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020 a| 9781118681015q| (hardback);

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245 00 a| Structural biology in drug discoveryh| [electronic resource] :b| methods, techniques, and practices /c| edited by Jean-Paul Renaud.;

250 a| First edition.;

260 a| Hoboken, NJ :b| Wiley,c| 2020.;

300 a| xxviii, 660 pages ;c| 29 cm;

504 a| Includes bibliographical references and index.;

506 a| Available only to authorized users.;

520 a| "This book acts as a comprehensive guide about the principles, methods, and applications of structure-based drug discovery. It includes successful examples as well as recent developments in the field. Part 1 of the book covers necessary information and concepts of applying structural biology in the drug discovery process. It provides experimental and computational approaches to drug characterization and evaluation, an overview of fragment-based drug design, and a description of how to combine structural, thermodynamic and kinetic information for hit-to-lead drug development. Part 2 covers novel tools and techniques related to drug discovery, like automated platforms for protein characterization, various types of crystallizations, and high-throughput crystallography. Part 3 features case studies of structure-based discovery on important, established but still challenging therapeutic target families, as well as on monoclonal antibodies as an example of biotherapeutics. The final section illustrates new frontiers and challenges in the field, like intrinsically disordered proteins, neglected diseases, or viral resistance, and promising techniques for the future (XFELs and cryo-EM). Altogether, this book is an up-to-date resource about structure-based drug discovery that provides academic and industry insights, novel concepts, and advances in a fast-growing field"--Provided by publisher.;

538 a| Mode of access: World Wide Web;

650 0 a| Drug development.=| ^A443888;

650 0 a| Molecular biology.=| ^A1446;

650 12 a| Drug Discoveryx| methods=| ^A1023263;

650 22 a| Molecular Biologyx| methods=| ^A918962;

650 22 a| Genetic Techniques=| ^A923240;

650 22 a| Drug Design=| ^A925973;

655 0 a| Electronic books.=| ^A491897;

700 1 a| Renaud, Jean-Paul,d| 1960-?| UNAUTHORIZED;

856 40 z| Full text available from Ebook Central - Academic Completeu| https://ebookcentral.proquest.com/lib/eastcarolina/detail.action?docID=6011633;

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Structural biology in drug discovery methods, techniques, and practices / edited by Jean-Paul Renaud.

Other author	Renaud, Jean-Paul, 1960-
Format	Electronic
Edition	First edition.
Publication Info	Hoboken, NJ : Wiley, 2020.
Description	xxviii, 660 pages ; 29 cm
Supplemental Content	Full text available from Ebook Central - Academic Complete
Subjects	Drug development. Molecular biology. Drug Discovery--methods. Molecular Biology--methods. Genetic Techniques Drug Design

Abstract	"This book acts as a comprehensive guide about the principles, methods, and applications of structure-based drug discovery. It includes successful examples as well as recent developments in the field. Part 1 of the book covers necessary information and concepts of applying structural biology in the drug discovery process. It provides experimental and computational approaches to drug characterization and evaluation, an overview of fragment-based drug design, and a description of how to combine structural, thermodynamic and kinetic information for hit-to-lead drug development. Part 2 covers novel tools and techniques related to drug discovery, like automated platforms for protein characterization, various types of crystallizations, and high-throughput crystallography. Part 3 features case studies of structure-based discovery on important, established but still challenging therapeutic target families, as well as on monoclonal antibodies as an example of biotherapeutics. The final section illustrates new frontiers and challenges in the field, like intrinsically disordered proteins, neglected diseases, or viral resistance, and promising techniques for the future (XFELs and cryo-EM). Altogether, this book is an up-to-date resource about structure-based drug discovery that provides academic and industry insights, novel concepts, and advances in a fast-growing field"--Provided by publisher.
Bibliography note	Includes bibliographical references and index.
Access restriction	Available only to authorized users.
Technical details	Mode of access: World Wide Web
Genre/form	Electronic books.
LCCN	2019015619
ISBN	9781118681015 (hardback)

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Structural biology in drug discovery methods, techniques, and practices / edited by Jean-Paul Renaud.

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