Hypothalamic regulation of glucose tolerance / by Michael T. Davis.
| Author/creator | Davis, Michael T. author. |
| Other author | Hodson, Charles A., degree supervisor. |
| Other author | Singhas, Charles A., degree supervisor. |
| Other author | East Carolina University. Department of Biology. |
| Format | Theses and dissertations |
| Production | 1999. |
| Description | 63 leaves : illustrations ; 28 cm |
| Supplemental Content | Access via ScholarShip |
| Subjects |
| Summary | The purpose of this thesis is to determine if neuropeptides can modulate glucose metabolism via the hypothalamus. To test this hypothesis, neuropeptide Y, cholecystokinin, leptin or bovine serum albumin were infused into the third ventricle of fasted male Sprague Dawley rats, alone and in conjunction with an intraperitoneal glucose load (2g/ kg b.w.). The resulting serum glucose levels were tested using blood collected from the tail vein. Intracerebroventricular administration of cholecystokinin and leptin did not alter plasma glucose levels when administered alone or in the company of a glucose load. Centrally administered neuropeptide Y resulted in significant reductions in plasma glucose levels when infused alone and with a glucose load. Upon completion of the glucose tolerance tests, serum levels of prolactin, luteinizing hormone and insulin were measured and functioned as controls and as tests of the efficacy of the study. None of the test peptides produced any significant changes in serum levels of prolactin, luteinizing hormone or insulin. From the results observed in this study, there appears to be evidence of hypothalamic regulation of glucose metabolism with respect to neuropeptide Y, but it appears that central regulation of plasma glucose by leptin and cholecystokinin is unlikely, within the parameters of this study. |
| General note | Submitted to the faculty of the Department of Biology. |
| General note | Advisor: Charles A. Hodson |
| General note | Advisor: Charles A. Singhas |
| Dissertation note | M.S. East Carolina University 1999 |
| Bibliography note | Includes bibliographical references (leaves 50-59). |
| Genre/form | dissertations. |
| Genre/form | Academic theses. |
| Genre/form | Academic theses. |
| Genre/form | Thèses et écrits académiques. |
Availability
| Library | Location | Call Number | Status | Item Actions |
|---|---|---|---|---|
| Joyner | University Archives | ASK AT SPECIAL COLLECTIONS DESK | ✔ Available | Request Material |
| Electronic Resources | Access Content Online | ✔ Available |