Nonsense mutation correction in human diseases an approach for targeted medicine / Hana Benhabiles, Jieshuang Jia, Fabrice Lejeune.
| Author/creator | Benhabiles, Hana |
| Other author | Jia, Jieshuang. |
| Other author | Lejeune, Fabrice. |
| Format | Electronic |
| Publication Info | Amsterdam ; Boston : Academic Press is an imprint of Elsevier, [2016] |
| Description | ix, 180 pages : color illustrations ; 23 cm |
| Supplemental Content | Full text available from eBook - Biochemistry, Genetics and Molecular Biology 2016 [EBCBGMB16] |
| Subjects |
| Abstract | Nonsense Mutation Correction in Human Diseases: An Approach for Targeted Medicine provides an introduction on genetic diseases, discusses the prevalence of nonsense mutations, the consequences of a nonsense mutation for the expression of the mutant gene, and the presentation of the nonsense-mediated mRNA decay (NMD). It presents the mechanism of action and rationale associated with each strategy to correct nonsense mutations with the results of clinical trials to further support this basis. In addition, the book shows how it may be possible to combine several of these strategies to ultimately improve the efficiency of correction, also suggesting the future goals and objectives to improve treatment modalities in this evolving sphere of personalized medicine. |
| Bibliography note | Includes bibliographical references and index. |
| Access restriction | Available only to authorized users. |
| Technical details | Mode of access: World Wide Web |
| Genre/form | Electronic books. |
| LCCN | 2015957908 |
| ISBN | 9780128044681 (pbk.) |
| ISBN | 0128044683 (pbk.) |
| ISBN | (PDF ebook) |
Availability
| Library | Location | Call Number | Status | Item Actions |
|---|---|---|---|---|
| Electronic Resources | Access Content Online | ✔ Available |