Muscle aging inclusion-body myositis and myopathies / edited by Valerie Askanas and W. King Engel.
| Other author | Askanas, Valerie. |
| Other author | Engel, W. King. |
| Format | Electronic |
| Publication Info | Chichester, West Sussex : Wiley-Blackwell, |
| Description | xii, 250 pages, [8] pages of color plates : illustrations ; 26 cm |
| Supplemental Content | Full text available from Ebook Central - Academic Complete |
| Subjects |
| Contents | Ageing of the human neuromuscular system : pathological aspects / W. King Engel and Valerie Askanas -- Aging of the human neuromuscular system : clinical considerations / W. King Engel and Valerie Askanas -- Aging of the human neuromuscular system : patient vignettes / W. King Engel, Shalini Mahajan, Valerie Askanas -- Mitochondrial changes in ageing with particular reference to muscle, and possible clinical consequences / Salvatore DiMauro, Eric Schon, Michio Hirano -- Protein degradation in ageing cells and mitochondria : relevance to the neuromuscular system / Jenny Ngo and Kelvin J.A. Davies -- Human muscle protein metabolism in relation to exercise and aging : potential therapeutic applications / Micah J. Drummond, Blake B. Rasmussen -- Pathogenesis of sporadic inclusion-body myositis / Valerie Askanas, W. King Engel, Anna Nogalska -- Inflammatory and autoimmune features of inclusion-body myositis / Marinos C. Dalakas -- Sporadic inclusion-body myositis: clinical symptoms, physical findings, and diagnostic investigations / Frank L. Mastaglia -- Pathologic diagnostic criteria of sporadic inclusion-body myositis and hereditary inclusion-body myopathy muscle biopsies / Valerie Askanas and W. King Engel -- Function and mutations of the GNE gene leading to distal myopathy with rimmed vacuoles hereditary inclusion-body myopathy, animal models, and potential treatments / May Christine V. Malicdan, Satoru Noguchi, Ichizo Nishino -- GNE myopathy (hereditary inclusion-body myopathy/distal myopathy with rimmed vacuoles): clinical features and epidemiology / Zohar Argov, Ishizo Nishino, Ikiyo Nonaka -- Consequences of the hereditary inclusion-body myopathy-characteristic GNE mutations on muscle proteins in vivo and in vitro / Aldobrando Broccolini and Massimiliano Mirabella -- Function and structure of VCP mutations leading to inclusion-body myopathy associated with Paget disease of bone and frontotemporal dementia / Cezary Wojcik -- Clinical spectrum of VCP myopathy, Paget disease, and frontotemporal dementia : experimental models and potential treatments / Virginia Kimonis [and others] -- Drosophila and mouse models of hereditary myopathy caused by mutations in VCP / Nisha M. Badders and J. Paul Taylor. |
| Abstract | The aging of society is leading to many challenges across all areas of medicine. The problems of muscle aging have led to a rise in the incidence of less common conditions, which though not terminal are debilitating and frequently progressive, and often underdiagnosed or misdiagnosed. Written by a team of international experts, this landmark book will look at the general clinical problems associated with muscle aging before examining inclusion-body myositis and myopathies, a group of the more important diseases of muscle aging. With case vignettes to aid diagnosis to ensure correct management of an illness. |
| Bibliography note | Includes bibliographical references and index. |
| Access restriction | Available only to authorized users. |
| Technical details | Mode of access: World Wide Web |
| Genre/form | Electronic books. |
| LCCN | 2011029718 |
| ISBN | 9781405196468 (hardcover ; alk. paper) |
| ISBN | 1405196467 |