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LEADER 03496ctm 2200565 i 4500

001 ocm39315034;

003 OCoLC;

005 20241021155025.0;

008 980619s1997 xx a bm 000 0 eng d;

035 a| (Sirsi) o39315034;

035 a| (OCoLC)39315034;

049 a| EREE;

050 4 a| QL668.C28b| J46 1997;

100 1 a| Jenkins, Nelson L,e| author.?| UNAUTHORIZED;

245 10 a| Plasma calcium regulation following parathyroidectomy in the red- spotted newt, Notophthalmus viridescens /c| by Nelson L. Jenkins.;

264 0 c| 1997.;

300 a| 53 leaves :b| illustrations (some color) ;c| 28 cm;

336 a| textb| txt2| rdacontent;

337 a| unmediatedb| n2| rdamedia;

338 a| volumeb| nc2| rdacarrier;

502 b| M.A.c| East Carolina Universityd| 1997;

500 a| Submitted to the faculty of the Department of Biology.;

500 a| Advisor: Charles A. Singhas;

520 3 a| The present study utilizes immunohistochemistry and SDS-Polyacrylamide gel electrophoresis to examine plasma calcium regulation following parathyroidectomy in the red-spotted newt, Nolophihalmus viridescens. The parathyroid gland of certain urodele amphibians is known to be an important regulator of calcium homeostasis. Following parathyroidectomy (PTX) in the red-spotted newt, calcium levels drop significantly but return to normal within 12-14 days At present, the mechanism by which this occurs is not known. This study examines the role of L25-dihydroxyvitamin D3 and the possible existence of a parathyroid hormone related peptide (PTHrp) in restoring plasma calcium levels following PTX. Results suggest that Vitamin D;, does not independently regulate plasma calcium in the absence of PTH and provides preliminary evidence for the presence of a PTHrp of renal origin as the calcemic factor in this species.;

504 a| Includes bibliographical references (leaves 48-51).;

650 0 a| Notophthalmus viridescens.=| ^A348045;

650 0 a| Parathyroid hormone.=| ^A110851;

650 0 a| Parathyroidectomy.=| ^A400478;

650 2 a| Notophthalmus viridescens.0| (DNLM)D009673=| ^A1458955;

650 2 a| Parathyroid Hormone.0| (DNLM)D010281=| ^A1203576;

650 2 a| Parathyroidectomy.0| (DNLM)D016105=| ^A1473689;

655 2 a| Academic Dissertation.0| (DNLM)D019478?| UNAUTHORIZED;

650 7 a| Notophthalmus viridescens.2| fast0| (OCoLC)fst01039639;

650 7 a| Parathyroid hormone.2| fast0| (OCoLC)fst01053221;

650 7 a| Parathyroidectomy.2| fast0| (OCoLC)fst01053226;

655 7 a| Academic theses.2| fast0| (OCoLC)fst01726453;

655 7 a| Academic theses.2| lcgft;

655 7 a| Thèses et écrits académiques.2| rvmgf0| (CaQQLa)RVMGF-000001173;

700 1 a| Singhas, Charles A.,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Biology.=| ^A637467;

856 41 z| Access via ScholarShipu| http://hdl.handle.net/10342/12512;

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Plasma calcium regulation following parathyroidectomy in the red- spotted newt, Notophthalmus viridescens / by Nelson L. Jenkins.

Author/creator	Jenkins, Nelson L author.
Other author	Singhas, Charles A., degree supervisor.
Other author	East Carolina University. Department of Biology.
Format	Theses and dissertations
Production	1997.
Description	53 leaves : illustrations (some color) ; 28 cm
Supplemental Content	Access via ScholarShip
Subjects	Notophthalmus viridescens. Parathyroid hormone. Parathyroidectomy. Notophthalmus viridescens. Parathyroid Hormone. Parathyroidectomy.

Summary	The present study utilizes immunohistochemistry and SDS-Polyacrylamide gel electrophoresis to examine plasma calcium regulation following parathyroidectomy in the red-spotted newt, Nolophihalmus viridescens. The parathyroid gland of certain urodele amphibians is known to be an important regulator of calcium homeostasis. Following parathyroidectomy (PTX) in the red-spotted newt, calcium levels drop significantly but return to normal within 12-14 days At present, the mechanism by which this occurs is not known. This study examines the role of L25-dihydroxyvitamin D3 and the possible existence of a parathyroid hormone related peptide (PTHrp) in restoring plasma calcium levels following PTX. Results suggest that Vitamin D;, does not independently regulate plasma calcium in the absence of PTH and provides preliminary evidence for the presence of a PTHrp of renal origin as the calcemic factor in this species.
General note	Submitted to the faculty of the Department of Biology.
General note	Advisor: Charles A. Singhas
Dissertation note	M.A. East Carolina University 1997
Bibliography note	Includes bibliographical references (leaves 48-51).
Genre/form	Academic theses.
Genre/form	Academic theses.
Genre/form	Thèses et écrits académiques.

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Plasma calcium regulation following parathyroidectomy in the red- spotted newt, Notophthalmus viridescens / by Nelson L. Jenkins.

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