Systems biology in drug discovery and development / edited by Daniel L. Young, Seth Michelson.

Other author Young, Daniel L.
Other author Michelson, Seth.
Format Electronic
Publication InfoHoboken, New Jersey : Wiley, John Wiley & Sons, Inc. Publication , [2012]
Descriptionxvii, 370 pages : illustrations ; 25 cm.
Supplemental ContentFull text available from Ebook Central - Academic Complete
Subjects
Drug development.
Systems biology.
Drug Discovery--methods.
Models, Biological.
Pharmacokinetics.
Pharmacological Processes.
Systems Biology--methods.

SeriesWiley series on Technologies for the Pharmaceutical Industry
Contents Introduction to systems biology in drug discovery and development -- Methods for in silico biology : model construction and analysis -- Methods in in silico biology : modeling feedback dynamics in pathways -- Simulation of population variability in pharmacokinetics -- Applications of systems biology approaches to target identification and validation in drug discovery -- Lead identification and optimization -- The role of core biological motifs in dose-response modeling : an example with switch-like circuits -- Mechanism based pharmacokinetic-pharmacodynamic modeling during discovery and early development -- Developing oncology drugs using virtual patients of vascular tumor diseases -- Systems modeling applied to candidate biomarker identification -- Simulating clinical trials -- Pathway analysis in drug discovery -- Functional mapping for predicting drug response and enabling personalized medicine -- Future outlook of systems biology.
Bibliography noteIncludes bibliographical references and index.
Access restrictionAvailable only to authorized users.
Technical detailsMode of access: World Wide Web
Genre/formElectronic books.
LCCN 2010043475
ISBN9780470261231 (cloth)

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