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111 2 a| Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine (Workshop)d| (2017 :c| Washington, D.C.)?| UNAUTHORIZED;

245 10 a| Advancing disease modeling in animal-based research in support of precision medicineh| [electronic resource] :b| proceedings of a workshop /c| Erin Hammers Forstag and Lida Anestidou, rapporteurs ; Roundtable on Science and Welfare in Laboratory Animal Use, Institute for Laboratory Animal Research, Division of Earth and Life Studies, the National Academies of Sciences, Engineering, Medicine.;

260 a| Washington, DC :b| The National Academies Press,c| [2018];

300 a| xiii, 123 pages :b| color illustrations ;c| 23 cm;

504 a| Includes bibliographical references (pages 90-94).;

505 0 a| Introduction to precision medicine and animal models -- Existing precision medicine initiatives -- The promise and perils of animal models -- Reproducibility and predictivity -- In vitro alternatives to animal models -- Assessing safety and toxicology -- Patient perspectives -- Reflections on the workshop -- References.;

506 a| Available only to authorized users.;

520 a| "Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed to focus on the development, implementation, and interpretation of model organisms to advance and accelerate the field of precision medicine. Participants examined the extent to which next-generation animal models, designed using patient data and phenotyping platforms targeted to reveal and inform disease mechanisms, will be essential to the successful implementation of precision medicine. This publication summarizes the presentations and discussions from the workshop"--Publisher's description.;

530 a| Also issued online.;

538 a| Mode of access: World Wide Web;

650 0 a| Animal models in researchv| Congresses.=| ^A146732;

650 0 a| Precision medicinev| Congresses.=| ^A1173559;

650 12 a| Disease Models, Animal.=| ^A918974;

650 22 a| Precision Medicinex| methods.=| ^A1037554;

650 7 a| Animal models in research.2| fast0| (OCoLC)fst00809302;

650 7 a| Personalized medicine.2| fast0| (OCoLC)fst01910010;

655 0 a| Electronic books.=| ^A491897;

700 1 a| Forstag, Erin Hammers.=| ^A1333318;

700 1 a| Anestidou, Lida,d| 1965-=| ^A1334369;

710 2 a| Institute for Laboratory Animal Research (U.S.).b| Roundtable on Science and Welfare in Laboratory Animal Use.=| ^A1334397;

710 2 a| National Academies of Sciences, Engineering, and Medicine (U.S.).b| Division on Earth and Life Studies.=| ^A1352538;

856 40 z| Full text available from Ebook Central - Academic Completeu| https://ebookcentral.proquest.com/lib/eastcarolina/detail.action?docID=5406370;

947 a| (OCoLC)on1042161471;

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Advancing disease modeling in animal-based research in support of precision medicine proceedings of a workshop / Erin Hammers Forstag and Lida Anestidou, rapporteurs ; Roundtable on Science and Welfare in Laboratory Animal Use, Institute for Laboratory Animal Research, Division of Earth and Life Studies, the National Academies of Sciences, Engineering, Medicine.

Author/creator	Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine (Workshop)
Format	Electronic
Publication Info	Washington, DC : The National Academies Press, [2018]
Description	xiii, 123 pages : color illustrations ; 23 cm
Supplemental Content	Full text available from Ebook Central - Academic Complete
Subjects	Animal models in research--Congresses. Precision medicine--Congresses. Disease Models, Animal. Precision Medicine--methods.

Other author/creator	Forstag, Erin Hammers.
Other author/creator	Anestidou, Lida, 1965-
Other author/creator	Institute for Laboratory Animal Research (U.S.). Roundtable on Science and Welfare in Laboratory Animal Use.
Other author/creator	National Academies of Sciences, Engineering, and Medicine (U.S.). Division on Earth and Life Studies.
Contents	Introduction to precision medicine and animal models -- Existing precision medicine initiatives -- The promise and perils of animal models -- Reproducibility and predictivity -- In vitro alternatives to animal models -- Assessing safety and toxicology -- Patient perspectives -- Reflections on the workshop -- References.
Abstract	"Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed to focus on the development, implementation, and interpretation of model organisms to advance and accelerate the field of precision medicine. Participants examined the extent to which next-generation animal models, designed using patient data and phenotyping platforms targeted to reveal and inform disease mechanisms, will be essential to the successful implementation of precision medicine. This publication summarizes the presentations and discussions from the workshop"--Publisher's description.
Bibliography note	Includes bibliographical references (pages 90-94).
Access restriction	Available only to authorized users.
Other forms	Also issued online.
Technical details	Mode of access: World Wide Web
Genre/form	Electronic books.
LCCN	2018302947
ISBN	9780309471169 (paperback)
ISBN	0309471168 (paperback)

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