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074 a| 0985-A-12 (online);

086 0 a| VA 1.107/3:N 95;

100 1 a| Kansagara, Devan,e| author.=| ^A1033076;

245 10 a| Nutritional supplements for age-related macular degeneration :b| a systematic review /c| Devan Kansagara [and four others].;

264 1 a| Washington, DC :b| Department of Veterans Affairs, Veterans Health Administration, Health Services Research & Development Service,c| 2012.;

300 a| 1 online resource (iv, 43 pages) :b| illustrations;

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

500 a| "Evidence-based synthesis program.";

500 a| "January 2012.";

500 a| GPO Cataloging Record Distribution Program (CRDP).;

504 a| Includes bibliographical references (pages 29-32).;

520 3 a| Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in the developed world. In 2004, AMD affected 1.75 million persons in the United States, a number that is expected to rise to nearly 3 million by 2020 due to the aging of the population. The severity of macular degeneration ranges from Category 1 (least severe) to Category 4 (most severe), and "advanced AMD" is defined as having geographic atrophy involving the center of the macula or features of choroidal neovascularization. Observational studies suggest that people with dietary intakes higher in various carotenoids, antioxidants and omega-3 fatty acids have a lower risk of developing AMD. This has led to several supplementation trials designed to examine the ability of nutritional supplement with carotenoids, antioxidants, or omega-3 fatty acids to prevent the progression of AMD. Our report focuses on the evidence documenting the potential benefits and harms of certain dietary supplements in patients with AMD. We conducted a systematic review of published literature to address the following key questions: In patients with age-related macular degeneration, do nutritional supplements containing carotenoids, antioxidants, or omega-3 fatty acids alone or in combination prevent functional visual loss? In adult populations, what are the harms of carotenoid, antioxidant, and omega-3 fatty acid supplementation?;

536 a| Prepared for: Department of Veterans Affairs, Veterans Health Administration, Health Services Research & Development Service, Washington, DC 20420. Prepared by: Evidence-based Synthesis Program (ESP) Center, Portland VA Medical Center, Portland, OR, Devan Kansagara, MD, MCR, Director;

536 a| VA-ESPf| 05-225;

588 a| Description based on online resource; title from PDF cover (VA, viewed April 23, 2021).;

650 0 a| Retinal degenerationx| Diet therapyz| United States.=| ^A144513;

650 0 a| Dietary supplementsz| United States.=| ^A12221;

650 0 a| Outcome assessment (Medical care)z| United States.=| ^A1006293;

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650 7 a| Outcome assessment (Medical care)2| fast0| (OCoLC)fst01049109;

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655 7 a| Technical reports.2| lcgft;

710 2 a| Portland VA Medical Center.b| Evidence-based Synthesis Program Center.=| ^A1212022;

710 2 a| Evidence-based Synthesis Program (U.S.)?| UNAUTHORIZED;

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Nutritional supplements for age-related macular degeneration : a systematic review / Devan Kansagara [and four others].

Author/creator	Kansagara, Devan author.
Other author	United States. Department of Veterans Affairs. Health Services Research and Development Service, issuing body.
Other author	Portland VA Medical Center. Evidence-based Synthesis Program Center.
Other author	Evidence-based Synthesis Program (U.S.)
Format	Electronic
Publication	Washington, DC : Department of Veterans Affairs, Veterans Health Administration, Health Services Research & Development Service, 2012.
Description	1 online resource (iv, 43 pages) : illustrations
Supplemental Content	https://purl.fdlp.gov/GPO/gpo154961
Subjects	Retinal degeneration--Diet therapy. --United States. Dietary supplements--United States. Outcome assessment (Medical care)--United States.

Summary	Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in the developed world. In 2004, AMD affected 1.75 million persons in the United States, a number that is expected to rise to nearly 3 million by 2020 due to the aging of the population. The severity of macular degeneration ranges from Category 1 (least severe) to Category 4 (most severe), and "advanced AMD" is defined as having geographic atrophy involving the center of the macula or features of choroidal neovascularization. Observational studies suggest that people with dietary intakes higher in various carotenoids, antioxidants and omega-3 fatty acids have a lower risk of developing AMD. This has led to several supplementation trials designed to examine the ability of nutritional supplement with carotenoids, antioxidants, or omega-3 fatty acids to prevent the progression of AMD. Our report focuses on the evidence documenting the potential benefits and harms of certain dietary supplements in patients with AMD. We conducted a systematic review of published literature to address the following key questions: In patients with age-related macular degeneration, do nutritional supplements containing carotenoids, antioxidants, or omega-3 fatty acids alone or in combination prevent functional visual loss? In adult populations, what are the harms of carotenoid, antioxidant, and omega-3 fatty acid supplementation?
General note	"Evidence-based synthesis program."
General note	"January 2012."
General note	GPO Cataloging Record Distribution Program (CRDP).
Bibliography note	Includes bibliographical references (pages 29-32).
Funding information	Prepared for: Department of Veterans Affairs, Veterans Health Administration, Health Services Research & Development Service, Washington, DC 20420. Prepared by: Evidence-based Synthesis Program (ESP) Center, Portland VA Medical Center, Portland, OR, Devan Kansagara, MD, MCR, Director
Funding information	VA-ESP 05-225
Source of description	Description based on online resource; title from PDF cover (VA, viewed April 23, 2021).
Genre/form	Technical reports.
GPO item number	0985-A-12 (online)
Govt. docs number	VA 1.107/3:N 95

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Nutritional supplements for age-related macular degeneration : a systematic review / Devan Kansagara [and four others].

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