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Biology and engineering of stem cell niches / edited by Ajaykumar Vishwakarma, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, United States, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, Cambridge, MA, United States, Jeffrey M. Karp, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, United States, Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States, Harvard Stem Cell Institute, Broad Institute of MIT and Harvard, Cambriege, MA, United States.
| Other author | Vishwakarma, Ajaykumar. |
| Other author | Karp, Jeffrey. |
| Format | Electronic |
| Publication Info | London : Elsevier/Academic Press, [2017] |
| Description | xv, 625 pages : illustrations (chiefly color) ; 28 cm |
| Supplemental Content | Full text available from eBook - Biochemistry, Genetics and Molecular Biology 2017 [EBCBGMB17] |
| Subjects |
| Contents | I. Biology of stem cell niches and molecular mechanisms -- The need to study, mimic, and target stem cell niches -- Harnessing the biology of stem cells' niche -- Pluripotent stem cell microenvironment -- Regulation of hematopoietic stem cell dynamics by molecular niche signaling -- HSC niche: regulation of mobilization and homing -- Neuronal stem cells niches of the brain -- Cardiovascular stem cell niche -- Intestinal epithelial Lgr5+ stem cell niche and organoids -- The epithelial stem cell niche in skin -- The satellite cell niche in skeletal muscle -- The cancer stem cell niche -- Cellular senescence and stem cell niche -- Biochemical and physical cues in the stem cell niche directing cell fate -- Matrix chemistry controlling stem cell behavior -- Matrix growth factor and surface ligand presentation -- Effects of matrix mechanical forces and geometry on stem cell behavior -- Wettability effect on stem cell behavior -- Fluid flow control of stem cells with investigation of mechanotransduction pathways -- Hypoxia regulation of stem cell: mechanisms, biological properties, and applications -- III. Designing smart biomaterials to mimic and control stem cell niche -- Polymer design and development -- Design and development of ceramics and glasses -- Surface functionalization of biomaterials -- Biofunctional hydrogels for three-dimensional stem cell culture -- Technologies to engineer cell substrate mechanics in hydrogels -- Micro- and nanosurface patterning technologies -- Self-assembled nanostructures (SANs) -- Biometric nanofibers as artificial stem cell niche -- IV. Bioengineering strategies to model synthetic stem cell niches -- Employing microfluidic devices to induce concentration gradients -- Engineering niches for embryonic and induced pluripotent stem cells -- Engineering niches for cardiovascular tissue regeneration -- Engineering niches for blood vessel regeneration -- Engineering niches for bone tissue regeneration -- Engineering vascular niche for bone tissue regeneration -- Engineering niches for cartilage tissue regeneration -- Engineering niches for stem and progenitor cell differentiation into immune cells -- Engineering niches for skin and wound healing -- Designing stem cell niche for liver development and regeneration -- Engineering the niche for intestinal regeneration. |
| Bibliography note | Includes bibliographical references and index. |
| Access restriction | Available only to authorized users. |
| Technical details | Mode of access: World Wide Web |
| Genre/form | Electronic books. |
| LCCN | 2017302976 |
| ISBN | 9780128027349 (pbk.) |
| ISBN | 0128027347 (pbk.) |
Availability
| Library | Location | Call Number | Status | Item Actions |
|---|---|---|---|---|
| Electronic Resources | Access Content Online | ✔ Available |