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001 on1397376615;

003 OCoLC;

005 20250120152008.0;

006 m o d ;

007 cr unu||||||||;

008 230915s2023 ncua obm 000 0 eng d;

035 a| (Sirsi) o1397376615;

035 a| (OCoLC)1397376615;

043 a| n-us-nc;

049 a| EREE;

090 a| QL391.N4;

100 1 a| Cash, Monica Storm,e| author.?| UNAUTHORIZED;

245 10 a| Impacts of environmentally relevant levels of the perfluorooctanoic acid (PFOA) replacement compound GenX (Hexafluoropropylene Oxide Dimer Acid) on feeding behavior, mitochondrial ROS, and gene expression in Caenorhabditis elegans /c| by Monica Storm Cash.;

264 1 a| [Greenville, N.C.] :b| [East Carolina University],c| 2023.;

300 a| 1 online resource (57 pages) :b| illustrations (some color);

336 a| textb| txt2| rdacontent;

337 a| computerb| c2| rdamedia;

338 a| online resourceb| cr2| rdacarrier;

347 a| text fileb| PDFc| 1.104 MB2| rda;

538 a| System requirements: Adobe Reader.;

538 a| Mode of access: World Wide Web.;

502 b| M.S.c| East Carolina Universityd| 2023.;

502 a| Presented to the Faculty of the Department of Biology;

500 a| Advisor: Xiaoping Pan;

500 a| Title from PDF t.p. (viewed November 26, 2024).;

520 3 a| Per- and polyfluoroalkyl substances (PFAS) are commercially manufactured chemicals known for widespread usage in different industries. Past research indicating negative health impacts and bioaccumulation in humans and the environment have resulted in the withdrawal and banning of some PFAS. GenX is a short-chained replacement for a long-chained PFAS, but an insufficient amount of research has been conducted on the potential health impacts of GenX to justify its growing prominence and its increasing exposures to humans and the environment, such as commercial dumping into residential waterways. GenX levels correlating to the concentrations found in the Cape Fear River were evaluated using Caenorhabditis elegans as a model organism to measure a neurological toxicity behavior, reactive oxygen species accumulation, and select genetic regulation changes. Neurological toxicity behavior in the form of pharyngeal pumping was used to determine if the excitatory effects of legacy PFAS apply to GenX and were found to have significantly substantive evidence. Potential symptoms mitochondrial toxicity in the form of semi-quantitative recordings of reactive oxygen species and genetic analysis of genes of interest were assessed as well with areas of further investigation identified.;

504 a| Includes bibliographical references.;

650 0 a| Caenorhabditis elegansz| North Carolina.=| ^A627930;

650 0 a| GenX (Trademark)=| ^A1439783;

650 0 a| Active oxygen.=| ^A81680;

651 0 a| Cape Fear River (N.C.)=| ^A74308;

650 0 a| Perfluorinated chemicals.=| ^A1374320;

653 a| environmental toxicity;

653 a| mitochondrial toxicity;

653 a| pharyngeal pumping;

653 a| reactive oxygen species (ROS);

700 1 a| Pan, Xiaopingc| (Professor of biology),e| degree supervisor.=| ^A1443924;

710 2 a| East Carolina University.b| Department of Biology.=| ^A637467;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/13178;

949 o| wjh;

994 a| C0b| ERE;

596 a| 1 4;

998 a| 6234546;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 6234546-1001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 9/15/2023x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 6234546-2001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 9/15/2023x| ETDz| HERESOURCE;

Impacts of environmentally relevant levels of the perfluorooctanoic acid (PFOA) replacement compound GenX (Hexafluoropropylene Oxide Dimer Acid) on feeding behavior, mitochondrial ROS, and gene expression in Caenorhabditis elegans / by Monica Storm Cash.

Author/creator	Cash, Monica Storm author.
Other author	Pan, Xiaoping (Professor of biology), degree supervisor.
Other author	East Carolina University. Department of Biology.
Format	Theses and dissertations
Publication	[Greenville, N.C.] : [East Carolina University], 2023.
Description	1 online resource (57 pages) : illustrations (some color)
Supplemental Content	Access via ScholarShip
Subjects	Caenorhabditis elegans--North Carolina. GenX (Trademark) Active oxygen. Perfluorinated chemicals. Cape Fear River (N.C.)

Summary	Per- and polyfluoroalkyl substances (PFAS) are commercially manufactured chemicals known for widespread usage in different industries. Past research indicating negative health impacts and bioaccumulation in humans and the environment have resulted in the withdrawal and banning of some PFAS. GenX is a short-chained replacement for a long-chained PFAS, but an insufficient amount of research has been conducted on the potential health impacts of GenX to justify its growing prominence and its increasing exposures to humans and the environment, such as commercial dumping into residential waterways. GenX levels correlating to the concentrations found in the Cape Fear River were evaluated using Caenorhabditis elegans as a model organism to measure a neurological toxicity behavior, reactive oxygen species accumulation, and select genetic regulation changes. Neurological toxicity behavior in the form of pharyngeal pumping was used to determine if the excitatory effects of legacy PFAS apply to GenX and were found to have significantly substantive evidence. Potential symptoms mitochondrial toxicity in the form of semi-quantitative recordings of reactive oxygen species and genetic analysis of genes of interest were assessed as well with areas of further investigation identified.
General note	Advisor: Xiaoping Pan
General note	Title from PDF t.p. (viewed November 26, 2024).
Dissertation note	M.S. East Carolina University 2023.
Dissertation note	Presented to the Faculty of the Department of Biology
Bibliography note	Includes bibliographical references.
Technical details	System requirements: Adobe Reader.
Technical details	Mode of access: World Wide Web.

Impacts of environmentally relevant levels of the perfluorooctanoic acid (PFOA) replacement compound GenX (Hexafluoropropylene Oxide Dimer Acid) on feeding behavior, mitochondrial ROS, and gene expression in Caenorhabditis elegans / by Monica Storm Cash.

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