Lipid-Based Drug Delivery Systems : Principles and Applications.
| Author/creator | Prajapati, Bhupendra |
| Other author | Patel, Jayvadan K. |
| Format | Electronic |
| Publication Info | Milton : Jenny Stanford Publishing, 2023. |
| Description | 1 online resource (837 pages) |
| Supplemental Content | Direct link to eBook |
| Subjects |
| Contents | Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Preface -- Acknowledgments -- Chapter 1: Lipid-Based Excipients: The Holy Grail in Pharmaceutical Product Development -- 1.1: Introduction -- 1.2: Lipidic Excipients Used in Drug Product Development -- 1.2.1: Glyceryl Dibehenate/Compritol 888 -- 1.2.2: Dynasan -- 1.2.3: Glyceryl Distearate -- 1.2.4: Glyceryl Caprylate -- 1.2.5: Gelucire -- 1.2.6: Labrasol (Caprylocaproyl Macrogol-8: Glyceride) -- 1.2.7: Medium Chain Triglyceride (MCT) -- 1.2.8: Glyceryl Stearate -- 1.2.9: Labrafil -- 1.2.10: Capryol (Propylene Glycol) |
| Contents | 1.2.11: Transcutol -- 1.2.12: Lauroglycol -- 1.2.13: Trimyristin -- 1.2.14: Tristearin/Glyceryl Tristearate -- 1.2.15: Glyceryl Monocaprylate -- 1.3: Absorption of Lipid Formulations -- 1.4: Formulation of Lipid-Based Formulations -- 1.4.1: Spray Congealing/Cooling -- 1.4.2: Spray Drying -- 1.4.3: Use of Solid Carriers for Adsorption -- 1.4.4: Melt Granulation -- 1.4.5: Supercritical Fluid-Based Method -- 1.4.6: Other Miscellaneous Formulation Techniques -- 1.4.6.1: Self-emulsifying drug carriers -- 1.4.6.2: Liposomes -- 1.4.6.3: Solid lipid nanoparticles |
| Contents | 1.4.6.4: Nanostructured lipid carriers (NLCs) -- 1.4.6.5: Nanoemulsion -- 1.4.6.6: Crystalline mesophases -- 1.4.6.7: Complexes -- 1.5: Vital Applications of Lipidic Excipients in Drug Carrier Systems -- 1.6: Regulatory Perspectives -- 1.7: Future Perspectives and Conclusions -- Chapter 2: Solid Lipid Nanoparticles -- 2.1: Introduction -- 2.2: SLNs Composition -- 2.2.1: Lipids -- 2.2.2: Surfactants -- 2.2.3: Other Ingredients -- 2.3: Drug Loading Models -- 2.4: Method of Preparation -- 2.4.1: High-Pressure Homogenization (HPH) -- 2.4.1.1: Hot homogenization -- 2.4.1.2: Cold homogenization |
| Contents | 2.4.2: Solvent Emulsification/Evaporation -- 2.4.3: Microemulsion Method -- 2.4.4: Solvent Injection Method -- 2.4.5: Double Emulsion Method -- 2.4.6: Ultrasonication Method or High-Speed Homogenization Method -- 2.4.7: Supercritical Fluid-Based Method -- 2.5: Drying Method of SLNs -- 2.5.1: Lyophilization -- 2.5.2: Spray Drying -- 2.6: Characterization of SLNs -- 2.7: Drug Release from SLNs -- 2.8: Storage Stability -- 2.9: Conclusion -- Chapter 3: Liposomal Drug Delivery Systems: Concept and Recent Advances in Clinical Applications -- 3.1: Introduction -- 3.2: General Characteristics |
| Contents | 3.3: Type of Liposome -- 3.4: Method of Preparation -- 3.4.1: Thin-Film Hydration -- 3.4.2: Reverse-Phase Evaporation -- 3.4.2.1: Injection -- 3.4.2.2: Detergent removal -- 3.4.2.3: Dehydration-rehydration -- 3.4.2.4: pH jumping -- 3.4.2.5: Freeze-thaw -- 3.4.2.6: Hydration in a packed bed of colloidal particles -- 3.5: Characterization of Liposomes -- 3.5.1: Entrapment Efficiency and Drug Release -- 3.5.2: Drug Release Study -- 3.5.3: Size, Zeta Potential, and Stability -- 3.5.4: Pharmacokinetics -- 3.6: Composition -- 3.6.1: Phospholipids -- 3.6.2: Sphingolipids -- 3.6.3: Sterols |
| Abstract | This book appraises the role of lipid-based drug delivery systems (LBDDSs) with respect to the bioavailability and controlled delivery of complex drug molecules for improving their clinical viability. |
| General note | Description based upon print version of record. |
| General note | 3.6.4: Polysaccharides |
| Biographical note | Bhupendra Prajapati is a professor at the Department of Pharmaceutics, Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Gujarat, India. Dr Prajapati has more than 20 years of academic and research experience. He has published 120 research papers, edited 10 books, and authored 38 book chapters. His research focuses on modified and novel drug delivery. His h-index and i10-index are 22 and 39, respectively, with more than 1800 citations. Jayvadan Patel is a formulation scientist at Aavis Pharmaceuticals, USA, and professor emeritus at the Faculty of Pharmacy, Sankalchand Patel University, India. Dr Patel has more than 26 years of experience in academics, research, and industry. He has published 270 research papers, co-authored 20 books, and contributed 122 book chapters. His papers have been cited more than 5600 times, and his h-index is 37 and i10-index is 126. |
| Issued in other form | Print version: Prajapati, Bhupendra Lipid-Based Drug Delivery Systems Milton : Jenny Stanford Publishing,c2023 9789814968928 |
| ISBN | 9781000995732 |
| ISBN | 1000995739 |
| ISBN | 9781003459811 (electronic bk.) |
| ISBN | 1003459811 (electronic bk.) |
| ISBN | 9781000995763 (electronic bk. : EPUB) |
| ISBN | 1000995763 (electronic bk. : EPUB) |
| Standard identifier# | 10.1201/9781003459811 |
| Stock number | 9781003459811 Taylor & Francis |
Availability
| Library | Location | Call Number | Status | Item Actions |
|---|---|---|---|---|
| Electronic Resources | Access Content Online | ✔ Available |