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010 a| 2013042727;

020 a| 9781118487686 (cloth);

020 a| 1118487680 (cloth);

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245 02 a| A handbook for DNA-encoded chemistryh| [electronic resource] :b| theory and applications for exploring chemical space and drug discovery /c| edited by Robert A. Goodnow, Jr.;

260 a| Hoboken, New Jersey :b| John Wiley & Sons, Inc.,c| [2014];

300 a| xxv, 453 pages, 16 unnumbered pages of plates :b| illustrations (some color) ;c| 25 cm;

504 a| Includes bibliographical references and index.;

505 0 a| Just enough knowledge? -- A brief history of the development of combinatorial chemistry and the emerging need for DNA-encoded chemistry -- A history of DNA-encoding -- DNA-compatible chemistry -- Foundations of a DNA-encoded library (DEL) -- Practices for synthesizing DNA-encoded libraries -- Chemical gene design for DNA-encoded libraries -- Analytical challenges for DNA-encoded library systems -- Information technology: functionality and architectures for DNA-encoding -- Theoretical considerations of the application of DNA-encoded libraries to drug discovery -- Begin with the end in mind : the hit-to-lead process -- Enumeration and visualization of large combinatorial chemical libraries -- Screening large compound collections -- Reported applications of DNA-encoded library chemistry -- Dual-pharmacophore DNA-encoded chemical libraries -- Hit identification and hit follow-up -- Using DNA to program chemical synthesis, discover new reactions, and detect ligand binding -- An outlook and the changing feasibility and economics of chemical diversity exploration with DNA-encoded combinatorial approaches -- Keeping the promise? an outlook on dna chemical library technology.;

506 a| Available only to authorized users.;

538 a| Mode of access: World Wide Web;

650 12 a| Combinatorial Chemistry Techniquesx| methods.=| ^A1205039;

650 22 a| DNAx| chemical synthesis.=| ^A920250;

650 22 a| Drug Discoveryx| methods.=| ^A1023263;

650 22 a| Gene Library.=| ^A926339;

650 22 a| Small Molecule Librariesx| chemical synthesis.=| ^A1205478;

655 0 a| Electronic books.=| ^A491897;

700 1 a| Goodnow, Robert A.,c| Jr.?| UNAUTHORIZED;

856 40 z| Full text available from Ebook Central - Academic Completeu| https://ebookcentral.proquest.com/lib/eastcarolina/detail.action?docID=1662195;

949 a| CLICK ON WEB ADDRESSw| ASISh| JOYNER188;

949 a| CLICK ON WEB ADDRESSw| ASISh| HSL77;

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999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 5574308-1001l| JNETm| JOYNERr| Ys| Yt| JNESSBKu| 3/16/2021x| EBOOKz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 5574308-2001l| HSLELECm| HSLr| Ys| Yt| HEBKu| 3/16/2021x| EBOOKz| HERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 5574308-3001l| MNETm| JMUSICr| Ys| Yt| MNESSBKu| 3/16/2021x| EBOOKz| JERESOURCE;

A handbook for DNA-encoded chemistry theory and applications for exploring chemical space and drug discovery / edited by Robert A. Goodnow, Jr.

Other author	Goodnow, Robert A., Jr.
Format	Electronic
Publication Info	Hoboken, New Jersey : John Wiley & Sons, Inc., [2014]
Description	xxv, 453 pages, 16 unnumbered pages of plates : illustrations (some color) ; 25 cm
Supplemental Content	Full text available from Ebook Central - Academic Complete
Subjects	Combinatorial Chemistry Techniques--methods. DNA--chemical synthesis. Drug Discovery--methods. Gene Library. Small Molecule Libraries--chemical synthesis.

Contents	Just enough knowledge? -- A brief history of the development of combinatorial chemistry and the emerging need for DNA-encoded chemistry -- A history of DNA-encoding -- DNA-compatible chemistry -- Foundations of a DNA-encoded library (DEL) -- Practices for synthesizing DNA-encoded libraries -- Chemical gene design for DNA-encoded libraries -- Analytical challenges for DNA-encoded library systems -- Information technology: functionality and architectures for DNA-encoding -- Theoretical considerations of the application of DNA-encoded libraries to drug discovery -- Begin with the end in mind : the hit-to-lead process -- Enumeration and visualization of large combinatorial chemical libraries -- Screening large compound collections -- Reported applications of DNA-encoded library chemistry -- Dual-pharmacophore DNA-encoded chemical libraries -- Hit identification and hit follow-up -- Using DNA to program chemical synthesis, discover new reactions, and detect ligand binding -- An outlook and the changing feasibility and economics of chemical diversity exploration with DNA-encoded combinatorial approaches -- Keeping the promise? an outlook on dna chemical library technology.
Bibliography note	Includes bibliographical references and index.
Access restriction	Available only to authorized users.
Technical details	Mode of access: World Wide Web
Genre/form	Electronic books.
LCCN	2013042727
ISBN	9781118487686 (cloth)
ISBN	1118487680 (cloth)

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A handbook for DNA-encoded chemistry theory and applications for exploring chemical space and drug discovery / edited by Robert A. Goodnow, Jr.

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