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003 OCoLC;

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035 a| (Sirsi) o56351411;

035 a| (OCoLC)56351411;

049 a| EREE;

050 4 a| QH603.M5b| B84 2002;

100 1 a| Burr, Patrick C.,e| author.?| UNAUTHORIZED;

245 10 a| Initial characterization of the genomic structure of the human mitochondrial elongation factor Ts gene /c| by Patrick C. Burr.;

264 0 c| 2002.;

300 a| 68 leaves :b| illustrations ;c| 28 cm;

336 a| textb| txt2| rdacontent;

337 a| unmediatedb| n2| rdamedia;

338 a| volumeb| nc2| rdacarrier;

502 b| M.S.c| East Carolina Universityd| 2002;

500 a| Presented to the faculty of the Department of Biology.;

500 a| Advisor: Mary Farwell;

520 3 a| Mitochondria are highly specialized sub-cellular compartments that carry out a multitude of critical tasks within the eukaryotic cells in which they reside. Mitochondria have a number of interesting features including the presence of a separate and distinct genome that is replicated, transcribed and translated with substantial help from nuclear gene products. The human mitochondrial elongation factor Ts (EF-Ts) gene (TSFM) is such an example. The protein product of this gene operates during the elongation phase of mitochondrial protein synthesis. Therefore, a detailed understanding of the structure and function of this gene could lead to an understanding of the regulation of protein synthesis in the mitochondria. Here, I report the characterization of the partial structure of the human mitochondrial EF-Ts gene. This was achieved through the automated DNA sequencing and analysis of nearly 14.3 kilobasepairs of sequence data comprising the entire insert of a single lambda clone from a human genomic library.;

504 a| Includes bibliographical references (leaves 55-56).;

650 0 a| Mitochondrial DNA.=| ^A348042;

650 0 a| Mitochondrial pathology.=| ^A576127;

650 0 a| Human gene libraries.=| ^A581543;

650 0 a| Proteinsx| Synthesis.=| ^A204728;

650 7 a| Human gene libraries.2| fast0| (OCoLC)fst00963065;

650 7 a| Mitochondrial DNA.2| fast0| (OCoLC)fst01024018;

650 7 a| Mitochondrial pathology.2| fast0| (OCoLC)fst01024022;

650 7 a| Proteinsx| Synthesis.2| fast0| (OCoLC)fst01079764;

655 7 a| dissertations.2| aat0| (CStmoGRI)aatgf300028029;

655 7 a| Academic theses.2| fast0| (OCoLC)fst01726453;

655 7 a| Academic theses.2| lcgft;

655 7 a| Thèses et écrits académiques.2| rvmgf0| (CaQQLa)RVMGF-000001173;

700 1 a| Farwell, Mary A.,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Biology.=| ^A637467;

856 40 z| Access via ScholarShipu| http://hdl.handle.net/10342/11894;

949 a| Click on web addressw| asish| joyner101;

949 a| Click on web addressw| asish| hsl111;

994 a| C0b| ERE;

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998 a| 968933;

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Initial characterization of the genomic structure of the human mitochondrial elongation factor Ts gene / by Patrick C. Burr.

Author/creator	Burr, Patrick C. author.
Other author	Farwell, Mary A., degree supervisor.
Other author	East Carolina University. Department of Biology.
Format	Theses and dissertations
Production	2002.
Description	68 leaves : illustrations ; 28 cm
Supplemental Content	Access via ScholarShip
Subjects	Mitochondrial DNA. Mitochondrial pathology. Human gene libraries. Proteins--Synthesis.

Summary	Mitochondria are highly specialized sub-cellular compartments that carry out a multitude of critical tasks within the eukaryotic cells in which they reside. Mitochondria have a number of interesting features including the presence of a separate and distinct genome that is replicated, transcribed and translated with substantial help from nuclear gene products. The human mitochondrial elongation factor Ts (EF-Ts) gene (TSFM) is such an example. The protein product of this gene operates during the elongation phase of mitochondrial protein synthesis. Therefore, a detailed understanding of the structure and function of this gene could lead to an understanding of the regulation of protein synthesis in the mitochondria. Here, I report the characterization of the partial structure of the human mitochondrial EF-Ts gene. This was achieved through the automated DNA sequencing and analysis of nearly 14.3 kilobasepairs of sequence data comprising the entire insert of a single lambda clone from a human genomic library.
General note	Presented to the faculty of the Department of Biology.
General note	Advisor: Mary Farwell
Dissertation note	M.S. East Carolina University 2002
Bibliography note	Includes bibliographical references (leaves 55-56).
Genre/form	dissertations.
Genre/form	Academic theses.
Genre/form	Academic theses.
Genre/form	Thèses et écrits académiques.

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Initial characterization of the genomic structure of the human mitochondrial elongation factor Ts gene / by Patrick C. Burr.

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