Fighting the opioid epidemic : the role of providers and the clinical laboratory in understanding who is vulnerable / Amitava Dasgupta.

Author/creator Dasgupta, Amitava, 1958- author.
Format Electronic
PublicationAmsterdam, Netherlands ; Cambridge, MA : Elsevier, [2020]
Description1 online resource (ix, 149 pages) : illustrations
Supplemental Content Direct link to eBook
Subjects
Opioid abuse.
Opioid Epidemic
Opioid-Related Disorders

Contents Front Cover -- Fighting the Opioid Epidemic: The Role of Providers and the Clinical Laboratory in Understanding Who is Vulnerable -- Fighting the Opioid Epidemic: The Role of Providers and the Clinical Laboratory in Understanding Who is Vulnerable -- Copyright -- Dedication -- Preface -- Contents -- 1 -- Crude Opium, Morphine, Codeine, and Heroin: Past and Present -- INTRODUCTION -- OPIUM USE: FROM ANCIENT TIME TO MODERN TIME -- OPIUM AND POPPY PLANTS: LEGAL ISSUES -- ALKALOIDS FOUND IN OPIUM -- MORPHINE -- CODEINE AND THEBAINE -- HEROIN -- Heroin Synthesis and Cutting of Heroin
Contents White versus Brown and Black Tar Heroin -- Heroin Laced with Fentanyl -- Heroin Pharmacokinetics -- Adverse Effects of Heroin -- BLOOD AND URINE LEVELS OF HEROIN AND ITS METABOLITES -- Treatment of Heroin Overdose and Heroin Withdrawal -- CONCLUSIONS -- REFERENCES -- 2 -- Prescription Opioids: An Overview -- INTRODUCTION -- HISTORY OF PAIN MANAGEMENT -- OPIOID RECEPTORS -- PRESCRIPTION OPIOIDS -- Opioid Prescription Pattern -- MORPHINE -- CODEINE -- Oxycodone -- HYDROCODONE -- HYDROMORPHONE -- OXYMORPHONE -- FENTANYL -- Fentanyl Derivatives -- METHADONE -- MEPERIDINE -- TRAMADOL -- TAPENTADOL
Contents BUPRENORPHINE -- LEVORPHANOL -- PROPOXYPHENE -- EFFECT OF SEX, AGE, ETHNICITY, AND REANAL AND HEPATIC FUNCTION ON CERTIN OPIOIDS -- OTHER OPIOIDS -- ABUSE-DETERRENT OPIOID FORMULATIONS -- Physical/Chemical Barrier Technology -- Combining an Opioid Drug with an Opioid Antagonist -- Incorporation of Aversive Ingredients -- Abuse-Deterrent Prodrug Formulation -- Novel Drug Delivery System -- COMPLIANCE WITH PRESCRIPTION OPIOID -- CONCLUSIONS -- REFERENCES -- 3 -- Opioid Abuse and Opioid Epidemic -- INTRODUCTION -- ANALGESIC LADDER PROPOSED BY THE WORLD HEALTH ORGANIZATION
Contents OTHER GUIDELINES IN PAIN MANAGEMENT -- OPIOID ABUSE AND OPIOID-RELATED FATALITIES -- WHAT CAUSED OPIOID EPIDEMIC? -- Heroin Laced With Fentanyl and Fatality -- WHICH OPIOIDS ARE MOST COMMONLY ABUSED? -- Oxycodone Abuse -- Oxymorphone Abuse -- Hydrocodone or Hydromorphone Abuse -- Morphine or Codeine Abuse -- Fentanyl Abuse -- Other Abused Opioids -- COMBINED ABUSE OF OPIOIDS, OTHER DRUGS, AND ALCOHOL: A DEADLY COMBINATION -- PRESCRIPTION MONITORING -- CONCLUSIONS -- REFERENCES -- 4 -- Genetic Factors Associated With Opioid Therapy and Opioid Addiction -- INTRODUCTION
Contents SUBSTANCE ABUSE DISORDER: ROLE OF GENE AND ENVIRONMENT -- DRUG-METABOLIZING ENZYMES -- CYP FAMILY OF ENZYMES -- Polymorphism of CYP2D6 -- Polymorphism of CYP2B6 -- Polymorphism of CYP2C9 -- Polymorphisms of Other CYP Isoenzymes -- POLYMORPHISMS OF CYP2D6 AND OPIOID THERAPY -- CYP2D6 Gene Polymorphism and Codeine Therapy -- CYP2D6 Gene Polymorphism and Tramadol Therapy -- CYP2D6 Gene Polymorphism and Therapy with Oxycodone or Hydrocodone -- Methadone toxicity and pharmacogenetics issues -- Morphine and pharmacogenetic considerations -- Hydromorphone and pharmacogenomics
Contents Pharmacogenomics issues with fentanyl
Bibliography noteIncludes bibliographical references and index.
Source of descriptionDescription based on online resource; title from digital title page (viewed on August 10, 2020).
Issued in other formPrint version: Dasgupta, Amitava Fighting the Opioid Epidemic : The Role of Providers and the Clinical Laboratory in Understanding Who Is Vulnerable San Diego : Elsevier,c2020 9780128200759
ISBN9780128223901 (electronic bk.)
ISBN0128223901 (electronic bk.)

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