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001 ocm45058301;

003 OCoLC;

005 20260127093954.0;

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035 a| (Sirsi) o45058301;

035 a| (OCoLC)45058301;

049 a| EREE;

050 4 a| QL668.C28b| P84 1999;

100 1 a| Pulley, Jason E.,e| author.?| UNAUTHORIZED;

245 10 a| Effects of parathyroidectomy on the expression of glycoconjugates and pthrp in the kidney of the red-spotted newt, Notophthalmus viridescens /c| by Jason E. Pulley.;

264 0 c| 1999.;

300 a| 66 leaves :b| color illustrations ;c| 28 cm;

336 a| textb| txt2| rdacontent;

337 a| unmediatedb| n2| rdamedia;

338 a| volumeb| nc2| rdacarrier;

502 b| M.S.c| East Carolina Universityd| 1999;

500 a| Submitted to the faculty of the Department of Biology.;

500 a| Advisor: Charles Singhas;

520 0 a| The present study utilizes lectin histochemistry and immunohistochemistry to examine the expression of glycoconjugates and parathyroid hormone-related peptide in the kidney of the red-spotted newt following parathyroidectomy. The parathyroid gland is known to be an important regulator of calcium homeostasis in vertebrates. Following parathyroidectomy in the red-spotted newt, calcium levels drop significantly but return to normal within 14 days. Results of lectin histochemistry revealed that parathyroidectomy affected glycoconjugates within proximal tubules of the newt kidney. Results show proximal tubule cells accumulated granules, which bound PTHrP antibody and also reacted to lectins specific for oligosaccharides associated with secretory proteins. These results suggest PTHrP may play a role in restoring plasma calcium following parathyroidectomy. The presence of granules, which bind PTHrP antibodies, suggests PTHrP is produced in the kidney and serves an autocrine or paracrine role as the calcemic factor in this species.;

504 a| Includes bibliographical references (leaves 61-63).;

650 0 a| Notophthalmus viridescensx| Physiology.=| ^A348045;

650 0 a| Parathyroid hormone.=| ^A110851;

650 0 a| Parathyroid hormone-related protein.=| ^A462010;

650 2 a| Parathyroid Hormone.0| (DNLM)D010281=| ^A1203576;

650 2 a| Parathyroid Hormone-Related Protein.0| (DNLM)D044162=| ^A1205311;

655 2 a| Academic Dissertation.0| (DNLM)D019478?| UNAUTHORIZED;

650 7 a| Notophthalmus viridescensx| Physiology.2| fast0| (OCoLC)fst01039640;

650 7 a| Parathyroid hormone.2| fast0| (OCoLC)fst01053221;

650 7 a| Parathyroid hormone-related protein.2| fast0| (OCoLC)fst01053224;

655 7 a| Academic theses.2| fast0| (OCoLC)fst01726453;

655 7 a| Academic theses.2| lcgft;

655 7 a| Thèses et écrits académiques.2| rvmgf0| (CaQQLa)RVMGF-000001173;

700 1 a| Singhas, Charles A.,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Biology.=| ^A637467;

856 41 z| Access via ScholarShipu| http://hdl.handle.net/10342/12682;

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Effects of parathyroidectomy on the expression of glycoconjugates and pthrp in the kidney of the red-spotted newt, Notophthalmus viridescens / by Jason E. Pulley.

Author/creator	Pulley, Jason E. author.
Other author	Singhas, Charles A., degree supervisor.
Other author	East Carolina University. Department of Biology.
Format	Theses and dissertations
Production	1999.
Description	66 leaves : color illustrations ; 28 cm
Supplemental Content	Access via ScholarShip
Subjects	Notophthalmus viridescens--Physiology. Parathyroid hormone. Parathyroid hormone-related protein. Parathyroid Hormone. Parathyroid Hormone-Related Protein.

Subject	The present study utilizes lectin histochemistry and immunohistochemistry to examine the expression of glycoconjugates and parathyroid hormone-related peptide in the kidney of the red-spotted newt following parathyroidectomy. The parathyroid gland is known to be an important regulator of calcium homeostasis in vertebrates. Following parathyroidectomy in the red-spotted newt, calcium levels drop significantly but return to normal within 14 days. Results of lectin histochemistry revealed that parathyroidectomy affected glycoconjugates within proximal tubules of the newt kidney. Results show proximal tubule cells accumulated granules, which bound PTHrP antibody and also reacted to lectins specific for oligosaccharides associated with secretory proteins. These results suggest PTHrP may play a role in restoring plasma calcium following parathyroidectomy. The presence of granules, which bind PTHrP antibodies, suggests PTHrP is produced in the kidney and serves an autocrine or paracrine role as the calcemic factor in this species.
General note	Submitted to the faculty of the Department of Biology.
General note	Advisor: Charles Singhas
Dissertation note	M.S. East Carolina University 1999
Bibliography note	Includes bibliographical references (leaves 61-63).
Genre/form	Academic theses.
Genre/form	Academic theses.
Genre/form	Thèses et écrits académiques.

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Effects of parathyroidectomy on the expression of glycoconjugates and pthrp in the kidney of the red-spotted newt, Notophthalmus viridescens / by Jason E. Pulley.

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