Novel therapeutic approaches for gastrointestinal malignancies / Ganji Purnachandra Nagaraju, Sujatha Peela, editors.
| Other author | Nagaraju, Ganji Purnachandra editor. |
| Other author | Peela, Sujatha, editor. |
| Format | Electronic |
| Publication | Singapore : Springer, 2020. |
| Description | 1 online resource (xii, 259 pages) : illustrations (some color). |
| Supplemental Content | Direct link to eBook |
| Subjects |
| Series | Diagnostics and Therapeutic Advances in GI Malignancies, 2662-2688 Diagnostics and therapeutic advances in GI malignancies. ^A1421016 |
| Contents | Intro -- Preface -- Contents -- About the Editors -- Chapter 1: Targeting Pathways in GI Malignancies -- 1.1 Introduction -- 1.2 Important Targeting Pathways in Esophageal Cancer -- 1.2.1 MAPK Signaling Pathway -- 1.2.2 PI3K/Akt Pathway -- 1.3 Important Targeting Pathways in Gastric Cancer -- 1.3.1 EGFR and HER2 Signaling Pathway -- 1.3.2 The VEGF Pathway -- 1.3.3 The PI3K/AKT/MTOR Pathway -- 1.3.4 The HGF/MET Pathway -- 1.3.5 The RhoA Signaling Pathway -- 1.3.6 The JAK/STAT Pathway -- 1.4 Important Targeting Pathways in CRC -- 1.4.1 EGFR/MAPK Signaling Pathway -- 1.4.2 Notch Pathway |
| Contents | 2.3.4 Pancreatic Cancer (PC) -- 2.4 Combining Immunotherapy with Precision Medicine -- 2.5 Conclusions -- References -- Chapter 3: Adiponectin in Gastrointestinal Malignancies -- 3.1 Introduction -- 3.2 Adiponectin and Adiponectin Receptors -- 3.3 Connection Between Obesity and Gastrointestinal Malignancies -- 3.4 Adiponectin and Obesity-Related Gastrointestinal Malignancies -- 3.4.1 Adiponectin and Gastric Cancer -- 3.4.2 Adiponectin and Colorectal Cancer -- 3.5 Conclusions and Adiponectin as a Therapeutic Agent -- References |
| Contents | Chapter 4: Small Molecule-Targeted Therapies for GI Cancers: Success and Failures -- 4.1 Introduction -- 4.2 Targeted Therapies -- 4.2.1 Immunotherapy -- 4.2.2 Small Molecule-Based Targeted Therapeutics -- 4.2.2.1 Protein Kinase Inhibitors -- 4.2.2.2 Proteasome Inhibitors -- 4.2.2.3 Matrix Metalloproteinase Inhibitors -- 4.3 Limitations of Small Molecule Inhibitor Targeted Therapies -- 4.4 Conclusion -- References -- Chapter 5: Epigenetic Biomarkers for the Detection of Gastrointestinal Cancers -- 5.1 Introduction -- 5.2 Colorectal Carcinoma and Gastric Adenocarcinoma |
| Contents | 5.3 Epigenetic Alterations and Its Relevance to Cancer -- 5.4 Major Epigenetic Modifications: Significances and Consequences (Fig. 5.2) -- 5.4.1 Epigenetic Modification Involving Methylation of DNA -- 5.4.1.1 Methylation Status of DNA as a Reliable Marker for Colorectal Cancers (CRC) -- 5.4.1.2 Methylation Status of DNA as a Reliable Marker for Gastric Cancers (GC) -- 5.4.2 Histone Modification as an Epigenetic Alteration -- 5.4.2.1 Histone Acetylation -- 5.4.2.2 Histone Methylation -- 5.4.2.3 Histone Phosphorylation -- 5.4.2.4 Histone Modification Based Biomarkers for Colorectal Cancers |
| Abstract | This book provides an up-to-date overview of gastrointestinal malignancies, including prevention, early detection, intervention, and life-extending therapeutics. It also assesses various biomarkers used for diagnostics, prognostics and prediction of response to chemoresistance. Further, it discusses the latest trends in the use of small-molecule targeted therapies and immunotherapies as single agents or combination with other treatments. Since resistance to radiation and chemotherapy contribute to the high recurrence and poor survival rates, improving the outcome for GI malignancies is dependent on the introduction of new biomarkers and therapeutic agents. Lastly, the book systematically investigates novel theranostics approaches using nanotechnology for the detection, diagnosis, and personalized treatment of GI malignancies. |
| Bibliography note | Includes bibliographical references. |
| Source of description | Online resource; title from PDF title page (SpringerLink, viewed November 30, 2020). |
| Issued in other form | Print version: 9811554706 9789811554704 |
| Genre/form | Electronic books. |
| ISBN | 9789811554711 (electronic bk.) |
| ISBN | 9811554714 (electronic bk.) |
| Standard identifier# | 10.1007/978-981-15-5471-1. |
Availability
| Library | Location | Call Number | Status | Item Actions |
|---|---|---|---|---|
| Electronic Resources | Access Content Online | ✔ Available |