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010 a| 2011044253;

020 a| 9780470878279 (cloth);

020 a| 0470878274 (cloth);

020 z| 9781118274408 (ebk.);

020 z| 1118274407 (ebk.);

035 a| (WaSeSS)ssj0000677315;

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050 00 a| RM301.25b| .D78615 2012;

060 10 a| QV 55;

082 00 a| 338.4/761512| 23;

245 00 a| Drug repositioningh| [electronic resource] :b| bringing new life to shelved assets and existing drugs /c| edited by Michael J. Barratt, Donald Frail.;

260 a| Hoboken, N. J. :b| John Wiley & Sons,;

300 a| xx, 477 p. :b| ill. ;c| 24 cm.;

504 a| Includes bibliographical references and index.;

505 0 a| Drug repositioning : the business case and current strategies to repurpose shelved candidates and marketed drugs / John Arrowsmith and Richard Harrison -- Opportunities and challenges associated with developing additional indications for clinical development candidates and marketed drugs / Donald Frail and Michael Barratt -- Clinical and operational considerations in repositioning marketed drugs and drug candidates / Damian O'Connell, David Sequeira, and Maria Miller -- Regulatory considerations and strategies for drug repositioning / Ken Phelps -- Computational and bioinformatic strategies for drug repositioning / Richard Mazzarella and Craig Webb -- Mining scientific and clinical databases to identify novel uses for existing drugs / Christos Andronis ... [et al.] -- Predicting the polypharmacology of drugs : identifying new uses through chemoinformatics, structural informatics and molecular modeling based approaches / Li Xie ... [et al.] -- Systematic phenotypic screening for novel synergistic combinations: a new paradigm for repositioning existing drugs / Margaret Lee -- Phenotypic in vivo screening to identify new, unpredicted indications for existing drugs and drug candidates / Michael Saporito, Christopher Lipinski, and Andrew Reaume -- Old drugs yield new discoveries : examples from the prodrug, chiral switch and site-selective deuteration strategies / Adam Morgan ... [et al.] -- Repurposing drugs for tropical diseases : case studies and open-source screening initiatives / Curtis Chong -- Drug repositioning efforts by non-profit foundations -- Business development strategies in the repositioning industry / Aris Persidis and Elizabeth Stark -- A case study in drug repositioning : Sosei / Akinori Mochizuki and Makiko Aoyama.;

506 a| Available only to authorized users.;

538 a| Mode of access: World Wide Web;

650 0 a| Drug development.=| ^A443888;

650 12 a| Drug Repositioning.=| ^A1337671;

650 22 a| Computational Biologyx| methods.=| ^A932025;

650 22 a| Drug Industryx| economics.=| ^A1004813;

650 22 a| Pharmaceutical Preparationsx| economics.=| ^A948134;

655 0 a| Electronic books.=| ^A491897;

700 1 a| Barratt, Michael J.?| UNAUTHORIZED;

700 1 a| Frail, Donald.?| UNAUTHORIZED;

856 40 z| Full text available from Ebook Central - Academic Completeu| https://ebookcentral.proquest.com/lib/eastcarolina/detail.action?docID=938848;

949 a| CLICK ON WEB ADDRESSw| ASISh| JOYNER188;

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999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 5593442-3001l| MNETm| JMUSICr| Ys| Yt| MNESSBKu| 4/16/2021x| EBOOKz| JERESOURCE;

Drug repositioning bringing new life to shelved assets and existing drugs / edited by Michael J. Barratt, Donald Frail.

Other author	Barratt, Michael J.
Other author	Frail, Donald.
Format	Electronic
Publication Info	Hoboken, N. J. : John Wiley & Sons,
Description	xx, 477 p. : ill. ; 24 cm.
Supplemental Content	Full text available from Ebook Central - Academic Complete
Subjects	Drug development. Drug development. Drug Repositioning. Computational Biology--methods. Drug Industry--economics. Pharmaceutical Preparations--economics.

Contents	Drug repositioning : the business case and current strategies to repurpose shelved candidates and marketed drugs / John Arrowsmith and Richard Harrison -- Opportunities and challenges associated with developing additional indications for clinical development candidates and marketed drugs / Donald Frail and Michael Barratt -- Clinical and operational considerations in repositioning marketed drugs and drug candidates / Damian O'Connell, David Sequeira, and Maria Miller -- Regulatory considerations and strategies for drug repositioning / Ken Phelps -- Computational and bioinformatic strategies for drug repositioning / Richard Mazzarella and Craig Webb -- Mining scientific and clinical databases to identify novel uses for existing drugs / Christos Andronis ... [et al.] -- Predicting the polypharmacology of drugs : identifying new uses through chemoinformatics, structural informatics and molecular modeling based approaches / Li Xie ... [et al.] -- Systematic phenotypic screening for novel synergistic combinations: a new paradigm for repositioning existing drugs / Margaret Lee -- Phenotypic in vivo screening to identify new, unpredicted indications for existing drugs and drug candidates / Michael Saporito, Christopher Lipinski, and Andrew Reaume -- Old drugs yield new discoveries : examples from the prodrug, chiral switch and site-selective deuteration strategies / Adam Morgan ... [et al.] -- Repurposing drugs for tropical diseases : case studies and open-source screening initiatives / Curtis Chong -- Drug repositioning efforts by non-profit foundations -- Business development strategies in the repositioning industry / Aris Persidis and Elizabeth Stark -- A case study in drug repositioning : Sosei / Akinori Mochizuki and Makiko Aoyama.
Bibliography note	Includes bibliographical references and index.
Access restriction	Available only to authorized users.
Technical details	Mode of access: World Wide Web
Genre/form	Electronic books.
LCCN	2011044253
ISBN	9780470878279 (cloth)
ISBN	0470878274 (cloth)

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Drug repositioning bringing new life to shelved assets and existing drugs / edited by Michael J. Barratt, Donald Frail.

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