 a| 1 4;

998 a| 3766729;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 3766729-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 6/9/2015x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 3766729-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 6/9/2015x| ETDz| HERESOURCE;

Viability of cerium oxide nanoparticles as a radioprotector against proton radiation for non-malignant cells / by Brian W. Swartz.

Author/creator	Swartz, Brian W. author.
Other author	Shinpaugh, Jefferson L., degree supervisor.
Other author	East Carolina University. Department of Physics.
Format	Theses and dissertations
Publication	[Greenville, N.C.] : [East Carolina University], 2015.
Description	91 pages : illustrations (some color)
Supplemental Content	Access via ScholarShip
Subjects	Cerium oxides. Cancer--Radiotherapy. Heavy particles (Nuclear physics)

Summary	Radiation therapy is a prevalent cancer treatment therapy. The goal is to kill all tumor cells while minimizing damage to healthy cells and new methods that can accomplish this goal are continually being investigated. Cerium Oxide (CeO₂) or ceria nanoparticles have recently shown to act as a radioprotector for non-malignant cells while sensitizing tumor cells to x-rays. However, research is required to determine if the same benefits are present for heavy charged-particle radiation. This dissertation research investigates the efficacy of ceria nanoparticles (CNPs) as a radioprotector of normal cells irradiated with 3-4 MeV protons at doses of 1-6 Gy in the East Carolina University Accelerator Laboratory. The CNPs were synthesized at the University of Central Florida Nanoscience Technology Center and were transferred to ECU. Cell viability was measured with the Microculture Tetrazolium (MTT) assay 24 and 48 hours post irradiation. DNA damage was determined using the Terminal Uridine Nick-End Labeling (TUNEL) assay. While showing promise for potential radioprotection of non-malignant cells using both assays, the MTT assay results were less conclusive and require further research. The TUNEL assay results are preliminary but show that CNPs reduce DNA damage to non-malignant cells compared to those cells which were not treated.
General note	Presented to the faculty of the Department of Physics.
General note	Advisor: Jefferson Shinpaugh.
General note	Title from PDF t.p. (viewed July 24, 2015).
Dissertation note	Ph.D. East Carolina University 2015.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

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Viability of cerium oxide nanoparticles as a radioprotector against proton radiation for non-malignant cells / by Brian W. Swartz.

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