Endothelial progenitor cells in health and disease / Amankeldi A. Salybekov, MD, PhD, Shuzo Kobayashi, MD, PhD, Takayuki Asahara, MD, PhD editor.
| Other author | Salybekov, Amankeldi A. |
| Other author | Kobayashi, Shuzo. |
| Other author | Asahara, Takayuki. |
| Format | Electronic |
| Publication Info | New York : Nova Medicine & Health, [2022] |
| Description | viii, 191 pages : illustrations ; 24 cm. |
| Supplemental Content | Full text available from Ebook Central - Academic Complete |
| Subjects |
| Series | Cell biology research progress |
| Contents | Preface -- Section I. EPC Biological Function and Origin -- Advances in Endothelial Progenitor Cell Biology / Amankeldi A. Salybekov and Takayuki Asahara -- Section II. EPC in Cardiovascular Disease -- Diagnostic and Prognostic Potential of EPCs in Cardiovascular Diseases / Mehdi Hassanpour -- Epidemiology of Peripheral Artery Disease / Takayasu Ohtake MD, PhD, and Shuzo Kobayashi, MD, PhD -- Section III. EPC in Metabolic Diseases -- Endothelial Progenitors in Metabolic Diseases / Mattia Albiero and Gian Paolo Fadini -- Section IV. Clinical EPX Transplantation Trials -- Endothelial Progenitor Cell Therapy in Heart Disease - Pitfalls in Clinical Translation, Impact of Stem Cell Senescence, and Personalized Medicine by AI-Application / Gustav Steinhoff and Markus Wolfien -- EPC in Peripheral Arterial Diseases / Yasuyuki Fujita and Atsuhiko Kawamoto -- EPC in Kidney Diseases / Takayasu Ohtake MD, PhD, and Shuzo Kobayashi MD, PhD -- Section V. EPC Derived Extracellular Vesicles -- Therapeutic Applications of Endothelial Progenitor CellDerived Extracellular Vesicles in Cardiovascular Diseases / Junjie Yang and Jiacheng Sun -- Index |
| Abstract | "We are delighted to offer this textbook to the scientific community, entitled Endothelial Progenitor Cells in Health and Diseases, which covers a timely topic in the rapidly evolving discipline of vascular biology. Written primarily for a life science audience and clinicians, the fundamentals of EPCs biology and the latest characterization and definition in health and diseases are introduced, followed by explanations of the most cutting-edge cell therapy methods to cure ischemic diseases. In Section One, endothelial cell progenitor isolation methods and biological characterization were reported. The discovery of this novel endothelial progenitor cells (EPC) concept has overturned the previous dogma which suggested that vasculogenesis could only occur during embryogenesis. In fact, both vasculogenesis and angiogenesis may potentially have a synergistic role in postnatal revascularization. Also, this chapter summarized recent advances in EPC biology such as biological function, origin, definition, and classification. Each EPC culture and isolation method is clearly defined to prevent confusion in EPC biology. Section Two focuses on EPC biological function alteration in cardiovascular diseases (CVD). Several large clinical trials have reported that the number and biological function are strongly associated with major adverse cardiovascular events. The diagnostic and prognostic potential of EPC is crucial in terms of CVD. In Section Three, biological dysfunction mechanisms of EPC and their scarcity in diabetic patients' peripheral blood were clearly described. Preclinical studies have shown that EPC-based therapy is feasible, safe, and efficacious in multiple disease states. Subsequently, this has led to several clinical trials demonstrating the feasibility and safety profile of EPC therapy against cardiovascular ischemic diseases. In Section Four, regenerative medicine pioneers discussed EPCs translation to the clinic and cell transplantation challenges along with their solutions. Personalized stem cell-based therapy approaches employing several clinical biomarkers, disease-related genetic-trait evaluation methods, and advanced analyses with state-of-the-art computational methods such as machine learning-based prediction can increase cell therapies' efficacy and decrease treatment costs. The last chapter in the book describes a therapeutic application of EPC-derived extracellular vesicles to cure CVD"-- Provided by publisher. |
| General note | "Nova Medicine & Health"--Cover. |
| Bibliography note | Includes bibliographical references and index. |
| Access restriction | Available only to authorized users. |
| Technical details | Mode of access: World Wide Web |
| Genre/form | Electronic books. |
| LCCN | 2022020388 |
| ISBN | 9781685077945 (hardcover) |
| ISBN | (pdf) |
Availability
| Library | Location | Call Number | Status | Item Actions |
|---|---|---|---|---|
| Electronic Resources | Access Content Online | ✔ Available |