The effects of median eminence morphine and naloxone implants on pituitary [beta]-endorphin in male rats / by Jeffrey T. Johnson.
| Author/creator | Johnson, Jeffrey T. author. |
| Other author | Hodson, Charles A., degree supervisor. |
| Other author | Kalmus, Gerhard W., degree supervisor. |
| Other author | East Carolina University. Department of Biology. |
| Format | Theses and dissertations |
| Production | 1995. |
| Description | 47 leaves : illustrations ; 28 cm |
| Supplemental Content | Access via ScholarShip |
| Subjects |
| Summary | The purpose of this thesis is to determine if there is short-loop negative feedback regulation by the anterior pituitary of [beta]-endorphin release in male rats. To test this hypothesis, implants of morphine, an opiate agonist, naloxone, an opiate antagonist, or vehicle were surgically placed in the median eminence of male Sprague Dawley rats. The resulting levels of serum and anterior pituitary [beta]-endorphin were observed after six days. Morphine implants produced a significant decrease in anterior pituitary [beta]-endorphin, but caused an increase in serum [beta]-endorphin. Naloxone implants produced no significant change in anterior pituitary [beta]-endorphin, but caused an increase in serum [beta]-endorphin. Serum and pituitary levels of lutenizing hormone (LH) and prolactin (PRL) were also observed. From the results obtained in this study, there appears to be evidence of a short-loop opiate regulation for the control of anterior pituitary hormone release, but it appears that short-loop self-regulation of anterior pituitary [beta]-endorphin is unlikely. |
| General note | Submitted to the faculty of the Department of Biology. |
| General note | Advisor: Charles A. Hodson |
| General note | Advisor: Gerhard W. Kalmus |
| Dissertation note | M.S. East Carolina University 1995 |
| Bibliography note | Includes bibliographical references (leaves 42-47). |
| Genre/form | dissertations. |
| Genre/form | Academic theses. |
| Genre/form | Academic theses. |
| Genre/form | Thèses et écrits académiques. |
Availability
| Library | Location | Call Number | Status | Item Actions |
|---|---|---|---|---|
| Joyner | University Archives | ASK AT SPECIAL COLLECTIONS DESK | ✔ Available | Request Material |
| Electronic Resources | Access Content Online | ✔ Available |