SARS-CoV-2 Spike Protein Convergent Evolution : impact of virus variants on efficacy of COVID-19 therapeutics and vaccines / Daniele Focosi.
| Author/creator | Focosi, Daniele, 1980- |
| Format | Book |
| Publication Info | Cham : Springer Nature, 2021. |
| Description | online resource |
| Supplemental Content | Connect to this resource online |
| Subjects |
| Contents | Chapter 1. Why the Spike protein is relevant for COVID19 therapeutics -- Chapter 2. SARS-CoV-2 variants -- Chapter 3. Conclusion. |
| Abstract | This book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future. |
| Reproduction note | eBook. King of Prussia, PA: Rittenhouse Book Distributors, Inc, 2021 |
| Technical details | Mode of Access: World Wide Web |
| ISBN | 3030873234 |
| ISBN | 9783030873233 |
| ISBN | 9783030873240 |
| Stock number | Rittenhouse Book Distributors, Inc |
Availability
| Library | Location | Call Number | Status | Item Actions |
|---|---|---|---|---|
| Electronic Resources | Access Content Online | ✔ Available |