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245 00 a| Defining the mandate of proteomics in the post-genomics erah| [electronic resource] :b| workshop report /c| Steering Committee for Defining the Mandate of Proteomics in the Post-Genomics Era ; U.S. National Committee for the International Union of Biochemistry and Molecular Biology, Board on International Scientific Organizations, Policy and Global Affairs Division, and Board on Life Sciences, Division of Earth and Life Studies, National Research Council of the National Academies.;

260 a| Washington, D.C. :b| National Academies Press,;

300 a| 1 online resource (1 PDF file (1 v. (various pagings)) :b| ill.);

504 a| Includes bibliographical references.;

506 a| Available only to authorized users.;

520 3 a| Research in proteomics is the next logical step after genomics in understanding life processes at the molecular level. In the largest sense proteomics encompasses knowledge of the structure, function and expression of all proteins in the biochemical or biological contexts of all organisms. Since that is an impossible goal to achieve, at least in our lifetimes, it is appropriate to set more realistic, achievable goals for the field. Up to now, primarily for reasons of feasibility, scientists have tended to concentrate on accumulating information about the nature of proteins and their absolute and relative levels of expression in cells (the primary tools for this have been 2D gel electrophoresis and mass spectrometry). Although these data have been useful and will continue to be so, the information inherent in the broader definition of proteomics must also be obtained if the true promise of the growing field is to be realized. Acquiring this knowledge is the challenge for researchers in proteomics and the means to support these endeavors need to be provided. An attempt has been made to present the major issues confronting the field of proteomics and two clear messages come through in this report. The first is that the mandate of proteomics is and should be much broader than is frequently recognized. The second is that proteomics is much more complicated than sequencing genomes. This will require new technologies but it is highly likely that many of these will be developed. Looking back 10 to 20 years from now, the question is: Will we have done the job wisely or wastefully?;

538 a| Mode of access: World Wide Web;

588 a| Title from PDF t.p. (viewed July 28, 2012).;

650 12 a| Proteomics0| https://id.nlm.nih.gov/mesh/D040901=| ^A937796;

650 22 a| Genomics0| https://id.nlm.nih.gov/mesh/D023281=| ^A936706;

650 22 a| Proteins0| https://id.nlm.nih.gov/mesh/D011506=| ^A918438;

651 2 a| United States0| https://id.nlm.nih.gov/mesh/D014481=| ^A965939;

655 0 a| Electronic books.=| ^A491897;

710 2 a| National Research Council (U.S.).b| Steering Committee for Defining the Mandate of Proteomics in the Post-Genomics Era.=| ^A1330246;

710 2 a| National Research Council (U.S.).b| Board on Life Sciences.=| ^A535504;

710 2 a| U.S. National Committee for the International Union of Biochemistry and Molecular Biology.=| ^A1330747;

856 40 z| Full text available from Ebook Central - Academic Completeu| https://ebookcentral.proquest.com/lib/eastcarolina/detail.action?docID=3376636;

947 a| (OCoLC)614937784;

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Defining the mandate of proteomics in the post-genomics era workshop report / Steering Committee for Defining the Mandate of Proteomics in the Post-Genomics Era ; U.S. National Committee for the International Union of Biochemistry and Molecular Biology, Board on International Scientific Organizations, Policy and Global Affairs Division, and Board on Life Sciences, Division of Earth and Life Studies, National Research Council of the National Academies.

Other author	National Research Council (U.S.). Steering Committee for Defining the Mandate of Proteomics in the Post-Genomics Era.
Other author	National Research Council (U.S.). Board on Life Sciences.
Other author	U.S. National Committee for the International Union of Biochemistry and Molecular Biology.
Format	Electronic
Publication Info	Washington, D.C. : National Academies Press,
Description	1 online resource (1 PDF file (1 v. (various pagings)) : ill.)
Supplemental Content	Full text available from Ebook Central - Academic Complete
Subjects	Proteomics Genomics Proteins United States

Summary	Research in proteomics is the next logical step after genomics in understanding life processes at the molecular level. In the largest sense proteomics encompasses knowledge of the structure, function and expression of all proteins in the biochemical or biological contexts of all organisms. Since that is an impossible goal to achieve, at least in our lifetimes, it is appropriate to set more realistic, achievable goals for the field. Up to now, primarily for reasons of feasibility, scientists have tended to concentrate on accumulating information about the nature of proteins and their absolute and relative levels of expression in cells (the primary tools for this have been 2D gel electrophoresis and mass spectrometry). Although these data have been useful and will continue to be so, the information inherent in the broader definition of proteomics must also be obtained if the true promise of the growing field is to be realized. Acquiring this knowledge is the challenge for researchers in proteomics and the means to support these endeavors need to be provided. An attempt has been made to present the major issues confronting the field of proteomics and two clear messages come through in this report. The first is that the mandate of proteomics is and should be much broader than is frequently recognized. The second is that proteomics is much more complicated than sequencing genomes. This will require new technologies but it is highly likely that many of these will be developed. Looking back 10 to 20 years from now, the question is: Will we have done the job wisely or wastefully?
Bibliography note	Includes bibliographical references.
Access restriction	Available only to authorized users.
Technical details	Mode of access: World Wide Web
Source of description	Title from PDF t.p. (viewed July 28, 2012).
Genre/form	Electronic books.

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