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245 00 a| BACEh| [electronic resource] :b| lead target for orchestrated therapy of Alzheimer's disease /c| edited by Varghese John.;

260 a| Hoboken, N.J. :b| John Wiley & Sons,;

300 a| xvi, 250 p., [16] p. of plates :b| ill. (some col.) ;c| 25 cm.;

504 a| Includes bibliographical references and index.;

505 0 a| BACE : APP processing, and signal transduction in Alzheimer's disease / Dale E. Bredesen and Edward H. Koo -- Identification of BACE as a target in Alzheimer's disease / Robert L. Heinrikson and Sukanto Sinha -- BACE biological assays / Alfredo G. Tomasselli and Michael J. Bienkowski -- Peptidic, peptidomimetic, and HTS based BACE inhibitors / James P. Beck and Dustin J. Mergott -- Fragment-based approaches for identification of BACE inhibitors / Andreas Kuglstatter and Michael Hennig -- Structure-based drug design of BACE inhibitors : technical and practical aspects of preparation, 3-dimensional structure, and computational analysis / Felix F. Vajdos, Veerabahu Shanmugasundaram, and Alfredo G. Tomasselli -- Pharmacological models for preclinical testing : from mouse to dog to non-human primates / Jason L. Eriksen, Michael Paul Murphy, and Elizabeth Head -- Adsorption, distribution, metabolism, excretion (ADME), efficacy, and toxicology for BACE inhibitors / Ishrut Hussain and Emmanuel Demont -- Clinical trials for disease-modifying drugs such as BACE inhibitors / Henry H. Hsu -- Future strategies for development of novel BACE inhibitors : anti-APP B-site antibody and APP binding small molecule approaches for Alzheimer's disease / Beka Solomon ... [et al.].;

506 a| Available only to authorized users.;

538 a| Mode of access: World Wide Web;

650 0 a| Alzheimer's diseasex| Chemotherapy.=| ^A12721;

650 0 a| Aspartic proteinasesx| Inhibitorsx| Therapeutic use.=| ^A1017260;

650 0 a| Amyloid beta-protein precursor.=| ^A867936;

650 12 a| Alzheimer Diseasex| drug therapy.=| ^A932641;

650 22 a| Amyloid Precursor Protein Secretasesx| pharmacology.=| ^A1018087;

650 22 a| Amyloid Precursor Protein Secretasesx| therapeutic use.=| ^A1018088;

655 0 a| Electronic books.=| ^A491897;

700 1 a| John, Varghese,d| 1958-=| ^A1015674;

856 40 z| Full text available from Ebook Central - Academic Completeu| https://ebookcentral.proquest.com/lib/eastcarolina/detail.action?docID=496021;

947 a| (OCoLC)ocn436968376;

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BACE lead target for orchestrated therapy of Alzheimer's disease / edited by Varghese John.

Other author	John, Varghese, 1958-
Format	Electronic
Publication Info	Hoboken, N.J. : John Wiley & Sons,
Description	xvi, 250 p., [16] p. of plates : ill. (some col.) ; 25 cm.
Supplemental Content	Full text available from Ebook Central - Academic Complete
Subjects	Alzheimer's disease--Chemotherapy. Aspartic proteinases--Inhibitors. --Therapeutic use. Amyloid beta-protein precursor. Alzheimer Disease--drug therapy. Amyloid Precursor Protein Secretases--pharmacology. Amyloid Precursor Protein Secretases--therapeutic use.

Contents	BACE : APP processing, and signal transduction in Alzheimer's disease / Dale E. Bredesen and Edward H. Koo -- Identification of BACE as a target in Alzheimer's disease / Robert L. Heinrikson and Sukanto Sinha -- BACE biological assays / Alfredo G. Tomasselli and Michael J. Bienkowski -- Peptidic, peptidomimetic, and HTS based BACE inhibitors / James P. Beck and Dustin J. Mergott -- Fragment-based approaches for identification of BACE inhibitors / Andreas Kuglstatter and Michael Hennig -- Structure-based drug design of BACE inhibitors : technical and practical aspects of preparation, 3-dimensional structure, and computational analysis / Felix F. Vajdos, Veerabahu Shanmugasundaram, and Alfredo G. Tomasselli -- Pharmacological models for preclinical testing : from mouse to dog to non-human primates / Jason L. Eriksen, Michael Paul Murphy, and Elizabeth Head -- Adsorption, distribution, metabolism, excretion (ADME), efficacy, and toxicology for BACE inhibitors / Ishrut Hussain and Emmanuel Demont -- Clinical trials for disease-modifying drugs such as BACE inhibitors / Henry H. Hsu -- Future strategies for development of novel BACE inhibitors : anti-APP B-site antibody and APP binding small molecule approaches for Alzheimer's disease / Beka Solomon ... [et al.].
Bibliography note	Includes bibliographical references and index.
Access restriction	Available only to authorized users.
Technical details	Mode of access: World Wide Web
Genre/form	Electronic books.
LCCN	2009037093
ISBN	9780470293423 (cloth)
ISBN	047029342X (cloth)

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