Therapeutic and toxicological evaluation of broad-spectrum antimicrobial triclosan as a chemotherapeutic agent / by Mohammad Abdulmohsen Alfhili.
| Author/creator | Alfhili, Mohammad Abdulmohsen author. |
| Other author | Lee, Myon-Hee, degree supervisor. |
| Other author | East Carolina University. Department of Internal Medicine. |
| Format | Theses and dissertations |
| Publication | [Greenville, N.C.] : [East Carolina University], 2019. |
| Description | 272 pages : illustrations (chiefly color). |
| Supplemental Content | Access via ScholarShip |
| Subjects |
| Series | ECU Brody School of Medicine dissertation ECU Brody School of Medicine dissertation. UNAUTHORIZED |
| Summary | Triclosan (TCS) is a phenolic antimicrobial incorporated in personal care products and medical devices. Interest in the antiproliferative properties of TCS has recently grown owing to its antilipogenic effects. Through the studies presented here, we provide an appraisal of TCS as a chemotherapeutic agent by investigating its influence on the growth and survival of lymphoma cells. We also examine the contribution of TCS to the development of anemia; a major side effect of chemotherapy with a prevalence as high as 90% in cancer patients. Finally, we identify nonionic detergents, often used as excipients in drug formulations, as potent inhibitors of TCS in vivo. |
| General note | Presented to the Academic Faculty of the Department of Internal Medicine |
| General note | Advisor: Myon-Hee Lee |
| General note | Title from PDF t.p. (viewed August 30, 2019). |
| Dissertation note | Ph.D. East Carolina University 2019. |
| Bibliography note | Includes bibliographical references. |
| Technical details | System requirements: Adobe Reader. |
| Technical details | Mode of access: World Wide Web. |
Availability
| Library | Location | Call Number | Status | Item Actions |
|---|---|---|---|---|
| Electronic Resources | Access Content Online | ✔ Available |