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049 a| EREE;

050 4 a| QP752.F35b| S36 2004;

100 1 a| Sandhoff, Kimberly M.?| UNAUTHORIZED;

245 14 a| The effects of 10 days of endurance exercise training on skeletal muscle fatty acid oxidation in obese African-American and Caucasian women /c| by Kimberly M. Sandhoff.;

264 0 c| 2004.;

300 a| 99 leaves :b| illustrations (some color), forms ;c| 28 cm;

336 a| textb| txt2| rdacontent;

337 a| unmediatedb| n2| rdamedia;

338 a| volumeb| nc2| rdacarrier;

502 b| M.A.c| East Carolina Universityd| 2004;

500 a| Presented by the faculty of the Department of Exercise and Sport Science.;

500 a| Advisor: Ronald N. Cortright;

520 3 a| Obesity has been associated with impairments in skeletal muscle (SkM) fatty acid oxidation and insulin resistance. African-American women (AAW) are recognized to have an increased incidence of obesity and diabetes vs. Caucasian women (CW). Endurance exercise training (EET) increases the oxidative capacity of SkM and therefore the purpose of this study was to determine the effects of 10 days of EET on fatty acid oxidation in sedentary, obese AAW vs. CW. Hypothesis: Both obese AAW and CW women will demonstrate improvements in their skeletal muscle's capacity to oxidize fatty acids following EET. Methods: Seven CW (age 35.1 ± 2.94 yrs; BMI 39.9 ± 1.26 kg/m2; V02peak 1.89 ± 0.11 L/min; mean ± SEM) and 9 AAW (age 35.0 ± 0.83; BMI 36.5 ± 1.19; V02peak 1.66 ± 0.14) underwent 10 consecutive days of EET on a cycle ergometer for 60 min/d at a work rate corresponding to 70-75% of V02peak. Results: Oxidation rates of [ 1 -l4C] palmitate were determined in SkM homogenates from the vastus lateralis pre- and post- EET. Basal rates of palmitate oxidation were lower (P = 0.05) in AAW vs. CW. AAW displayed a mean percent increase of 212% in palmitate oxidation (30.28 ± 6.17 to 60.7 ± 6.89 nmol/g protein/min; P < 0.05), whereas CW increased 159% (45.7 ± 6.50 to 73.2 ± 5.8; P < 0.05). Similar findings occurred when oxidation rates for palmitoyl-CoA and palmitoyl-camitine were compared pre- to post- EET, suggesting improvements in SkM oxidative capacity at the level of activation, translocation and post-translocation of fatty acids into the mitochondria. Conclusion: The capacity of SkM to oxidize fatty acids in obese AAW and CW was increased after 10 days of EET, suggesting that EET is an effective treatment for obesity in both racial groups.;

504 a| Included bibliographical references (leaves 62-69).;

650 0 a| Fatty acidsx| Metabolism.=| ^A6638;

650 0 a| Exercise for women.=| ^A501;

650 0 a| Obesity in womenx| Physiological aspects.=| ^A466827;

650 0 a| African American womenx| Physiology.=| ^A23816;

650 0 a| Women, Whitex| Physiology.=| ^A524111;

650 0 a| Overweight womenx| Physiology.=| ^A295011;

650 7 a| Exercise for women.2| fast0| (OCoLC)fst00918045;

650 7 a| Fatty acidsx| Metabolism.2| fast0| (OCoLC)fst00921964;

655 7 a| Academic theses.2| fast0| (OCoLC)fst01726453;

655 7 a| Academic theses.2| lcgft;

655 7 a| Thèses et écrits académiques.2| rvmgf0| (CaQQLa)RVMGF-000001173;

655 2 a| Academic Dissertation.0| (DNLM)D019478?| UNAUTHORIZED;

700 1 a| Cortright, Ronald N.,e| degree supervisor.?| UNAUTHORIZED;

710 2 a| East Carolina University.b| Department of Exercise and Sport Science.?| UNAUTHORIZED;

856 41 z| Access via ScholarShipu| http://hdl.handle.net/10342/10252;

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The effects of 10 days of endurance exercise training on skeletal muscle fatty acid oxidation in obese African-American and Caucasian women / by Kimberly M. Sandhoff.

Author/creator	Sandhoff, Kimberly M.
Other author	Cortright, Ronald N., degree supervisor.
Other author	East Carolina University. Department of Exercise and Sport Science.
Format	Theses and dissertations
Production	2004.
Description	99 leaves : illustrations (some color), forms ; 28 cm
Supplemental Content	Access via ScholarShip
Subjects	Fatty acids--Metabolism. Exercise for women. Obesity in women--Physiological aspects. African American women--Physiology. Women, White--Physiology. Overweight women--Physiology.

Summary	Obesity has been associated with impairments in skeletal muscle (SkM) fatty acid oxidation and insulin resistance. African-American women (AAW) are recognized to have an increased incidence of obesity and diabetes vs. Caucasian women (CW). Endurance exercise training (EET) increases the oxidative capacity of SkM and therefore the purpose of this study was to determine the effects of 10 days of EET on fatty acid oxidation in sedentary, obese AAW vs. CW. Hypothesis: Both obese AAW and CW women will demonstrate improvements in their skeletal muscle's capacity to oxidize fatty acids following EET. Methods: Seven CW (age 35.1 ± 2.94 yrs; BMI 39.9 ± 1.26 kg/m2; V02peak 1.89 ± 0.11 L/min; mean ± SEM) and 9 AAW (age 35.0 ± 0.83; BMI 36.5 ± 1.19; V02peak 1.66 ± 0.14) underwent 10 consecutive days of EET on a cycle ergometer for 60 min/d at a work rate corresponding to 70-75% of V02peak. Results: Oxidation rates of [ 1 -l4C] palmitate were determined in SkM homogenates from the vastus lateralis pre- and post- EET. Basal rates of palmitate oxidation were lower (P = 0.05) in AAW vs. CW. AAW displayed a mean percent increase of 212% in palmitate oxidation (30.28 ± 6.17 to 60.7 ± 6.89 nmol/g protein/min; P < 0.05), whereas CW increased 159% (45.7 ± 6.50 to 73.2 ± 5.8; P < 0.05). Similar findings occurred when oxidation rates for palmitoyl-CoA and palmitoyl-camitine were compared pre- to post- EET, suggesting improvements in SkM oxidative capacity at the level of activation, translocation and post-translocation of fatty acids into the mitochondria. Conclusion: The capacity of SkM to oxidize fatty acids in obese AAW and CW was increased after 10 days of EET, suggesting that EET is an effective treatment for obesity in both racial groups.
General note	Presented by the faculty of the Department of Exercise and Sport Science.
General note	Advisor: Ronald N. Cortright
Dissertation note	M.A. East Carolina University 2004
Bibliography note	Included bibliographical references (leaves 62-69).
Genre/form	Academic theses.
Genre/form	Academic theses.
Genre/form	Thèses et écrits académiques.

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