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035 a| (Sirsi) o39221331;

035 a| (OCoLC)39221331;

049 a| EREE;

050 4 a| GV447b| .H57 1997;

100 1 a| Hird, Julie C.,e| author.?| UNAUTHORIZED;

245 14 a| The effect of seven days of endurance training on GLUT-4 protein concentration in aged subjects /c| by Julie C. Hird.;

264 0 c| 1997.;

300 a| viii, 90 leaves :b| illustrations, forms ;c| 28 cm;

336 a| textb| txt2| rdacontent;

337 a| unmediatedb| n2| rdamedia;

338 a| volumeb| nc2| rdacarrier;

502 b| M.A.c| East Carolina Universityd| 1997;

500 a| Submitted to the faculty of the Department of Exercise and Sport Science.;

500 a| Advisor: Joseph Houmard;

520 3 a| The purpose of this experiment was to determine if 7 days of endurance exercise at a relative training intensity of 70-75% of VO₂max can increase GLUT-4 protein concentration and insulin action in 50-70 year old, sedentary subjects to the same degree as that of younger subjects. Nine young female subjects (average age 22.4 + .8 years), 10 aged female subjects (60.9 ± 1 years), 9 young male subjects (20.9 + .9 years), and 8 aged males (56.5 + 1.9 years) participated. Each subject performed a cycle ergometer VO₂max and had body composition measured by 7-site skinfolds prior to the program. Subjects then exercised for one hour per day for seven consecutive days on a cycle ergometer at 70-75% of VO₂max. A pre- and post-training muscle biopsy was taken from the vastus lateralis to determine GLUT-4 protein concentration, and an intravenous glucose tolerance test (1VGTT) was used to determine insulin action. Muscle samples were analyzed using a western blot method and insulin action was analyzed by the Bergman minimal model. Results from the minimal model showed a 1.4 fold increase in insulin action in both groups of young subjects with training, a 1.8 fold increase in aged males, and a 2.2 fold increase in aged females. All increases were significant (p[less-than].05). The aged males increased insulin action at the same rate as the young subjects, but absolute values were significantly lower (p=.017), with an insulin sensitivity index of 2.1 in aged males vs. 4.5 in young males prior to exercise training, and 3.8 vs. 6.4 post- training. The aged females' insulin action did not significantly differ (p=.933) from young females' and it improved at a similar rate. GLUT-4 increased 1.5 fold with training in both groups of females, 1.9 fold in young males, and 2.1 fold in aged males. These changes were all significant (p[less-than-or-equal-to].02). Seven days of endurance training at a similar relative intensity can thus increase insulin action in aged subjects to a similar degree as that of young subjects. This improvement in insulin action could be due, at least in part, to an increase in GLUT-4 concentration in skeletal muscle.;

504 a| Includes bibliographical references (leaves 74-79).;

650 0 a| Exercise for older people.=| ^A5958;

650 7 a| Exercise for older people.2| fast0| (OCoLC)fst01199515;

655 7 a| Academic theses.2| fast0| (OCoLC)fst01726453;

655 7 a| Academic theses.2| lcgft;

655 7 a| Thèses et écrits académiques.2| rvmgf0| (CaQQLa)RVMGF-000001173;

700 1 a| Houmard, Joseph A.,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Exercise and Sport Science.?| UNAUTHORIZED;

856 41 z| Access via ScholarShipu| http://hdl.handle.net/10342/10043;

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The effect of seven days of endurance training on GLUT-4 protein concentration in aged subjects / by Julie C. Hird.

Author/creator	Hird, Julie C. author.
Other author	Houmard, Joseph A., degree supervisor.
Other author	East Carolina University. Department of Exercise and Sport Science.
Format	Theses and dissertations
Production	1997.
Description	viii, 90 leaves : illustrations, forms ; 28 cm
Supplemental Content	Access via ScholarShip
Subjects	Exercise for older people.

Summary	The purpose of this experiment was to determine if 7 days of endurance exercise at a relative training intensity of 70-75% of VO₂max can increase GLUT-4 protein concentration and insulin action in 50-70 year old, sedentary subjects to the same degree as that of younger subjects. Nine young female subjects (average age 22.4 + .8 years), 10 aged female subjects (60.9 ± 1 years), 9 young male subjects (20.9 + .9 years), and 8 aged males (56.5 + 1.9 years) participated. Each subject performed a cycle ergometer VO₂max and had body composition measured by 7-site skinfolds prior to the program. Subjects then exercised for one hour per day for seven consecutive days on a cycle ergometer at 70-75% of VO₂max. A pre- and post-training muscle biopsy was taken from the vastus lateralis to determine GLUT-4 protein concentration, and an intravenous glucose tolerance test (1VGTT) was used to determine insulin action. Muscle samples were analyzed using a western blot method and insulin action was analyzed by the Bergman minimal model. Results from the minimal model showed a 1.4 fold increase in insulin action in both groups of young subjects with training, a 1.8 fold increase in aged males, and a 2.2 fold increase in aged females. All increases were significant (p[less-than].05). The aged males increased insulin action at the same rate as the young subjects, but absolute values were significantly lower (p=.017), with an insulin sensitivity index of 2.1 in aged males vs. 4.5 in young males prior to exercise training, and 3.8 vs. 6.4 post- training. The aged females' insulin action did not significantly differ (p=.933) from young females' and it improved at a similar rate. GLUT-4 increased 1.5 fold with training in both groups of females, 1.9 fold in young males, and 2.1 fold in aged males. These changes were all significant (p[less-than-or-equal-to].02). Seven days of endurance training at a similar relative intensity can thus increase insulin action in aged subjects to a similar degree as that of young subjects. This improvement in insulin action could be due, at least in part, to an increase in GLUT-4 concentration in skeletal muscle.
General note	Submitted to the faculty of the Department of Exercise and Sport Science.
General note	Advisor: Joseph Houmard
Dissertation note	M.A. East Carolina University 1997
Bibliography note	Includes bibliographical references (leaves 74-79).
Genre/form	Academic theses.
Genre/form	Academic theses.
Genre/form	Thèses et écrits académiques.

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