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035 a| (Sirsi) o1230261684;

035 a| (OCoLC)1230261684;

049 a| EREE;

090 a| QM565;

100 1 a| Huda, Fatma Tahsin,e| author.?| UNAUTHORIZED;

245 10 a| Influence of perivascular adipose tissue on central arterial mechanics and hemodynamics :b| a parametric fluid structure interaction analysis /c| by Fatama Tahsin Huda.;

264 1 a| [Greenville, N.C.] :b| [East Carolina University],c| 2020.;

300 a| 67 pages :b| illustrations (some color);

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

347 a| text fileb| PDFc| 12.90 MB2| rda;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| Biomedical Engineeringc| East Carolina Universityd| 2020.;

500 a| Presented to the faculty of the Department of Engineering.;

500 a| Advisor: Ali Vahdati;

500 a| Title from PDF t.p. (viewed April 8, 2021).;

520 3 a| This study aims to evaluate the biomechanical influence of perivascular adipose tissue (PVAT) on arterial wall mechanics and hemodynamics, which are key regulators in cardiovascular disease progression. Fluid-structure interaction (FSI) models of blood flow in three idealized central arteries surrounded by PVAT of different mechanical properties and thicknesses were solved using the open-source finite element software, FEBio. For FSI analysis, normal, aged, and fibulin-5 deficient (early aging symptoms) suprarenal abdominal aorta (SAA), infrarenal abdominal aorta (IAA), and common carotid artery (CCA) of mice are used as model vessels. Different in-vivo configurations of blood vessels, such as pulsatile flow, non-Newtonian blood flow characteristics, and anisotropic properties of the arterial wall, are included for realistic outcomes. The results of the computational model show that the mechanical properties of adipose tissue significantly influence maximum tensile stress, wall shear stress, and arterial expansion. The comparison between simulation results shows that the maximum tensile stress on the arterial wall and expansion of the artery in response to hemodynamic load decreases with an increasing modulus of PVAT. In contrast, the wall shear stress of the artery increases with an increasing modulus of PVAT. The results of the effect of varying of PVAT thickness show a minor influence on the arterial wall expansion and wall shear stress. While these FEM models were designed for parametric analysis of PVAT influence on vessel mechanics, they were also used to evaluate the difference in arterial expansion for Newtonian and non-Newtonian blood flow characteristics. The findings of this study highlight the importance of including adipose tissue in evaluating arterial wall mechanics and hemodynamic parameters in cardiovascular disease research.;

504 a| Includes bibliographical references.;

650 0 a| Adipose tissues.=| ^A76060;

650 0 a| Hemodynamics.=| ^A1786;

650 0 a| Heartx| Diseases.=| ^A453321;

700 1 a| Vadati, Alex,e| degree supervisor.=| ^A1486373;

710 2 a| East Carolina University.b| Department of Engineering.=| ^A1231592;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/8768;

949 o| wjh;

994 a| C0b| ERE;

596 a| 1 4;

998 a| 5545013;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 5545013-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 1/12/2021x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 5545013-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 1/12/2021x| ETDz| HERESOURCE;

Influence of perivascular adipose tissue on central arterial mechanics and hemodynamics : a parametric fluid structure interaction analysis / by Fatama Tahsin Huda.

Author/creator	Huda, Fatma Tahsin author.
Other author	Vadati, Alex, degree supervisor.
Other author	East Carolina University. Department of Engineering.
Format	Theses and dissertations
Publication	[Greenville, N.C.] : [East Carolina University], 2020.
Description	67 pages : illustrations (some color)
Supplemental Content	Access via ScholarShip
Subjects	Adipose tissues. Hemodynamics. Heart--Diseases.

Summary	This study aims to evaluate the biomechanical influence of perivascular adipose tissue (PVAT) on arterial wall mechanics and hemodynamics, which are key regulators in cardiovascular disease progression. Fluid-structure interaction (FSI) models of blood flow in three idealized central arteries surrounded by PVAT of different mechanical properties and thicknesses were solved using the open-source finite element software, FEBio. For FSI analysis, normal, aged, and fibulin-5 deficient (early aging symptoms) suprarenal abdominal aorta (SAA), infrarenal abdominal aorta (IAA), and common carotid artery (CCA) of mice are used as model vessels. Different in-vivo configurations of blood vessels, such as pulsatile flow, non-Newtonian blood flow characteristics, and anisotropic properties of the arterial wall, are included for realistic outcomes. The results of the computational model show that the mechanical properties of adipose tissue significantly influence maximum tensile stress, wall shear stress, and arterial expansion. The comparison between simulation results shows that the maximum tensile stress on the arterial wall and expansion of the artery in response to hemodynamic load decreases with an increasing modulus of PVAT. In contrast, the wall shear stress of the artery increases with an increasing modulus of PVAT. The results of the effect of varying of PVAT thickness show a minor influence on the arterial wall expansion and wall shear stress. While these FEM models were designed for parametric analysis of PVAT influence on vessel mechanics, they were also used to evaluate the difference in arterial expansion for Newtonian and non-Newtonian blood flow characteristics. The findings of this study highlight the importance of including adipose tissue in evaluating arterial wall mechanics and hemodynamic parameters in cardiovascular disease research.
General note	Presented to the faculty of the Department of Engineering.
General note	Advisor: Ali Vahdati
General note	Title from PDF t.p. (viewed April 8, 2021).
Dissertation note	Biomedical Engineering East Carolina University 2020.
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

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Influence of perivascular adipose tissue on central arterial mechanics and hemodynamics : a parametric fluid structure interaction analysis / by Fatama Tahsin Huda.

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