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020 a| 9781118836309 (epub);

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245 00 a| Cyclic-nucleotide phosphodiesterases in the central nervous systemh| [electronic resource] :b| from biology to drug discovery /c| edited by Nicholas J. Brandon, Anthony R. West.;

260 a| Hoboken, New Jersey :b| John Wiley & Sons, Inc.,c| [2014];

300 a| 1 online resource.;

504 a| Includes bibliographical references.;

505 0 a| Phosphodiesterases and cyclic nucleotide signaling in the CNS / Marco Conti and Wito Richter -- Putting together the pieces of phosphodiesterase distribution patterns in the brain : a jigsaw puzzle of cyclic nucleotide regulation / Michy P. Kelly -- Compartmentalization and regulation of cyclic nucleotide signalling in the CNS / Manuela Zaccolo and Alessandra Stangherlin -- Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brain / Frank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup -- Recent results in phosphodiesterase inhibitor development and CNS applications / David P. Rotella -- Crystal structures of phosphodiesterases and implication on discovery of inhibitors / Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang -- Inhibition of cyclic nucleotide phosphodiesterases to regulate memory / Han-Ting Zhang, Ying Xu, James O'Donnell -- Emerging role for PDE4 in neuropsychiatric disorders : translating advances from genetic studies into relevant therapeutic strategies / Sandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa -- Beyond erectile dysfunction : understanding PDE5 activity in the central nervous system / Eva P. P. Bollen, Kris Rutten, Olga A. H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts -- Molecular and cellular understanding of PDE10A : a dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia function / Erik I. Charych and Nicholas J. Brandon -- Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neurons / Sarah Threlfell and Anthony R. West -- The role of phosphodiesterases in dopamine systems governing motivated behavior / Gretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick -- Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injury / Elena Nikulina and Marie T. Filbin.;

506 a| Available only to authorized users.;

538 a| Mode of access: World Wide Web;

588 a| Description based on print version record and CIP data provided by publisher.;

650 12 a| 3',5'-Cyclic-AMP Phosphodiesterasesx| metabolism.?| UNAUTHORIZED;

650 12 a| 3',5'-Cyclic-AMP Phosphodiesterasesx| therapeutic use.?| UNAUTHORIZED;

650 22 a| Central Nervous Systemx| physiology.=| ^A921305;

650 22 a| Central Nervous System Diseasesx| drug therapy.=| ^A920539;

650 22 a| Drug Discovery.=| ^A1013013;

655 0 a| Electronic books.=| ^A491897;

700 1 a| Brandon, Nicholas J.?| UNAUTHORIZED;

700 1 a| West, Anthony R.,d| 1970-?| UNAUTHORIZED;

776 08 i| Print version:t| Cyclic-nucleotide phosphodiesterases in the central nervous systemd| Hoboken, New Jersey : John Wiley & Sons, Inc., [2014]z| 9780470566688w| (DLC) 2013042742;

856 40 z| Full text available from Ebook Central - Academic Completeu| https://ebookcentral.proquest.com/lib/eastcarolina/detail.action?docID=1650866;

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Cyclic-nucleotide phosphodiesterases in the central nervous system from biology to drug discovery / edited by Nicholas J. Brandon, Anthony R. West.

Other author	Brandon, Nicholas J.
Other author	West, Anthony R., 1970-
Format	Electronic
Publication Info	Hoboken, New Jersey : John Wiley & Sons, Inc., [2014]
Description	1 online resource.
Supplemental Content	Full text available from Ebook Central - Academic Complete
Subjects	3',5'-Cyclic-AMP Phosphodiesterases--metabolism. 3',5'-Cyclic-AMP Phosphodiesterases--therapeutic use. Central Nervous System--physiology. Central Nervous System Diseases--drug therapy. Drug Discovery.

Contents	Phosphodiesterases and cyclic nucleotide signaling in the CNS / Marco Conti and Wito Richter -- Putting together the pieces of phosphodiesterase distribution patterns in the brain : a jigsaw puzzle of cyclic nucleotide regulation / Michy P. Kelly -- Compartmentalization and regulation of cyclic nucleotide signalling in the CNS / Manuela Zaccolo and Alessandra Stangherlin -- Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brain / Frank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup -- Recent results in phosphodiesterase inhibitor development and CNS applications / David P. Rotella -- Crystal structures of phosphodiesterases and implication on discovery of inhibitors / Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang -- Inhibition of cyclic nucleotide phosphodiesterases to regulate memory / Han-Ting Zhang, Ying Xu, James O'Donnell -- Emerging role for PDE4 in neuropsychiatric disorders : translating advances from genetic studies into relevant therapeutic strategies / Sandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa -- Beyond erectile dysfunction : understanding PDE5 activity in the central nervous system / Eva P. P. Bollen, Kris Rutten, Olga A. H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts -- Molecular and cellular understanding of PDE10A : a dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia function / Erik I. Charych and Nicholas J. Brandon -- Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neurons / Sarah Threlfell and Anthony R. West -- The role of phosphodiesterases in dopamine systems governing motivated behavior / Gretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick -- Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injury / Elena Nikulina and Marie T. Filbin.
Bibliography note	Includes bibliographical references.
Access restriction	Available only to authorized users.
Technical details	Mode of access: World Wide Web
Source of description	Description based on print version record and CIP data provided by publisher.
Issued in other form	Print version: Cyclic-nucleotide phosphodiesterases in the central nervous system Hoboken, New Jersey : John Wiley & Sons, Inc., [2014] 9780470566688
Genre/form	Electronic books.
LCCN	2013043100
ISBN	9781118836323 (pdf)
ISBN	9781118836309 (epub)
ISBN	9781118836538 ( mobi)

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Cyclic-nucleotide phosphodiesterases in the central nervous system from biology to drug discovery / edited by Nicholas J. Brandon, Anthony R. West.

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