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003 OCoLC;

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035 a| (Sirsi) o1164146371;

035 a| (OCoLC)1164146371;

049 a| EREE;

090 a| QL638.C94;

100 1 a| Wu, Xinjun,e| author.?| UNAUTHORIZED;

245 10 a| Characterization of Pgrmcs and mPRs in oocyte maturation and ovulation in zebrafish (Danio rerio) /c| by Xinjun Wu.;

264 1 a| [Greenville, N.C.] :b| [East Carolina University],c| 2020.;

300 a| 154 pages :b| illustrations (chiefly color);

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

347 a| text fileb| PDFc| 34.91 MB2| rda;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| Interdisciplinary Biological Sciencec| East Carolina Universityd| 2020.;

500 a| Presented to the faculty of the Interdisciplinary Doctoral Program in Biological Sciences.;

500 a| Advisor: Yong Zhu;

500 a| Title from PDF t.p. (viewed March 17, 2021).;

520 3 a| It is well known that progestins initiate important reproductive processes such as oocyte maturation and ovulation in vertebrates. Progestins exert functions through binding to progestin receptors. At least three families of progestin receptors including nuclear progestin receptor (Pgr), progestin receptor membrane components (Pgrmcs), and membrane progestin receptors (mPRs) may mediate these actions of progestins. However, knockout studies of these purported progestin receptors in oocyte maturation and ovulation are still rare. The main objective of this study is to determine in vivo functions of these purported progestin receptors, especially in oocyte maturation and ovulation via individual and combined knockouts of these progestin receptors. We found involvements of Pgr, Pgrmcs, and mPRs in oocyte maturation and oocyte ovulation in zebrafish.;

504 a| Includes bibliographical references.;

650 0 a| Zebra daniox| Reproduction.=| ^A584582;

650 0 a| Zebra daniox| Physiology.=| ^A584582;

650 0 a| Progesteronex| Receptors.=| ^A162263;

700 1 a| Zhu, Yong,e| degree supervisor.=| ^A1041908;

710 2 a| East Carolina University.b| Interdisciplinary Doctoral Program in Biological Sciences.?| UNAUTHORIZED;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/8606;

949 o| wjh;

994 a| C0b| ERE;

596 a| 1 4;

998 a| 5336236;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 5336236-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 7/9/2020x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 5336236-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 7/9/2020x| ETDz| HERESOURCE;

Characterization of Pgrmcs and mPRs in oocyte maturation and ovulation in zebrafish (Danio rerio) / by Xinjun Wu.

Author/creator	Wu, Xinjun author.
Other author	Zhu, Yong, degree supervisor.
Other author	East Carolina University. Interdisciplinary Doctoral Program in Biological Sciences.
Format	Theses and dissertations
Publication	[Greenville, N.C.] : [East Carolina University], 2020.
Description	154 pages : illustrations (chiefly color)
Supplemental Content	Access via ScholarShip
Subjects	Zebra danio--Reproduction. Zebra danio--Physiology. Progesterone--Receptors.

Summary	It is well known that progestins initiate important reproductive processes such as oocyte maturation and ovulation in vertebrates. Progestins exert functions through binding to progestin receptors. At least three families of progestin receptors including nuclear progestin receptor (Pgr), progestin receptor membrane components (Pgrmcs), and membrane progestin receptors (mPRs) may mediate these actions of progestins. However, knockout studies of these purported progestin receptors in oocyte maturation and ovulation are still rare. The main objective of this study is to determine in vivo functions of these purported progestin receptors, especially in oocyte maturation and ovulation via individual and combined knockouts of these progestin receptors. We found involvements of Pgr, Pgrmcs, and mPRs in oocyte maturation and oocyte ovulation in zebrafish.
General note	Presented to the faculty of the Interdisciplinary Doctoral Program in Biological Sciences.
General note	Advisor: Yong Zhu
General note	Title from PDF t.p. (viewed March 17, 2021).
Dissertation note	Interdisciplinary Biological Science East Carolina University 2020.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

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Characterization of Pgrmcs and mPRs in oocyte maturation and ovulation in zebrafish (Danio rerio) / by Xinjun Wu.

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