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100 1 a| D'Arrigo, Joseph S.?| UNAUTHORIZED;

245 10 a| Stable nanoemulsionsh| [electronic resource] :b| self-assembly in nature and nanomedicine /c| Joseph D'Arrigo.;

260 a| Amsterdam :b| Elsevier,;

300 a| xx, 415 p. :b| ill. ;c| 24 cm.;

490 1 a| Studies in interface science,x| 1383-7303 ;v| 25;

504 a| Includes bibliographical references (p. 343-409) and index.;

505 00 a| 1. Occurrence of dilute gas-in-liquid emulsions in natural waters -- 2. Early work with aqueous carbohydrate gels -- 3. Comparison of aqueous soil extracts with carbohydrate gels -- 4. Characteristic glycopeptide fraction of natural microbubble surfactant -- 5. Ecological chemistry of microbubble surfactant -- 6. Surface properties of microbubble-surfactant monolayers -- 7. Structure of predominant surfactant components stabilizing natural microbubbles -- 8. Stable microbubbles in physiological fluids: competing hypotheses -- 9. Concentrated gas-in-liquid emulsions in artificial media. I. Demonstration by laser-light scattering -- 10. Concentrated gas-in-liquid emulsions in artificial media. II. Characterization by photon correlation spectroscopy -- 11. Concentrated gas-in-liquid emulsions in artificial media. Ill. Review of molecular mechanisms involved in microbubble stabilization -- 12. Targeted imaging of tumors, and targeted cavitation therapy, with lipid-coated microbubbles (LCM) -- 13. Targeted drug-delivery therapy of tumors using LCM -- 14. Proposed mechanism of selective LCM uptake by tumor cells: role of lipoprotein receptor-mediated endocytic pathways -- 15. Endocytotic events versus particle size: multidisciplinary analyses demonstrate LCM sizes are mostly submicron -- 16. LCM and nanoparticle subpopulations for drug delivery -- 17. Composition of LCM governing interplay with nanoparticle subpopulation -- 18. Targeted nanoparticle subpopulation: comparison with self-nanoemulsifying drug-delivery systems in pharmaceutical research -- 19. Clinical development of an "LCM/Nanoparticle-Derived" formulation: a nanoemulsion based upon "Dispersed LMN" -- 20. Selected parenteral lipid nanoemulsions under clinical study: comparison concerning passive accumulation in tumors, active targeting of tumors, and validation status -- 21. Supplementary operational benefits concerning "LCM/Nanoparticle-Derived" formulations: relation to lipid-nanoemulsion structure -- 22. Biological lipid polymorphs: preferred cubic phase of "Dispersed LMN" -- 23. Nonlamellar phase(s) facilitating membrane fusion: endocytosis of dispersed LMN -- 24. Receptor-mediated endocytosis of (mixed-lipid) dispersed LMN -- 25. Further chemotherapy with lipid nanoemulsions: targeting certain hyperproliferative diseases, as well as neoplasias, via "Lipoprotein Receptor" -- mediated endocytosis -- 26. Related clinical trials and human epidemiological studies -- 27. Aspects of future R&D regarding targeted lipid nanoemulsions.;

506 a| Available only to authorized users.;

538 a| Mode of access: World Wide Web;

650 0 a| Emulsions.=| ^A61025;

650 0 a| Emulsions (Pharmacy)=| ^A880988;

650 0 a| Nanomedicine.=| ^A797884;

650 12 a| Nanoparticlesx| chemistry.=| ^A1098923;

650 22 a| Coated Materials, Biocompatible.?| UNAUTHORIZED;

650 22 a| Emulsionsx| chemistry.?| UNAUTHORIZED;

650 22 a| Microbubblesx| therapeutic use.?| UNAUTHORIZED;

650 22 a| Nanoparticlesx| therapeutic use.=| ^A1266890;

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830 0 a| Studies in interface science ;v| v. 25.x| 1383-7303=| ^A492464;

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Stable nanoemulsions self-assembly in nature and nanomedicine / Joseph D'Arrigo.

Author/creator	D'Arrigo, Joseph S.
Format	Electronic
Publication Info	Amsterdam : Elsevier,
Description	xx, 415 p. : ill. ; 24 cm.
Supplemental Content	Full text available from eBook - Chemical Engineering 2011 [EBCCE11]
Subjects	Emulsions. Emulsions (Pharmacy) Nanomedicine. Nanoparticles--chemistry. Coated Materials, Biocompatible. Emulsions--chemistry. Microbubbles--therapeutic use. Nanoparticles--therapeutic use.

Series	Studies in interface science, 1383-7303 ; 25 Studies in interface science ; v. 25. 1383-7303 ^A492464
Contents	1. Occurrence of dilute gas-in-liquid emulsions in natural waters -- 2. Early work with aqueous carbohydrate gels -- 3. Comparison of aqueous soil extracts with carbohydrate gels -- 4. Characteristic glycopeptide fraction of natural microbubble surfactant -- 5. Ecological chemistry of microbubble surfactant -- 6. Surface properties of microbubble-surfactant monolayers -- 7. Structure of predominant surfactant components stabilizing natural microbubbles -- 8. Stable microbubbles in physiological fluids: competing hypotheses -- 9. Concentrated gas-in-liquid emulsions in artificial media. I. Demonstration by laser-light scattering -- 10. Concentrated gas-in-liquid emulsions in artificial media. II. Characterization by photon correlation spectroscopy -- 11. Concentrated gas-in-liquid emulsions in artificial media. Ill. Review of molecular mechanisms involved in microbubble stabilization -- 12. Targeted imaging of tumors, and targeted cavitation therapy, with lipid-coated microbubbles (LCM) -- 13. Targeted drug-delivery therapy of tumors using LCM -- 14. Proposed mechanism of selective LCM uptake by tumor cells: role of lipoprotein receptor-mediated endocytic pathways -- 15. Endocytotic events versus particle size: multidisciplinary analyses demonstrate LCM sizes are mostly submicron -- 16. LCM and nanoparticle subpopulations for drug delivery -- 17. Composition of LCM governing interplay with nanoparticle subpopulation -- 18. Targeted nanoparticle subpopulation: comparison with self-nanoemulsifying drug-delivery systems in pharmaceutical research -- 19. Clinical development of an "LCM/Nanoparticle-Derived" formulation: a nanoemulsion based upon "Dispersed LMN" -- 20. Selected parenteral lipid nanoemulsions under clinical study: comparison concerning passive accumulation in tumors, active targeting of tumors, and validation status -- 21. Supplementary operational benefits concerning "LCM/Nanoparticle-Derived" formulations: relation to lipid-nanoemulsion structure -- 22. Biological lipid polymorphs: preferred cubic phase of "Dispersed LMN" -- 23. Nonlamellar phase(s) facilitating membrane fusion: endocytosis of dispersed LMN -- 24. Receptor-mediated endocytosis of (mixed-lipid) dispersed LMN -- 25. Further chemotherapy with lipid nanoemulsions: targeting certain hyperproliferative diseases, as well as neoplasias, via "Lipoprotein Receptor" -- mediated endocytosis -- 26. Related clinical trials and human epidemiological studies -- 27. Aspects of future R&D regarding targeted lipid nanoemulsions.
Bibliography note	Includes bibliographical references (p. 343-409) and index.
Access restriction	Available only to authorized users.
Technical details	Mode of access: World Wide Web
Genre/form	Electronic books.
LCCN	2011377871
ISBN	9780444537980
ISBN	0444537988

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Stable nanoemulsions self-assembly in nature and nanomedicine / Joseph D'Arrigo.

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