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245 00 a| Glutamate-related biomarkers in drug development for disorders of the nervous systemh| [electronic resource] :b| workshop summary /c| Diana E. Pankevich, Miriam Davis, and Bruce M. Altevogt, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine of the National Academies.;

260 a| Washington, D.C. :b| National Academies Press,;

300 a| xii, 61 p. :b| ill. (some col.) ;c| 23 cm.;

504 a| Includes bibliographical references (p. 39-43);

506 a| Available only to authorized users.;

520 a| Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. This book investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.;

530 a| Also available online in Open Book format via the National Academies Press home page.;

538 a| Mode of access: World Wide Web;

650 0 a| Biochemical markersv| Congresses.=| ^A1235879;

650 0 a| Drug developmentv| Congresses.=| ^A443888;

650 0 a| Nervous systemx| Diseasesv| Congresses.=| ^A50;

650 0 a| Neuropharmacologyv| Congresses.=| ^A1006037;

655 0 a| Electronic books.=| ^A491897;

700 1 a| Pankevich, Diana E.,d| 1975-=| ^A1036414;

700 1 a| Altevogt, Bruce M.=| ^A1003063;

700 1 a| Davis, Miriam.=| ^A1201516;

710 2 a| Institute of Medicine (U.S.).b| Forum on Neuroscience and Nervous System Disorders.=| ^A1035761;

856 40 z| Full text available from Ebook Central - Academic Completeu| https://ebookcentral.proquest.com/lib/eastcarolina/detail.action?docID=3378800;

947 a| (OCoLC)ocn744284133;

949 a| CLICK ON WEB ADDRESSw| ASISh| JOYNER188;

949 a| CLICK ON WEB ADDRESSw| ASISh| HSL77;

949 a| CLICK ON WEB ADDRESSw| ASISh| JMUSIC60;

596 a| 1 3 4;

998 a| 4098448;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 4098448-1001l| JNETm| JOYNERr| Ys| Yt| JNESSBKu| 1/2/2016x| EBOOKz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 4098448-2001l| HSLELECm| HSLr| Ys| Yt| HEBKu| 1/2/2016x| EBOOKz| HERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 4098448-3001l| MNETm| JMUSICr| Ys| Yt| MNESSBKu| 1/2/2016x| EBOOKz| JERESOURCE;

Glutamate-related biomarkers in drug development for disorders of the nervous system workshop summary / Diana E. Pankevich, Miriam Davis, and Bruce M. Altevogt, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine of the National Academies.

Format	Electronic
Publication Info	Washington, D.C. : National Academies Press,
Description	xii, 61 p. : ill. (some col.) ; 23 cm.
Supplemental Content	Full text available from Ebook Central - Academic Complete
Subjects	Biochemical markers--Congresses. Drug development--Congresses. Nervous system--Diseases. --Congresses. Neuropharmacology--Congresses.

Other author/creator	Pankevich, Diana E., 1975-
Other author/creator	Altevogt, Bruce M.
Other author/creator	Davis, Miriam.
Other author/creator	Institute of Medicine (U.S.). Forum on Neuroscience and Nervous System Disorders.
Abstract	Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. This book investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.
Bibliography note	Includes bibliographical references (p. 39-43)
Access restriction	Available only to authorized users.
Other forms	Also available online in Open Book format via the National Academies Press home page.
Technical details	Mode of access: World Wide Web
Genre/form	Electronic books.
LCCN	2011275018
ISBN	9780309212212
ISBN	0309212219

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