Tools

LEADER 03530cam 2200529Ii 4500

001 on1001281797;

003 OCoLC;

005 20171114043318.0;

006 m o d ;

007 cr unu||||||||;

008 170816s2017 ncua obm 000 0 eng d;

035 a| (Sirsi) o1001281797;

035 a| (OCoLC)1001281797;

049 a| EREE;

090 a| RS201.N35;

100 1 a| Carlson, Nathan B.,e| author.?| UNAUTHORIZED;

245 10 a| Protection and sensitization of human cells to proton radiation by cerium oxide nanoparticles /c| by Nathan B. Carlson.;

264 1 a| [Greenville, N.C.] :b| [East Carolina University],c| 2017.;

300 a| 119 pages :b| illustrations (chiefly color);

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

347 a| text fileb| PDFc| 6.108 MB2| rda;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| Ph.D.c| East Carolina Universityd| 2017.;

500 a| Presented to the faculty of the Department of Physics;

500 a| Advisor: Jefferson Shinpaugh;

500 a| Title from PDF t.p. (viewed November 7, 2017).;

520 3 a| In radiation therapy for the treatment of cancer, there is demand for novel approaches that will improve tumor cell killing while protecting healthy tissue. One such approach that has shown considerable promise is the application of nanoparticles as radiation sensitizers for tumor cells and as radiation protectants for healthy tissue. In this investigation, cerium oxide nanoparticles (CNPs) obtained from the University of Central Florida's NanoScience Technology Center were studied for their protective effect to charged particle radiation in non-malignant breast cells, and for their sensitizing effect in breast and prostate cancer cell lines. These experiments were conducted at East Carolina University, where human cells were grown in the cell culture facility in the Department of Biology and then irradiated with energetic protons in the Accelerator Laboratory in the Department of Physics. Prior to irradiation, the cells were treated with distinct CNP preparations ranging in concentrations from 10 nanomolar to 10 micromolar, and cell viability was assessed using multiple assays post-irradiation. Radioprotection and radiosensitization were observed for several of the CNP treatments tested. Ultimately, the goal is to find a specific nanoparticle treatment that holds the synergistic effect of enhancing the rate of killing in tumor cells while simultaneously improving the survival of normal cells.;

504 a| Includes bibliographical references.;

650 0 a| Nanoparticles.=| ^A210009;

650 0 a| Radiation-sensitizing agents.=| ^A1233659;

650 0 a| Radiation-protective agents.=| ^A680272;

650 0 a| Radiotherapy.=| ^A612;

650 0 a| Cerium oxides.=| ^A1272705;

653 a| Proton Radiation;

653 a| Clonogenic Assay;

700 1 a| Shinpaugh, Jefferson L.,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Physics.?| UNAUTHORIZED;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/6369;

994 a| C0b| ERE;

596 a| 1 4;

998 a| 4733363;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 4733363-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 8/16/2017x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 4733363-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 8/16/2017x| ETDz| HERESOURCE;

Protection and sensitization of human cells to proton radiation by cerium oxide nanoparticles / by Nathan B. Carlson.

Author/creator	Carlson, Nathan B. author.
Other author	Shinpaugh, Jefferson L., degree supervisor.
Other author	East Carolina University. Department of Physics.
Format	Theses and dissertations
Publication	[Greenville, N.C.] : [East Carolina University], 2017.
Description	119 pages : illustrations (chiefly color)
Supplemental Content	Access via ScholarShip
Subjects	Nanoparticles. Radiation-sensitizing agents. Radiation-protective agents. Radiotherapy. Cerium oxides.

Summary	In radiation therapy for the treatment of cancer, there is demand for novel approaches that will improve tumor cell killing while protecting healthy tissue. One such approach that has shown considerable promise is the application of nanoparticles as radiation sensitizers for tumor cells and as radiation protectants for healthy tissue. In this investigation, cerium oxide nanoparticles (CNPs) obtained from the University of Central Florida's NanoScience Technology Center were studied for their protective effect to charged particle radiation in non-malignant breast cells, and for their sensitizing effect in breast and prostate cancer cell lines. These experiments were conducted at East Carolina University, where human cells were grown in the cell culture facility in the Department of Biology and then irradiated with energetic protons in the Accelerator Laboratory in the Department of Physics. Prior to irradiation, the cells were treated with distinct CNP preparations ranging in concentrations from 10 nanomolar to 10 micromolar, and cell viability was assessed using multiple assays post-irradiation. Radioprotection and radiosensitization were observed for several of the CNP treatments tested. Ultimately, the goal is to find a specific nanoparticle treatment that holds the synergistic effect of enhancing the rate of killing in tumor cells while simultaneously improving the survival of normal cells.
General note	Presented to the faculty of the Department of Physics
General note	Advisor: Jefferson Shinpaugh
General note	Title from PDF t.p. (viewed November 7, 2017).
Dissertation note	Ph.D. East Carolina University 2017.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

Availability

Library	Location	Call Number	Status	Item Actions
	Electronic Resources	Access Content Online	✔ Available

Protection and sensitization of human cells to proton radiation by cerium oxide nanoparticles / by Nathan B. Carlson.

Click here for more information about this title

Availability