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010 a| 2011040419;

020 a| 9780470170830 (cloth);

020 a| 0470170832 (cloth);

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245 00 a| Predictive approaches in drug discovery and developmenth| [electronic resource] :b| biomarkers and in vitro/in vivo correlations /c| edited by J. Andrew Williams ... [et al.].;

260 a| Hoboken, N.J. :b| Wiley,;

300 a| xvii, 387 p. :b| ill. ;c| 25 cm.;

490 1 a| Wiley series on technologies for the pharmaceutical industry;

504 a| Includes bibliographical references and index.;

505 0 a| The importance of biomarkers in translational medicine / Joseph Fleishaker -- Fit for purpose validation of biochemical assays : challenges and solutions / Gabriella Szekely-Klepser and Scott Fountain -- Transcriptional profiling in biomarker discovery / Michael E. Burczynski ... [et al.] -- Proteomic biomarker approaches in drug discovery and development / Ruth A. Vanbogelen, Jeffrey D. Thomas, and Diane Alessi -- Application of metabolomics to pharmaceutical research and development / Qiuwei Xu and William H. Schaefer -- Vascular biomarkers and imaging studies / Karin Potthoff, Ulrike Fiedler, and Joachim Drevs -- Cardiovascular biomarkers as examples of success and failure in predicting safety in humans / Simon Authier ... [et al.] -- Use of molecular imaging for receptor occupancy decision making in drug development / R. Paul Maguire -- Biosensors for clinical biomarkers / Sara Tombelli and Marco Mascini -- US regulatory perspective on biomarker development / Rajnikath Madabushi, Lawrence Lesko, and Janet Woodcock -- EU regulatory perspective on biomarkers / Ian Hudson -- Use of biomarkers in drug development : Japanese perspectives / Yoshiaki Uyama ... [et al.] -- In vitro-in vivo correlations of hepatic drug clearance / R. Scott Obach -- The potential of in silico and in vitro approaches to predict in vivo drug-drug interactions and ADMET/TOX properties / Kenneth Bachmann and Sean Ekins -- In vitro-in vivo correlations in drug discovery and development : concepts and applications in toxicology / Rex Denton, Kimberly Brannen, and Buce D. Car -- Assessing the potential for induction of cytochrome P450 enzymes and predicting the in vivo response / Jiunn H. Lin.;

506 a| Available only to authorized users.;

538 a| Mode of access: World Wide Web;

650 0 a| Biochemical markers.=| ^A160152;

650 0 a| Drug development.=| ^A443888;

650 0 a| Pharmaceutical technology.=| ^A234566;

650 12 a| Biomarkers, Pharmacological.=| ^A1205468;

650 12 a| Drug Discovery.=| ^A1013013;

650 22 a| Drug Evaluation, Preclinical.=| ^A938316;

650 22 a| Technology, Pharmaceutical.=| ^A919143;

655 0 a| Electronic books.=| ^A491897;

700 1 a| Williams, J. Andrew.?| UNAUTHORIZED;

830 0 a| Wiley series on technologies for the pharmaceutical industry.=| ^A789954;

856 40 z| Full text available from Ebook Central - Academic Completeu| https://ebookcentral.proquest.com/lib/eastcarolina/detail.action?docID=822092;

949 a| CLICK ON WEB ADDRESSw| ASISh| JOYNER188;

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Predictive approaches in drug discovery and development biomarkers and in vitro/in vivo correlations / edited by J. Andrew Williams ... [et al.].

Other author	Williams, J. Andrew.
Format	Electronic
Publication Info	Hoboken, N.J. : Wiley,
Description	xvii, 387 p. : ill. ; 25 cm.
Supplemental Content	Full text available from Ebook Central - Academic Complete
Subjects	Biochemical markers. Drug development. Pharmaceutical technology. Biomarkers, Pharmacological. Drug Discovery. Drug Evaluation, Preclinical. Technology, Pharmaceutical.

Series	Wiley series on technologies for the pharmaceutical industry Wiley series on technologies for the pharmaceutical industry. ^A789954
Contents	The importance of biomarkers in translational medicine / Joseph Fleishaker -- Fit for purpose validation of biochemical assays : challenges and solutions / Gabriella Szekely-Klepser and Scott Fountain -- Transcriptional profiling in biomarker discovery / Michael E. Burczynski ... [et al.] -- Proteomic biomarker approaches in drug discovery and development / Ruth A. Vanbogelen, Jeffrey D. Thomas, and Diane Alessi -- Application of metabolomics to pharmaceutical research and development / Qiuwei Xu and William H. Schaefer -- Vascular biomarkers and imaging studies / Karin Potthoff, Ulrike Fiedler, and Joachim Drevs -- Cardiovascular biomarkers as examples of success and failure in predicting safety in humans / Simon Authier ... [et al.] -- Use of molecular imaging for receptor occupancy decision making in drug development / R. Paul Maguire -- Biosensors for clinical biomarkers / Sara Tombelli and Marco Mascini -- US regulatory perspective on biomarker development / Rajnikath Madabushi, Lawrence Lesko, and Janet Woodcock -- EU regulatory perspective on biomarkers / Ian Hudson -- Use of biomarkers in drug development : Japanese perspectives / Yoshiaki Uyama ... [et al.] -- In vitro-in vivo correlations of hepatic drug clearance / R. Scott Obach -- The potential of in silico and in vitro approaches to predict in vivo drug-drug interactions and ADMET/TOX properties / Kenneth Bachmann and Sean Ekins -- In vitro-in vivo correlations in drug discovery and development : concepts and applications in toxicology / Rex Denton, Kimberly Brannen, and Buce D. Car -- Assessing the potential for induction of cytochrome P450 enzymes and predicting the in vivo response / Jiunn H. Lin.
Bibliography note	Includes bibliographical references and index.
Access restriction	Available only to authorized users.
Technical details	Mode of access: World Wide Web
Genre/form	Electronic books.
LCCN	2011040419
ISBN	9780470170830 (cloth)
ISBN	0470170832 (cloth)

Predictive approaches in drug discovery and development biomarkers and in vitro/in vivo correlations / edited by J. Andrew Williams ... [et al.].

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